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PDB: 85 results

1ZVW
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The Crystal Structure of TrpD (Rv2192c) from Mycobacterium tuberculosis in Complex with PRPP and Magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, BENZAMIDINE, ...
Authors:Lee, C.E, Lott, J.S, Baker, E.N, Arcus, V.L, Javid-Majd, F, Goodfellow, C, Hung, L.-W, TB Structural Genomics Consortium (TBSGC)
Deposit date:2005-06-02
Release date:2006-01-17
Last modified:2021-08-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate.
J.Mol.Biol., 355, 2006
1XVW
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Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin
Descriptor: Hypothetical protein Rv2238c/MT2298
Authors:Li, S, Peterson, N.A, Kim, M.Y, Kim, C.Y, Hung, L.W, Yu, M, Lekin, T, Segelke, B.W, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-10-28
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin
J.Mol.Biol., 346, 2005
1Y5H
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Crystal structure of truncated Se-Met Hypoxic Response Protein I (HRPI)
Descriptor: hypothetical protein RV2626C
Authors:Sharpe, M.L, Baker, E.N, Lott, J.S.
Deposit date:2004-12-02
Release date:2005-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis
J.Mol.Biol., 383, 2008
3OA5
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BU of 3oa5 by Molmil
The structure of chi1, a chitinase from Yersinia entomophaga
Descriptor: Chi1, GLYCEROL, NONAETHYLENE GLYCOL
Authors:Busby, J.N, Lott, J.S, Hurst, M.R.H.
Deposit date:2010-08-04
Release date:2011-08-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga
J.Mol.Biol., 415, 2012
1XKF
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Crystal structure of Hypoxic Response Protein I (HRPI) with two coordinated zinc ions
Descriptor: ZINC ION, hypothetical protein RV2626C
Authors:Sharpe, M.L, Baker, E.N, Lott, J.S.
Deposit date:2004-09-28
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis
J.Mol.Biol., 383, 2008
5BYT
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BU of 5byt by Molmil
PRPP complexed with a single Mg in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION
Authors:Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-11
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5CW8
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Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-4-cholesten-26-oyl-CoA
Descriptor: HTH-type transcriptional repressor KstR, S-{1-[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,7-dihydroxy-6,6-dimethyl-3-oxido-8,12 -dioxo-2,4-dioxa-9,13-diaza-3lambda~5~-phosphapentadecan-15-yl} (2S,6R)-6-[(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta [a]phenanthren-17-yl]-2-methylheptanethioate (non-preferred name), TRIETHYLENE GLYCOL
Authors:Ho, N.A.T, Dawes, S, Kendall, S, Casabon, I, Crowe, A.M, Baker, E.N, Eltis, L.D, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-27
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
5CXG
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Crystal structure of Mycobacterium tuberculosis KstR in complex with PEG
Descriptor: DI(HYDROXYETHYL)ETHER, HTH-type transcriptional repressor KstR, TRIETHYLENE GLYCOL
Authors:Ho, N.A.T, Dawes, S, Kendall, S, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-28
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1001 Å)
Cite:The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
5CXI
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BU of 5cxi by Molmil
Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (4-BNC-CoA)
Descriptor: 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA, HTH-type transcriptional repressor KstR
Authors:Ho, N.A.T, Dawes, S, Kendall, S, Casabon, I, Crowe, A.M, Baker, E.N, Eltis, L.D, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-29
Release date:2016-02-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
5CWA
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BU of 5cwa by Molmil
Structure of Anthranilate Synthase Component I (TrpE) from Mycobacterium tuberculosis with inhibitor bound
Descriptor: 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Anthranilate synthase component 1, GLYCEROL, ...
Authors:Johnston, J.M, Bashiri, G, Evans, G.L, Lott, J.S, Baker, E.N.
Deposit date:2015-07-28
Release date:2015-08-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
Acta Crystallogr.,Sect.D, 71, 2015
5C1R
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BU of 5c1r by Molmil
Stereoisomer of PRPP bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyl (AnPRT; trpD)
Descriptor: 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
Authors:Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-15
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP.
To Be Published
5C2L
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BU of 5c2l by Molmil
Magnesium soaked into the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Descriptor: Anthranilate phosphoribosyltransferase, IMIDAZOLE, MAGNESIUM ION
Authors:Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-16
Release date:2016-06-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP
To Be Published
5C7S
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BU of 5c7s by Molmil
PRPP complexed with two Mn2+ in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MANGANESE (II) ION
Authors:Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-24
Release date:2016-06-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP
To Be Published
4NKN
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BU of 4nkn by Molmil
The Crystal Structure of the N-terminal domain of COMMD9
Descriptor: COMM domain-containing protein 9
Authors:Hospenthal, M, Celligoi, D, Lott, J.S.
Deposit date:2013-11-12
Release date:2014-11-26
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural insights into the architecture and membrane interactions of the conserved COMMD proteins.
Elife, 7, 2018
4OWM
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BU of 4owm by Molmil
Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 3-fluoroanthranilate, PRPP and Magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-3-fluoranyl-benzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S.
Deposit date:2014-02-02
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWN
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BU of 4own by Molmil
Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 5-fluoroanthranilate, PRPP and Magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-5-fluorobenzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S.
Deposit date:2014-02-02
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWO
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BU of 4owo by Molmil
Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 6-fluoroanthranilate, PRPP and Magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-6-fluoranyl-benzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S.
Deposit date:2014-02-02
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWU
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BU of 4owu by Molmil
Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 5-methylanthranilate, PRPP and Magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-5-methyl-benzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S.
Deposit date:2014-02-03
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
3QSA
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BU of 3qsa by Molmil
Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor TAMU-A7)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel.
To be Published
3RV7
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Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-Group
Descriptor: 3-{[(1Z)-1-carboxy-3-methylbut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV6
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Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group
Descriptor: 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ...
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
4OE9
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BU of 4oe9 by Molmil
The crystal structure of the n-terminal domain of COMMD9
Descriptor: CITRIC ACID, COMM domain-containing protein 9, POTASSIUM ION
Authors:Hospenthal, M, Celligoi, D, Lott, J.S.
Deposit date:2014-01-12
Release date:2015-03-04
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights into the architecture and membrane interactions of the conserved COMMD proteins.
Elife, 7, 2018
3RV9
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Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Ethyl R-Group
Descriptor: 3-{[(1Z)-1-carboxybut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV8
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Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group
Descriptor: 3-{[(E)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
4NWZ
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BU of 4nwz by Molmil
Structure of bacterial type II NADH dehydrogenase from Caldalkalibacillus thermarum at 2.5A resolution
Descriptor: FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Nakatani, Y, Heikal, A, Lott, J.S, Sazanov, L.A, Baker, E.N, Cook, G.M.
Deposit date:2013-12-07
Release date:2014-02-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation.
Mol.Microbiol., 91, 2014

221051

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