PDB Search results for query - 日本蛋白质结构数据库

PDB: 889 results

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
Descriptor:	(5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione, Serine/threonine-protein kinase pim-1
Authors:	Liu, J.
Deposit date:	2012-01-02
Release date:	2012-03-21
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3VBY

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
Descriptor:	IMIDAZOLE, Serine/threonine-protein kinase pim-1, furan-2-yl(1H-indol-3-yl)methanone
Authors:	Liu, J.
Deposit date:	2012-01-02
Release date:	2012-03-21
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

6PW1

Cytochrome c Oxidase delta 16
Descriptor:	(2S,3R)-heptane-1,2,3-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, ...
Authors:	Liu, J, Ferguson-Miller, S.
Deposit date:	2019-07-21
Release date:	2019-11-27
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural changes at the surface of cytochrome c oxidase alter the proton-pumping stoichiometry. Biochim Biophys Acta Bioenerg, 1861, 2019

3VBW

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
Descriptor:	1,3-dioxo-2,3-dihydro-1H-indene-2-carbonitrile, Serine/threonine-protein kinase pim-1
Authors:	Liu, J.
Deposit date:	2012-01-02
Release date:	2012-03-21
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.48 Å)
Cite:	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

6PW0

Cytochrome C oxidase delta 6 mutant
Descriptor:	(2S,3R)-heptane-1,2,3-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, ...
Authors:	Liu, J, Ferguson-Miller, S.
Deposit date:	2019-07-21
Release date:	2019-11-27
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structural changes at the surface of cytochrome c oxidase alter the proton-pumping stoichiometry. Biochim Biophys Acta Bioenerg, 1861, 2019

8GW3

Crystal structure of human TAK1 kinase domain fused with TAB1
Descriptor:	Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Authors:	Liu, J, Sun, W, Gao, J.
Deposit date:	2022-09-16
Release date:	2023-09-20
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Crystal structure of human TAK1 kinase domain fused with TAB1 To Be Published

3VC4

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
Descriptor:	(5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, IMIDAZOLE, Serine/threonine-protein kinase pim-1
Authors:	Liu, J.
Deposit date:	2012-01-03
Release date:	2012-03-21
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.23 Å)
Cite:	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3VBX

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
Descriptor:	6-bromo-4-hydroxy-2H-chromen-2-one, Serine/threonine-protein kinase pim-1
Authors:	Liu, J.
Deposit date:	2012-01-02
Release date:	2012-03-21
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3VBT

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
Descriptor:	4-chloro-2-(1H-pyrazol-3-yl)phenol, Serine/threonine-protein kinase pim-1
Authors:	Liu, J.
Deposit date:	2012-01-02
Release date:	2012-03-21
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.23 Å)
Cite:	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012

3UIA

Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Glycoprotein 41
Authors:	Liu, J, Lu, M.
Deposit date:	2011-11-04
Release date:	2013-05-08
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein To be Published

6WXJ

CSF1R signaling is a regulator of pathogenesis in progressive MS
Descriptor:	4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine, Macrophage colony-stimulating factor 1 receptor
Authors:	Liu, J.
Deposit date:	2020-05-10
Release date:	2021-02-10
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.62 Å)
Cite:	CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell Death Dis, 11, 2020

7SO7

Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B
Descriptor:	FAB B1 LC, Fab B1 HC, Toxin B
Authors:	Liu, J.
Deposit date:	2021-10-29
Release date:	2022-05-11
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (3.59 Å)
Cite:	Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B. Curr Res Struct Biol, 4, 2022

7SO5

Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B
Descriptor:	Fab B2 HC, Fab B2 LC, Toxin B
Authors:	Liu, J.
Deposit date:	2021-10-29
Release date:	2022-05-11
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (1.797 Å)
Cite:	Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B. Curr Res Struct Biol, 4, 2022

8IB0

The amyloid structure of mouse RIPK1 RHIM-containing domain by solid-state NMR
Descriptor:	Receptor-interacting serine/threonine-protein kinase 1
Authors:	Liu, J, Xialian, W.
Deposit date:	2023-02-09
Release date:	2023-03-22
Last modified:	2024-08-28
Method:	SOLID-STATE NMR
Cite:	The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1/RIPK3 complex. Nat Commun, 15, 2024

