6POR
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![BU of 6por by Molmil](/molmil-images/mine/6por) | Antimicrobial lasso peptide ubonodin | Descriptor: | Ubonodin | Authors: | Link, A.J, Cheung-Lee, W.L. | Deposit date: | 2019-07-05 | Release date: | 2019-12-04 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex. Chembiochem, 21, 2020
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5KTC
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![BU of 5ktc by Molmil](/molmil-images/mine/5ktc) | FdhC with bound products: Coenzyme A and 3-[(R)-3-hydroxybutanoylamino]-3,6-dideoxy-d-galactose | Descriptor: | 1,2-ETHANEDIOL, COENZYME A, FdhC, ... | Authors: | Salinger, A.J, Thoden, J.B, Holden, H.M. | Deposit date: | 2016-07-11 | Release date: | 2016-07-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily. Biochemistry, 55, 2016
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5KTA
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![BU of 5kta by Molmil](/molmil-images/mine/5kta) | Apo FdhC- a nucleotide-linked sugar GNAT | Descriptor: | DIMETHYL SULFOXIDE, FdhC, SULFATE ION | Authors: | Salinger, A.J, Thoden, J.B, Holden, H.M. | Deposit date: | 2016-07-11 | Release date: | 2016-07-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily. Biochemistry, 55, 2016
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5KTD
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![BU of 5ktd by Molmil](/molmil-images/mine/5ktd) | FdhC with bound products: Coenzyme A and dTDP-3-amino-3,6-dideoxy-d-glucose | Descriptor: | 1,2-ETHANEDIOL, COENZYME A, FdhC, ... | Authors: | Salinger, A.J, Thoden, J.B, Holden, H.M. | Deposit date: | 2016-07-11 | Release date: | 2016-07-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily. Biochemistry, 55, 2016
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6MW6
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![BU of 6mw6 by Molmil](/molmil-images/mine/6mw6) | |
6Q1X
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![BU of 6q1x by Molmil](/molmil-images/mine/6q1x) | Lasso peptide pandonodin | Descriptor: | Pandonodin | Authors: | Link, A.J, Cheung-Lee, W.L. | Deposit date: | 2019-08-06 | Release date: | 2019-12-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail. Acs Chem.Biol., 14, 2019
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8DYM
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![BU of 8dym by Molmil](/molmil-images/mine/8dym) | Aspartimidylated Graspetide Amycolimiditide | Descriptor: | ATP-grasp target RiPP | Authors: | Link, A.J, Choi, B. | Deposit date: | 2022-08-04 | Release date: | 2022-11-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mechanistic Analysis of the Biosynthesis of the Aspartimidylated Graspetide Amycolimiditide. J.Am.Chem.Soc., 144, 2022
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6B5W
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![BU of 6b5w by Molmil](/molmil-images/mine/6b5w) | Benenodin-1-dC5, state 2 | Descriptor: | Benenodin-1 | Authors: | Link, A.J, Zong, C. | Deposit date: | 2017-09-29 | Release date: | 2017-10-18 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Lasso Peptide Benenodin-1 Is a Thermally Actuated [1]Rotaxane Switch J. Am. Chem. Soc., 139 (30), 2017
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7LL7
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![BU of 7ll7 by Molmil](/molmil-images/mine/7ll7) | [2]Catenane From MccJ25 Variant G12C G21C | Descriptor: | GLY-GLY-ALA-GLY-HIS-VAL-PRO-GLU-TYR-PHE, VAL-CYS-ILE-GLY-THR-PRO-ILE-SER-PHE-TYR-CYS | Authors: | Link, A.J, Schroeder, H.V. | Deposit date: | 2021-02-03 | Release date: | 2021-08-04 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides. Nat.Chem., 13, 2021
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7LCW
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![BU of 7lcw by Molmil](/molmil-images/mine/7lcw) | Aspartimidylated Lasso Peptide Lihuanodin | Descriptor: | Lasso Peptide Lihuanodin | Authors: | Link, A.J, Cao, L. | Deposit date: | 2021-01-11 | Release date: | 2021-07-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification. J.Am.Chem.Soc., 143, 2021
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7LI2
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![BU of 7li2 by Molmil](/molmil-images/mine/7li2) | Omega ester peptide pre-fuscimiditide | Descriptor: | Pre-fuscimiditide peptide | Authors: | Link, A.J, Elashal, H.E. | Deposit date: | 2021-01-26 | Release date: | 2022-02-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Biosynthesis and characterization of fuscimiditide, an aspartimidylated graspetide. Nat.Chem., 14, 2022
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7LIF
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![BU of 7lif by Molmil](/molmil-images/mine/7lif) | |
2N68
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![BU of 2n68 by Molmil](/molmil-images/mine/2n68) | |
