8W4N
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![BU of 8w4n by Molmil](/molmil-images/mine/8w4n) | Crystal structure of EndoSz mutant D234M, in space group P21, in complex with oligosaccharide G2S1 | Descriptor: | CALCIUM ION, Glycoside hydrolase, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | Deposit date: | 2023-08-24 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au, 4, 2024
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8W4I
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![BU of 8w4i by Molmil](/molmil-images/mine/8w4i) | Crystal structure of EndoSz mutant D234M in space group P21 | Descriptor: | CALCIUM ION, glycoside hydrolase | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | Deposit date: | 2023-08-24 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au, 4, 2024
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8X8G
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![BU of 8x8g by Molmil](/molmil-images/mine/8x8g) | Crystal structure of EndoSz mutant D234M, from Streptococcus equi subsp. Zooepidemicus Sz105, in complex with oligosaccharide G2S2-oxazoline | Descriptor: | 2-METHYL-4,5-DIHYDRO-(1,2-DIDEOXY-ALPHA-D-GLUCOPYRANOSO)[2,1-D]-1,3-OXAZOLE, CALCIUM ION, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, ... | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | Deposit date: | 2023-11-27 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au, 4, 2024
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5H7W
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![BU of 5h7w by Molmil](/molmil-images/mine/5h7w) | |
6LD0
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![BU of 6ld0 by Molmil](/molmil-images/mine/6ld0) | Structure of Bifidobacterium dentium beta-glucuronidase complexed with C6-hexyl uronic isofagomine | Descriptor: | (2~{S},3~{S},4~{R},5~{R})-2-hexyl-4,5-bis(oxidanyl)piperidine-3-carboxylic acid, LacZ1 Beta-galactosidase | Authors: | Lin, H.-Y, Hsieh, T.-J, Lin, C.-H. | Deposit date: | 2019-11-20 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4, 2021
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6LDB
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![BU of 6ldb by Molmil](/molmil-images/mine/6ldb) | Structure of Bifidobacterium dentium beta-glucuronidase complexed with uronic isofagomine | Descriptor: | (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid, LacZ1 Beta-galactosidase | Authors: | Lin, H.-Y, Hsieh, T.-J, Lin, C.-H. | Deposit date: | 2019-11-20 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4, 2021
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6LD6
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![BU of 6ld6 by Molmil](/molmil-images/mine/6ld6) | |
6DA1
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![BU of 6da1 by Molmil](/molmil-images/mine/6da1) | ETS1 in complex with synthetic SRR mimic | Descriptor: | Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide | Authors: | Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. | Deposit date: | 2018-05-01 | Release date: | 2019-01-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.000127 Å) | Cite: | The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. J. Mol. Biol., 431, 2019
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6DAT
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![BU of 6dat by Molmil](/molmil-images/mine/6dat) | ETS1 in complex with synthetic SRR mimic | Descriptor: | Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide | Authors: | Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. | Deposit date: | 2018-05-02 | Release date: | 2019-01-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.35002637 Å) | Cite: | The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. J. Mol. Biol., 431, 2019
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8Y2U
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![BU of 8y2u by Molmil](/molmil-images/mine/8y2u) | Crystal structure of 3C protease from coxsackievirus B4 | Descriptor: | Protease 3C | Authors: | Jiang, H.H, Lin, C, Zhang, J, Li, J. | Deposit date: | 2024-01-27 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Crystal structures of the 3C proteases from Coxsackievirus B3 and B4. Acta Crystallogr.,Sect.F, 80, 2024
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7CBA
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![BU of 7cba by Molmil](/molmil-images/mine/7cba) | |
7C2Q
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![BU of 7c2q by Molmil](/molmil-images/mine/7c2q) | The crystal structure of COVID-19 main protease in the apo state | Descriptor: | 3C-like proteinase | Authors: | Zhou, X.L, Zhong, F.L, Lin, C, Hu, X.H, Zhou, H, Wang, Q.S, Li, j, Zhang, J. | Deposit date: | 2020-05-08 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structure of SARS-CoV-2 main protease in the apo state. Sci China Life Sci, 64, 2021
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7CA8
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![BU of 7ca8 by Molmil](/molmil-images/mine/7ca8) | The crystal structure of COVID-19 main protease in complex with an inhibitor Shikonin | Descriptor: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | Authors: | Zhou, X.L, Zhong, F.L, Lin, C, Li, J, Zhang, J. | Deposit date: | 2020-06-08 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. Sci Bull (Beijing), 66, 2021
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4Y24
