8AS8
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![BU of 8as8 by Molmil](/molmil-images/mine/8as8) | E. coli Wadjet JetABC monomer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | Authors: | Roisne-Hamelin, F, Beckert, B, Li, Y, Myasnikov, A, Gruber, S. | Deposit date: | 2022-08-18 | Release date: | 2022-12-14 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage. Mol.Cell, 82, 2022
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8BFN
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![BU of 8bfn by Molmil](/molmil-images/mine/8bfn) | E. coli Wadjet JetABC dimer of dimers | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | Authors: | Roisne-Hamelin, F, Beckert, B, Myasnikov, A, Li, Y, Gruber, S. | Deposit date: | 2022-10-26 | Release date: | 2022-12-14 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage. Mol.Cell, 82, 2022
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8Q72
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![BU of 8q72 by Molmil](/molmil-images/mine/8q72) | E. coli plasmid-borne JetABCD(E248A) core in a cleavage-competent state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Circular plasmid DNA (1840-MER), JetA, ... | Authors: | Roisne-Hamelin, F, Li, Y, Gruber, S. | Deposit date: | 2023-08-15 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.17 Å) | Cite: | Structural basis for plasmid restriction by SMC JET nuclease. Mol.Cell, 84, 2024
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6FOE
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![BU of 6foe by Molmil](/molmil-images/mine/6foe) | BaxB01 Fab fragment | Descriptor: | Fab BaxB01 heavy chain, Fab BaxB01 light chain | Authors: | Hollerweger, J, Schinagl, A, Kerschbaumer, R.J, Scheiflinger, F, Thiele, M, Goettig, P, Brandstetter, H. | Deposit date: | 2018-02-07 | Release date: | 2018-02-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch. Biochemistry, 57, 2018
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6HVC
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![BU of 6hvc by Molmil](/molmil-images/mine/6hvc) | NMR structure of Urotensin Peptide Asp-c[Cys-Phe-Trp-(N-Me)Lys-Tyr-Cys]-Val in SDS solution | Descriptor: | Urotensin-2 | Authors: | Brancaccio, D, Carotenuto, A, Merlino, F, Billard, E, Yousif, A.M, Di Maro, S, Abate, L, Bellavita, R, D'Emmanuele di Villa Bianca, R, Santicioli, P, Marinelli, L, Novellino, E, Hebert, T.E, Lubell, W.D, Chatenet, D, Grieco, P. | Deposit date: | 2018-10-10 | Release date: | 2019-01-16 | Last modified: | 2019-04-24 | Method: | SOLUTION NMR | Cite: | Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. J.Med.Chem., 62, 2019
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6HVB
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![BU of 6hvb by Molmil](/molmil-images/mine/6hvb) | NMR structure of Urotensin Peptide Asp-c[Cys-Phe-(N-Me)Trp-Lys-Tyr-Cys]-Val in SDS solution | Descriptor: | Urotensin-2 | Authors: | Brancaccio, D, Carotenuto, A, Merlino, F, Billard, E, Yousif, A.M, Di Maro, S, Abate, L, Bellavita, R, D'Emmanuele di Villa Bianca, R, Santicioli, P, Marinelli, L, Novellino, E, Hebert, T.E, Lubell, W.D, Chatenet, D, Grieco, P. | Deposit date: | 2018-10-10 | Release date: | 2019-01-16 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. J.Med.Chem., 62, 2019
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6WY6
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![BU of 6wy6 by Molmil](/molmil-images/mine/6wy6) | Crystal structure of S. cerevisiae Atg8 in complex with Ede1 (1220-1247) | Descriptor: | Autophagy-related protein 8, EH domain-containing and endocytosis protein 1 | Authors: | Zheng, Y, Wilfling, F, Baumeister, W, Schulman, B.A. | Deposit date: | 2020-05-12 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.773 Å) | Cite: | A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Mol.Cell, 80, 2020
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7UCX
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![BU of 7ucx by Molmil](/molmil-images/mine/7ucx) | LRP8 11H1 Fab complexed to a cyclized CR1 peptide | Descriptor: | 11H1 Fab Heavy chain, 11H1 Fab Light chain, Cyclized CR1 peptide, ... | Authors: | Argiriadi, M.A, Deng, K, Egan, D, Gao, L, Gizatullin, F, Harlan, J, Karaoglu, D, Qiu, W, Goodearl, A. | Deposit date: | 2022-03-17 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The use of cyclic peptide antigens to generate LRP8 specific antibodies Front Drug Discov (Lausanne), 2, 2023
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1UG3
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![BU of 1ug3 by Molmil](/molmil-images/mine/1ug3) | C-terminal portion of human eIF4GI | Descriptor: | eukaryotic protein synthesis initiation factor 4G | Authors: | Bellsolell, L, Cho-Park, P.F, Poulin, F, Sonenberg, N, Burley, S.K. | Deposit date: | 2003-06-11 | Release date: | 2005-03-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1 Structure, 14, 2006
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5TGL
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![BU of 5tgl by Molmil](/molmil-images/mine/5tgl) | A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX | Descriptor: | LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER | Authors: | Brzozowski, A.M, Derewenda, U, Derewenda, Z.S, Dodson, G.G, Lawson, D, Turkenburg, J.P, Bjorkling, F, Huge-Jensen, B, Patkar, S.R, Thim, L. | Deposit date: | 1991-10-30 | Release date: | 1994-01-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex. Nature, 351, 1991
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2N7O
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![BU of 2n7o by Molmil](/molmil-images/mine/2n7o) | NMR Structure of Peptide PG-990 in DPC micelles | Descriptor: | Peptide PG-990 | Authors: | Carotenuto, A, Merlino, F, Chai, M, Brancaccio, D, Yousif, A, Novellino, E, Hruby, V, Grieco, P. | Deposit date: | 2015-09-16 | Release date: | 2015-12-16 | Last modified: | 2017-10-11 | Method: | SOLUTION NMR | Cite: | Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J.Med.Chem., 58, 2015
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2N7T
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![BU of 2n7t by Molmil](/molmil-images/mine/2n7t) | NMR structure of Peptide PG-992 in DPC micelles | Descriptor: | Peptide PG-992 | Authors: | Carotenuto, A, Merlino, F, Chai, M, Brancaccio, D, Yousif, A, Novellino, E, Hruby, V, Grieco, P. | Deposit date: | 2015-09-17 | Release date: | 2015-12-16 | Last modified: | 2017-10-11 | Method: | SOLUTION NMR | Cite: | Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J.Med.Chem., 58, 2015
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2N7N
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![BU of 2n7n by Molmil](/molmil-images/mine/2n7n) | NMR structure of Peptide PG-989 in DPC micelles | Descriptor: | Peptide PG-989 | Authors: | Carotenuto, A, Merlino, F, Chai, M, Brancaccio, D, Yousif, A, Novellino, E, Hruby, V, Grieco, P. | Deposit date: | 2015-09-16 | Release date: | 2015-12-16 | Last modified: | 2017-10-11 | Method: | SOLUTION NMR | Cite: | Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J.Med.Chem., 58, 2015
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3H4V
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![BU of 3h4v by Molmil](/molmil-images/mine/3h4v) | Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1 | Descriptor: | METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1 | Authors: | Mcluskey, K, Gibellini, F, Hunter, W.N. | Deposit date: | 2009-04-21 | Release date: | 2009-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development Proc.Natl.Acad.Sci.USA, 105, 2008
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1QIB
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![BU of 1qib by Molmil](/molmil-images/mine/1qib) | CRYSTAL STRUCTURE OF GELATINASE A CATALYTIC DOMAIN | Descriptor: | 72 kDa type IV collagenase, CALCIUM ION, ZINC ION | Authors: | Dhanaraj, V, Williams, M.G, Ye, Q.-Z, Molina, F, Johnson, L.L, Ortwine, D.F, Pavlovsky, A, Rubin, J.R, Skeean, R.W, White, A.D, Humblet, C, Hupe, D.J, Blundell, T.L. | Deposit date: | 1999-06-11 | Release date: | 1999-11-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-ray structure of gelatinase A catalytic domain complexed with a hydroxamate inhibitor Croatica Chemica Acta, 72, 1999
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1QFC
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![BU of 1qfc by Molmil](/molmil-images/mine/1qfc) | STRUCTURE OF RAT PURPLE ACID PHOSPHATASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PHOSPHATE ION, ... | Authors: | Uppenberg, J, Lindqvist, F, Svensson, C, Ek-Rylander, B, Andersson, G. | Deposit date: | 1999-04-08 | Release date: | 2000-04-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a mammalian purple acid phosphatase. J.Mol.Biol., 290, 1999
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5V4U
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![BU of 5v4u by Molmil](/molmil-images/mine/5v4u) | |
3RPL
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![BU of 3rpl by Molmil](/molmil-images/mine/3rpl) | D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase of Synechocystis sp. PCC 6803 in complex with FRUCTOSE-1,6-BISPHOSPHATE | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | Authors: | Hu, X, Hui, D, Lingling, F, Jian, W. | Deposit date: | 2011-04-26 | Release date: | 2012-05-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | New insights into the structural and interactional basis for a promising route towards fructose-1,6-/sedoheptulose-1,7-bisphosphatases controlling To be Published
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3ROJ
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![BU of 3roj by Molmil](/molmil-images/mine/3roj) | D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase of Synechocystis sp. PCC 6803 | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase, ... | Authors: | Hu, X, Hui, D, Lingling, F, Jian, W. | Deposit date: | 2011-04-26 | Release date: | 2012-05-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | New insights into the structural and interactional basis for a promising route towards fructose-1,6-/sedoheptulose-1,7-bisphosphatases controlling To be Published
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1MJ1
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![BU of 1mj1 by Molmil](/molmil-images/mine/1mj1) | FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME | Descriptor: | Elongation Factor Tu, L11 ribosomal protein, Phe-tRNA, ... | Authors: | Stark, H, Rodnina, M.V, Wieden, H.-J, Zemlin, F, Wintermeyer, W, Vanheel, M. | Deposit date: | 2002-08-26 | Release date: | 2002-11-01 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (13 Å) | Cite: | Ribosome Interactions of Aminoacyl-tRNA and Elongation Factor TU in the
Codon Recognition Complex Nat.Struct.Biol., 9, 2002
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2VVU
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![BU of 2vvu by Molmil](/molmil-images/mine/2vvu) | Aminopyrrolidine Factor Xa inhibitor | Descriptor: | 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | Authors: | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | Deposit date: | 2008-06-11 | Release date: | 2009-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit. Eur.J.Med.Chem., 44, 2009
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2VWL
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![BU of 2vwl by Molmil](/molmil-images/mine/2vwl) | Aminopyrrolidine Factor Xa inhibitor | Descriptor: | 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3R,5S)-1-{[2-FLUORO-4-(2-OXO-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-5-HYDROXYMETHYL-PYRROLIDIN-3-YL)-AMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | Authors: | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | Deposit date: | 2008-06-26 | Release date: | 2009-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit. Eur.J.Med.Chem., 44, 2009
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2VVV
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![BU of 2vvv by Molmil](/molmil-images/mine/2vvv) | Aminopyrrolidine-related triazole Factor Xa inhibitor | Descriptor: | 5-chloro-N-[1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-1H-1,2,4-triazol-3-yl]thiophene-2-carboxamide, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | Authors: | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | Deposit date: | 2008-06-12 | Release date: | 2009-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit. Eur.J.Med.Chem., 44, 2009
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2C7V
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![BU of 2c7v by Molmil](/molmil-images/mine/2c7v) | Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate | Descriptor: | ACETATE ION, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Dawson, A, Gibellini, F, Sienkiewicz, N, Fyfe, P.K, McLuskey, K, Fairlamb, A.H, Hunter, W.N. | Deposit date: | 2005-11-29 | Release date: | 2006-09-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate Mol.Microbiol., 61, 2006
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2VWO
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![BU of 2vwo by Molmil](/molmil-images/mine/2vwo) | Aminopyrrolidine Factor Xa inhibitor | Descriptor: | 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | Authors: | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | Deposit date: | 2008-06-26 | Release date: | 2009-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit. Eur.J.Med.Chem., 44, 2009
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