4MJ5

Crystal Structure of HLA-A*1101 in complex with H1-22, an influenza A(H1N1) virus epitope
Descriptor:	Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ...
Authors:	Liu, J, Tan, S, Zhao, M, Qi, J, Gao, G.F.
Deposit date:	2013-09-03
Release date:	2014-10-08
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.401 Å)
Cite:	Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions. J.Infect.Dis., 214, 2016

4MJ6

Crystal Structure of HLA-A*1101 in complex with H7-22, an influenza A(H7N9) virus epitope
Descriptor:	Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ...
Authors:	Liu, J, Tan, S, Zhao, M, Qi, J, Gao, G.F.
Deposit date:	2013-09-03
Release date:	2014-10-08
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.57 Å)
Cite:	Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions. J.Infect.Dis., 214, 2016

5YJ8

Identification of a small molecule inhibitor for the Tudor domain of TDRD3
Descriptor:	5-(aminomethyl)-1,3-dimethyl-benzimidazol-2-one, SULFATE ION, Tudor domain-containing protein 3
Authors:	Liu, J, Ruan, K.
Deposit date:	2017-10-09
Release date:	2018-05-02
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.762 Å)
Cite:	Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit. FEBS J., 285, 2018

1JCC

Crystal Structure of a Novel Alanine-Zipper Trimer at 1.7 A Resolution, V13A,L16A,V20A,L23A,V27A,M30A,V34A mutations
Descriptor:	MAJOR OUTER MEMBRANE LIPOPROTEIN, ZINC ION
Authors:	Liu, J, Dai, J, Lu, M.
Deposit date:	2001-06-08
Release date:	2003-06-17
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Zinc-Mediated Helix Capping in A Triple-Helical Protein Biochemistry, 42, 2003

4K7A

Crystal structure of the androgen receptor ligand binding domain in complex with minoxidil
Descriptor:	5-ALPHA-DIHYDROTESTOSTERONE, 6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE, Androgen receptor
Authors:	Liu, J.S, Hsu, C.L, Wu, W.G.
Deposit date:	2013-04-16
Release date:	2014-04-16
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.44 Å)
Cite:	Crystal structure of the androgen receptor ligand binding domain in complex with minoxidil To be Published

6U2S

Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
Descriptor:	Bi-component leukocidin LukED subunit D, fos-choline-14
Authors:	Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
Deposit date:	2019-08-20
Release date:	2020-03-25
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020

6U33

Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
Descriptor:	Bi-component leukocidin LukED subunit D, NICKEL (II) ION
Authors:	Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
Deposit date:	2019-08-21
Release date:	2020-03-25
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020

6U3F

Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
Descriptor:	Panton-Valentine Leucocidin F, SULFATE ION, fos-choline-14
Authors:	Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
Deposit date:	2019-08-21
Release date:	2020-03-25
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.78 Å)
Cite:	Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020

6U3T

Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
Descriptor:	Alpha-hemolysin, SULFATE ION, fos-choline-14
Authors:	Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
Deposit date:	2019-08-22
Release date:	2020-03-25
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.79 Å)
Cite:	Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020

6U4P

Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
Descriptor:	Alpha-hemolysin, SULFATE ION, fos-choline-14
Authors:	Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
Deposit date:	2019-08-26
Release date:	2020-03-25
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.49 Å)
Cite:	Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020

5X56

Crystal structure of PSB27 from Arabidopsis thaliana
Descriptor:	Photosystem II repair protein PSB27-H1, chloroplastic
Authors:	Liu, J, Cheng, X.
Deposit date:	2017-02-15
Release date:	2017-12-27
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Crystal structure of Psb27 from Arabidopsis thaliana determined at a resolution of 1.85 angstrom. Photosyn. Res., 136, 2018

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Total results:	889
Displayed results:	25
Sorted by:	Hit score (from highest)
Deposition authors:	"Liu, J.S"