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![BU of 4y24 by Molmil](/molmil-images/mine/4y24) | Complex of human Galectin-1 and TD-139 | Descriptor: | 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, Galectin-1 | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors. Sci Rep, 6, 2016
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7C1I
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![BU of 7c1i by Molmil](/molmil-images/mine/7c1i) | Crystal structure of histidine-containing phosphotransfer protein B (HptB) from Pseudomonas aeruginosa PAO1 | Descriptor: | Histidine kinase | Authors: | Chen, S.K, Guan, H.H, Wu, P.H, Lin, L.T, Wu, M.C, Chang, H.Y, Chen, N.C, Lin, C.C, Chuankhayan, P, Huang, Y.C, Lin, P.J, Chen, C.J. | Deposit date: | 2020-05-04 | Release date: | 2020-11-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa Iucrj, 7, 2020
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7C1J
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![BU of 7c1j by Molmil](/molmil-images/mine/7c1j) | Crystal structure of the receiver domain of sensor histidine kinase PA1611 (PA1611REC) from Pseudomonas aeruginosa PAO1 with magnesium ion coordinated in the active site cleft | Descriptor: | Histidine kinase, MAGNESIUM ION | Authors: | Chen, S.K, Guan, H.H, Wu, P.H, Lin, L.T, Wu, M.C, Chang, H.Y, Chen, N.C, Lin, C.C, Chuankhayan, P, Huang, Y.C, Lin, P.J, Chen, C.J. | Deposit date: | 2020-05-04 | Release date: | 2020-11-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa Iucrj, 7, 2020
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7CFW
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![BU of 7cfw by Molmil](/molmil-images/mine/7cfw) | Crystal structure of the receiver domain of sensor histidine kinase PA1611 (PA1611REC) from Pseudomonas aeruginosa PAO1 with calcium ion coordinated in the active site cleft | Descriptor: | CALCIUM ION, Histidine kinase | Authors: | Chen, S.K, Guan, H.H, Wu, P.H, Lin, L.T, Wu, M.C, Chang, H.Y, Chen, N.C, Lin, C.C, Chuankhayan, P, Huang, Y.C, Lin, P.J, Chen, C.J. | Deposit date: | 2020-06-29 | Release date: | 2020-11-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa Iucrj, 7, 2020
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4Y20
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![BU of 4y20 by Molmil](/molmil-images/mine/4y20) | Complex of human Galectin-1 and NeuAcalpha2-3Galbeta1-4Glc | Descriptor: | Galectin-1, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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4Y1X
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![BU of 4y1x by Molmil](/molmil-images/mine/4y1x) | Complex of human Galectin-1 and Galbeta1-4(6OSO3)GlcNAc | Descriptor: | Galectin-1, beta-D-galactopyranose-(1-4)-methyl 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranoside | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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4Y1V
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![BU of 4y1v by Molmil](/molmil-images/mine/4y1v) | Complex of human Galectin-1 and Galbeta1-3GlcNAc | Descriptor: | Galectin-1, beta-D-galactopyranose-(1-3)-methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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4Y1U
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![BU of 4y1u by Molmil](/molmil-images/mine/4y1u) | Complex of human Galectin-1 and Galbeta1-4GlcNAc | Descriptor: | Galectin-1, beta-D-galactopyranose-(1-4)-methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.762 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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4Y26
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![BU of 4y26 by Molmil](/molmil-images/mine/4y26) | Complex of human Galectin-7 and Galbeta1-3(6OSO3)GlcNAc | Descriptor: | Galectin-7, beta-D-galactopyranose-(1-3)-methyl 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranoside | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.611 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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4Y22
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![BU of 4y22 by Molmil](/molmil-images/mine/4y22) | Complex of human Galectin-1 and (3OSO3)Galbeta1-3GlcNAc | Descriptor: | 3-O-sulfo-beta-D-galactopyranose-(1-3)-methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, Galectin-1 | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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4Y1Z
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![BU of 4y1z by Molmil](/molmil-images/mine/4y1z) | Complex of human Galectin-1 and Galbeta1-4(6CO2)GlcNAc | Descriptor: | Galectin-1, beta-D-galactopyranose-(1-4)-methyl 2-acetamido-2-deoxy-beta-D-glucopyranosiduronic acid | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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4Y1Y
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![BU of 4y1y by Molmil](/molmil-images/mine/4y1y) | Complex of human Galectin-1 and (6OSO3)Galbeta1-3GlcNAc | Descriptor: | Galectin-1, beta-D-galactopyranose-(1-3)-methyl 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranoside | Authors: | Lin, H.Y, Hsieh, T.J, Lin, C.H. | Deposit date: | 2015-02-09 | Release date: | 2016-04-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To Be Published
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