2C7V
Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | PTERIDINE REDUCTASE | polymer | 268 | 28738.4 | 4 | UniProt (O76290) Pfam (PF13561) | TRYPANOSOMA BRUCEI BRUCEI | |
| 2 | E, I, M, O (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, J, N, P (A, B, C, D) | METHOTREXATE | non-polymer | 454.4 | 4 | Chemie (MTX) | |||
| 4 | G, K (A, B) | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
| 5 | H, L (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 799 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 114953.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5026.9 | |
| All* | Total formula weight | 119980.5 |
