8JHF
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![BU of 8jhf by Molmil](/molmil-images/mine/8jhf) | Native SUV420H1 bound to 167-bp nucleosome | Descriptor: | DNA (160-MER), Histone H2A.Z, Histone H2B type 1-K, ... | Authors: | Lin, F, Li, W. | Deposit date: | 2023-05-23 | Release date: | 2023-11-15 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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8JHG
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![BU of 8jhg by Molmil](/molmil-images/mine/8jhg) | Native SUV420H1 bound to 167-bp nucleosome | Descriptor: | DNA (160-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | Authors: | Lin, F, Li, W. | Deposit date: | 2023-05-23 | Release date: | 2023-11-22 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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7ZBQ
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![BU of 7zbq by Molmil](/molmil-images/mine/7zbq) | Structure of the ADP-ribosyltransferase TccC3HVR from Photorhabdus Luminescens | Descriptor: | TccC3 | Authors: | Lindemann, F, Belyy, A, Friedrich, D, Schmieder, P, Bardiaux, B, Roderer, D, Funk, J, Protze, J, Bieling, P, Oschkinat, H, Raunser, S. | Deposit date: | 2022-03-24 | Release date: | 2022-06-29 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin. Nat Commun, 13, 2022
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2QHX
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![BU of 2qhx by Molmil](/molmil-images/mine/2qhx) | Structure of Pteridine Reductase from Leishmania major complexed with a ligand | Descriptor: | IODIDE ION, METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Gibellini, F, Mcluskey, K, Tulloch, L, Hunter, W.N. | Deposit date: | 2007-07-03 | Release date: | 2007-12-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proc.Natl.Acad.Sci.USA, 105, 2008
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1M11
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![BU of 1m11 by Molmil](/molmil-images/mine/1m11) | structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy | Descriptor: | COAT PROTEIN VP1, COAT PROTEIN VP2, COAT PROTEIN VP3, ... | Authors: | He, Y, Lin, F, Chipman, P.R, Bator, C.M, Baker, T.S, Shoham, M, Kuhn, R.J, Medof, M.E, Rossmann, M.G. | Deposit date: | 2002-06-17 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (16 Å) | Cite: | Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex. Proc.Natl.Acad.Sci.USA, 99, 2002
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6LKA
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![BU of 6lka by Molmil](/molmil-images/mine/6lka) | Crystal Structure of EV71-3C protease with a Novel Macrocyclic Compounds | Descriptor: | 3C proteinase, ~{N}-[(2~{S})-1-[[(2~{S},3~{S},6~{S},7~{Z},12~{E})-4,9-bis(oxidanylidene)-6-[[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]methyl]-2-phenyl-1,10-dioxa-5-azacyclopentadeca-7,12-dien-3-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Li, P, Wu, S.Q, Xiao, T.Y.C, Li, Y.L, Su, Z.M, Hao, F, Hu, G.P, Hu, J, Lin, F.S, Chen, X.S, Gu, Z.X, He, H.Y, Li, J, Chen, S.H. | Deposit date: | 2019-12-18 | Release date: | 2020-06-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.033 Å) | Cite: | Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent. Bioorg.Med.Chem., 28, 2020
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3IYP
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![BU of 3iyp by Molmil](/molmil-images/mine/3iyp) | The Interaction of Decay-accelerating Factor with Echovirus 7 | Descriptor: | Capsid protein, Complement decay-accelerating factor, LAURIC ACID, ... | Authors: | Plevka, P, Hafenstein, S, Zhang, Y, Harris, K.G, Cifuente, J.O, Bowman, V.D, Chipman, P.R, Lin, F, Medof, D.E, Bator, C.M, Rossmann, M.G. | Deposit date: | 2010-04-07 | Release date: | 2010-11-24 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Interaction of decay-accelerating factor with echovirus 7. J.Virol., 84, 2010
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4UV2
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![BU of 4uv2 by Molmil](/molmil-images/mine/4uv2) | Structure of the curli transport lipoprotein CsgG in a non-lipidated, pre-pore conformation | Descriptor: | CURLI PRODUCTION TRANSPORT COMPONENT CSGG | Authors: | Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H. | Deposit date: | 2014-08-04 | Release date: | 2014-09-24 | Last modified: | 2014-12-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg. Nature, 516, 2014
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1YZ3
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![BU of 1yz3 by Molmil](/molmil-images/mine/1yz3) | Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139 | Descriptor: | 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Wu, Q, Gee, C.L, Lin, F, Martin, J.L, Grunewald, G.L, McLeish, M.J. | Deposit date: | 2005-02-27 | Release date: | 2006-02-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase J.Med.Chem., 48, 2005
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6F4U
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![BU of 6f4u by Molmil](/molmil-images/mine/6f4u) | |
8GY0
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![BU of 8gy0 by Molmil](/molmil-images/mine/8gy0) | Agrocybe pediades linalool sunthase (Ap.LS) | Descriptor: | Terpene synthase | Authors: | Rehka, T, Sharma, D, Lin, F, Lim, C, Choong, Y.K, Chacko, J, Zhang, C. | Deposit date: | 2022-09-21 | Release date: | 2023-04-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.988 Å) | Cite: | Structural Understanding of Fungal Terpene Synthases for the Formation of Linear or Cyclic Terpene Products. Acs Catalysis, 13, 2023
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1MJ1
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![BU of 1mj1 by Molmil](/molmil-images/mine/1mj1) | FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME | Descriptor: | Elongation Factor Tu, L11 ribosomal protein, Phe-tRNA, ... | Authors: | Stark, H, Rodnina, M.V, Wieden, H.-J, Zemlin, F, Wintermeyer, W, Vanheel, M. | Deposit date: | 2002-08-26 | Release date: | 2002-11-01 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (13 Å) | Cite: | Ribosome Interactions of Aminoacyl-tRNA and Elongation Factor TU in the
Codon Recognition Complex Nat.Struct.Biol., 9, 2002
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2QZF
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![BU of 2qzf by Molmil](/molmil-images/mine/2qzf) | SCR1 of DAF from 1ojv fitted into cryoEM density | Descriptor: | Complement decay-accelerating factor | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | Deposit date: | 2007-08-16 | Release date: | 2007-10-30 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (14 Å) | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3. J.Virol., 81, 2007
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2QZH
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![BU of 2qzh by Molmil](/molmil-images/mine/2qzh) | SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF | Descriptor: | Complement decay-accelerating factor | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | Deposit date: | 2007-08-16 | Release date: | 2007-10-30 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (14 Å) | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3. J.Virol., 81, 2007
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2AIZ
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![BU of 2aiz by Molmil](/molmil-images/mine/2aiz) | Solution structure of peptidoglycan associated lipoprotein from Haemophilus influenza bound to UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine | Descriptor: | L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine, N-acetyl-beta-muramic acid, Outer membrane protein P6 (Fragment), ... | Authors: | Parsons, L.M, Lin, F, Orban, J, Structure 2 Function Project (S2F) | Deposit date: | 2005-08-01 | Release date: | 2006-03-14 | Last modified: | 2023-02-15 | Method: | SOLUTION NMR | Cite: | Peptidoglycan recognition by pal, an outer membrane lipoprotein. Biochemistry, 45, 2006
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2CH0
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![BU of 2ch0 by Molmil](/molmil-images/mine/2ch0) | Solution structure of the human MAN1 C-terminal domain (residues 655- 775) | Descriptor: | INNER NUCLEAR MEMBRANE PROTEIN MAN1 | Authors: | Caputo, S, Couprie, J, Duband-Goulet, I, Lin, F, Braud, S, Gondry, M, Worman, H.J, Gilquin, B, Zinn-Justin, S. | Deposit date: | 2006-03-10 | Release date: | 2006-05-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain. J. Biol. Chem., 281, 2006
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1NWV
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![BU of 1nwv by Molmil](/molmil-images/mine/1nwv) | SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR | Descriptor: | Complement decay-accelerating factor | Authors: | Uhrinova, S, Lin, F, Ball, G, Bromek, K, Uhrin, D, Medof, M.E, Barlow, P.N. | Deposit date: | 2003-02-07 | Release date: | 2003-04-22 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of a functionally active fragment of decay-accelerating factor Proc.Natl.Acad.Sci.USA, 100, 2003
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6WY6
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![BU of 6wy6 by Molmil](/molmil-images/mine/6wy6) | Crystal structure of S. cerevisiae Atg8 in complex with Ede1 (1220-1247) | Descriptor: | Autophagy-related protein 8, EH domain-containing and endocytosis protein 1 | Authors: | Zheng, Y, Wilfling, F, Baumeister, W, Schulman, B.A. | Deposit date: | 2020-05-12 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.773 Å) | Cite: | A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Mol.Cell, 80, 2020
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2QZD
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![BU of 2qzd by Molmil](/molmil-images/mine/2qzd) | Fitted structure of SCR4 of DAF into cryoEM density | Descriptor: | Complement decay-accelerating factor | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | Deposit date: | 2007-08-16 | Release date: | 2007-10-30 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (14 Å) | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3. J.Virol., 81, 2007
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4UV3
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![BU of 4uv3 by Molmil](/molmil-images/mine/4uv3) | Structure of the curli transport lipoprotein CsgG in its membrane- bound conformation | Descriptor: | CURLI PRODUCTION ASSEMBLY/TRANSPORT COMPONENT CSGG | Authors: | Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H. | Deposit date: | 2014-08-04 | Release date: | 2014-09-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.59 Å) | Cite: | Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg. Nature, 516, 2014
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6Z0F
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![BU of 6z0f by Molmil](/molmil-images/mine/6z0f) | Crystal structure of the membrane pseudokinase YukC/EssB from Bacillus subtilis T7SS | Descriptor: | ESX secretion system protein YukC | Authors: | Tassinari, M, Bellinzoni, M, Alzari, P.M, Fronzes, R, Gubellini, F. | Deposit date: | 2020-05-08 | Release date: | 2021-05-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.553 Å) | Cite: | The Antibacterial Type VII Secretion System of Bacillus subtilis: Structure and Interactions of the Pseudokinase YukC/EssB. Mbio, 13, 2022
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6S4A
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![BU of 6s4a by Molmil](/molmil-images/mine/6s4a) | Structure of human MTHFD2 in complex with TH9028 | Descriptor: | (2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | Authors: | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | Deposit date: | 2019-06-27 | Release date: | 2021-07-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer, 3, 2022
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6S4F
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![BU of 6s4f by Molmil](/molmil-images/mine/6s4f) | Structure of human MTHFD2 in complex with TH9619 | Descriptor: | (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid, ADENOSINE-5'-DIPHOSPHATE, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | Authors: | Scaletti, E.R, Gustafsson, R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | Deposit date: | 2019-06-27 | Release date: | 2021-07-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer, 3, 2022
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6S4E
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![BU of 6s4e by Molmil](/molmil-images/mine/6s4e) | Structure of human MTHFD2 in complex with TH7299 | Descriptor: | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | Authors: | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | Deposit date: | 2019-06-27 | Release date: | 2021-07-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer, 3, 2022
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8AS8
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![BU of 8as8 by Molmil](/molmil-images/mine/8as8) | E. coli Wadjet JetABC monomer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | Authors: | Roisne-Hamelin, F, Beckert, B, Li, Y, Myasnikov, A, Gruber, S. | Deposit date: | 2022-08-18 | Release date: | 2022-12-14 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage. Mol.Cell, 82, 2022
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