2N7T

NMR structure of Peptide PG-992 in DPC micelles

Summary for 2N7T

Entry DOI	10.2210/pdb2n7t/pdb
NMR Information	BMRB: 25820
Descriptor	Peptide PG-992 (1 entity in total)
Functional Keywords	de novo protein
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	1223.45
Authors	Carotenuto, A.,Merlino, F.,Chai, M.,Brancaccio, D.,Yousif, A.,Novellino, E.,Hruby, V.,Grieco, P. (deposition date: 2015-09-17, release date: 2015-12-16, Last modification date: 2024-11-27)
Primary citation	Carotenuto, A.,Merlino, F.,Cai, M.,Brancaccio, D.,Yousif, A.M.,Novellino, E.,Hruby, V.J.,Grieco, P. Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J.Med.Chem., 58:9773-9778, 2015 Cited by PubMed Abstract: The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor. PubMed: 26599352 DOI: 10.1021/acs.jmedchem.5b01285 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation