2C7V
Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate
Summary for 2C7V
Entry DOI | 10.2210/pdb2c7v/pdb |
Descriptor | PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (6 entities in total) |
Functional Keywords | pteridine reductase, trypanosomatids, drug resistance, short-chain dehydrogenase/reductase, methotrexate resistance, oxidoreductase |
Biological source | TRYPANOSOMA BRUCEI BRUCEI |
Total number of polymer chains | 4 |
Total formula weight | 119980.47 |
Authors | Dawson, A.,Gibellini, F.,Sienkiewicz, N.,Fyfe, P.K.,McLuskey, K.,Fairlamb, A.H.,Hunter, W.N. (deposition date: 2005-11-29, release date: 2006-09-19, Last modification date: 2023-12-13) |
Primary citation | Dawson, A.,Gibellini, F.,Sienkiewicz, N.,Tulloch, L.B.,Fyfe, P.K.,Mcluskey, K.,Fairlamb, A.H.,Hunter, W.N. Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate Mol.Microbiol., 61:1457-, 2006 Cited by PubMed: 16968221DOI: 10.1111/J.1365-2958.2006.05332.X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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