5T56
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![BU of 5t56 by Molmil](/molmil-images/mine/5t56) | |
8VYC
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![BU of 8vyc by Molmil](/molmil-images/mine/8vyc) | |
7U4L
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![BU of 7u4l by Molmil](/molmil-images/mine/7u4l) | Crystal structure of human GPX4-U46C in complex with MAC-5576 | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase, thiophene-2-carbaldehyde | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2022-12-28 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4K
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![BU of 7u4k by Molmil](/molmil-images/mine/7u4k) | Crystal structure of human GPX4-U46C-R152H in complex with ML162 | Descriptor: | 1,2-ETHANEDIOL, 2-chloro-N-(3-chloro-4-methoxyphenyl)-N-[(1R)-2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl]acetamide, Phospholipid hydroperoxide glutathione peroxidase | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Xia, X, Soni, R.K, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4N
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![BU of 7u4n by Molmil](/molmil-images/mine/7u4n) | Crystal structure of human GPX4-U46C in complex with RSL3 | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase, methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Xia, X, Soni, R.K, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2022-12-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4M
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![BU of 7u4m by Molmil](/molmil-images/mine/7u4m) | Crystal structure of human GPX4-U46C in complex with LOC1886 | Descriptor: | 1,2-ETHANEDIOL, 4-methoxy-1H-indole-2-carbaldehyde, Phospholipid hydroperoxide glutathione peroxidase | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2022-12-28 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4J
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![BU of 7u4j by Molmil](/molmil-images/mine/7u4j) | Crystal structure of human GPX4-U46C-R152H in complex with TMT10 | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4I
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![BU of 7u4i by Molmil](/molmil-images/mine/7u4i) | Crystal structure of human GPX4-U46C-R152H in complex with CDS9 | Descriptor: | 2-bromo-N-[(thiophen-2-yl)methyl]acetamide, Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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6D0I
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![BU of 6d0i by Molmil](/molmil-images/mine/6d0i) | ParT: Prs ADP-ribosylating toxin bound to cognate antitoxin ParS. L48M ParT, SeMet-substituted complex. | Descriptor: | GLYCEROL, ParS: COG5642 (DUF2384) antitoxin fragment, ParT: COG5654 (RES domain) toxin | Authors: | Piscotta, F.J, Jeffrey, P.D, Link, A.J. | Deposit date: | 2018-04-10 | Release date: | 2019-01-09 | Last modified: | 2019-01-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6WY8
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![BU of 6wy8 by Molmil](/molmil-images/mine/6wy8) | Tcur3481-Tcur3483 steroid ACAD | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acyl-CoA dehydrogenase domain protein Tcur3481, Acyl-CoA dehydrogenase domain protein Tcur3483, ... | Authors: | Kimber, M.S, Stirling, A.J, Seah, S.Y.K. | Deposit date: | 2020-05-12 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Key Glycine in Bacterial Steroid-Degrading Acyl-CoA Dehydrogenases Allows Flavin-Ring Repositioning and Modulates Substrate Side Chain Specificity. Biochemistry, 59, 2020
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6WY9
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![BU of 6wy9 by Molmil](/molmil-images/mine/6wy9) | Tcur3481-Tcur3483 steroid ACAD G363A variant | Descriptor: | Acyl-CoA dehydrogenase domain protein Tcur3481, Acyl-CoA dehydrogenase domain protein Tcur3483, CHLORIDE ION, ... | Authors: | Kimber, M.S, Stirling, A.J, Seah, S.Y.K. | Deposit date: | 2020-05-12 | Release date: | 2020-10-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Key Glycine in Bacterial Steroid-Degrading Acyl-CoA Dehydrogenases Allows Flavin-Ring Repositioning and Modulates Substrate Side Chain Specificity. Biochemistry, 59, 2020
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4ZU5
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![BU of 4zu5 by Molmil](/molmil-images/mine/4zu5) | Crystal structure of the QdtA 3,4-Ketoisomerase from Thermoanaerobacterium thermosaccharolyticum, apo form | Descriptor: | (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, QdtA, THYMIDINE | Authors: | Thoden, J.B, Vinogradov, E, Gilbert, M, Salinger, A.J, Holden, H.M. | Deposit date: | 2015-05-15 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Bacterial Sugar 3,4-Ketoisomerases: Structural Insight into Product Stereochemistry. Biochemistry, 54, 2015
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