6POR

Antimicrobial lasso peptide ubonodin

Summary for 6POR

Entry DOI	10.2210/pdb6por/pdb
NMR Information	BMRB: 30625
Descriptor	Ubonodin (1 entity in total)
Functional Keywords	lasso peptide, ripps, antibiotic
Biological source	Burkholderia ubonensis
Total number of polymer chains	1
Total formula weight	3220.49
Authors	Link, A.J.,Cheung-Lee, W.L. (deposition date: 2019-07-05, release date: 2019-12-04, Last modification date: 2024-10-23)
Primary citation	Cheung-Lee, W.L.,Parry, M.E.,Zong, C.,Cartagena, A.J.,Darst, S.A.,Connell, N.D.,Russo, R.,Link, A.J. Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex. Chembiochem, 21:1335-1340, 2020 Cited by PubMed Abstract: We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis. The topology of ubonodin is unprecedented amongst lasso peptides, with 18 of its 28 amino acids found in the mechanically bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans, causative agents of lung infections in cystic fibrosis patients. PubMed: 31765515 DOI: 10.1002/cbic.201900707 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation