2JOH
 
 | |
4Y7K
 | | Structure of an archaeal mechanosensitive channel in closed state | | Descriptor: | Large conductance mechanosensitive channel protein,Riboflavin synthase | | Authors: | Li, J, Liu, Z. | | Deposit date: | 2015-02-15 | | Release date: | 2015-08-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4Y7J
 | | Structure of an archaeal mechanosensitive channel in expanded state | | Descriptor: | Large conductance mechanosensitive channel protein,Riboflavin synthase, nonyl beta-D-glucopyranoside | | Authors: | Li, J, Liu, Z. | | Deposit date: | 2015-02-15 | | Release date: | 2015-08-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
3FP4
 | | Crystal structure of Tom71 complexed with Ssa1 C-terminal fragment | | Descriptor: | CHLORIDE ION, SODIUM ION, SULFATE ION, ... | | Authors: | Li, J, Qian, X, Hu, J, Sha, B. | | Deposit date: | 2009-01-03 | | Release date: | 2009-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.
J.Biol.Chem., 284, 2009
|
|
2JOM
 | |
9JS4
 | | Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD | | Descriptor: | Heavy chain of 8G3, Light chain of 8G3, Spike glycoprotein | | Authors: | Li, J, Li, H. | | Deposit date: | 2024-09-30 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering.
Proc.Natl.Acad.Sci.USA, 122, 2025
|
|
1YZX
 | | Crystal structure of human kappa class glutathione transferase | | Descriptor: | Glutathione S-transferase kappa 1, L-GAMMA-GLUTAMYL-3-SULFINO-L-ALANYLGLYCINE | | Authors: | Li, J, Xia, Z, Ding, J. | | Deposit date: | 2005-02-28 | | Release date: | 2005-11-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme
PROTEIN SCI., 14, 2005
|
|
2JQW
 | |
9IV3
 | |
9IUR
 | |
9IV7
 | | Crystal structure of CcmS-CcmK1-CcmK2 complex from Synechocystis sp. PCC 6803 | | Descriptor: | Carboxysome shell protein CcmK1, Carboxysome shell protein CcmK2, D(-)-TARTARIC ACID, ... | | Authors: | Li, J, Deng, J.X, Jiang, Y.L, Zhou, C.Z. | | Deposit date: | 2024-07-23 | | Release date: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Assembly mechanism of beta-carboxysome shell mediated by the chaperone CcmS
To Be Published
|
|
4RLJ
 | | Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium tuberculosis | | Descriptor: | (3R)-hydroxyacyl-ACP dehydratase subunit HadA, (3R)-hydroxyacyl-ACP dehydratase subunit HadB, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... | | Authors: | Li, J, Dong, Y, Rao, Z.H. | | Deposit date: | 2014-10-17 | | Release date: | 2015-10-21 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.
Protein Cell, 6, 2015
|
|
4RLW
 | | Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium tuberculosis complexed with Butein | | Descriptor: | (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one, (3R)-hydroxyacyl-ACP dehydratase subunit HadA, (3R)-hydroxyacyl-ACP dehydratase subunit HadB, ... | | Authors: | Li, J, Dong, Y, Rao, Z.H. | | Deposit date: | 2014-10-18 | | Release date: | 2015-10-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.196 Å) | | Cite: | Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.
Protein Cell, 6, 2015
|
|
3T0H
 | |
3T0Z
 | | Hsp90 N-terminal domain bound to ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | | Authors: | Li, J. | | Deposit date: | 2011-07-21 | | Release date: | 2012-01-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.192 Å) | | Cite: | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90.
Acta Biochim Biophys Sin (Shanghai), 44, 2012
|
|
4RLU
 | | Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium tuberculosis complexed with 2',4,4'-trihydroxychalcone | | Descriptor: | (3R)-hydroxyacyl-ACP dehydratase subunit HadA, (3R)-hydroxyacyl-ACP dehydratase subunit HadB, 2',4,4'-TRIHYDROXYCHALCONE, ... | | Authors: | Li, J, Dong, Y, Rao, Z.H. | | Deposit date: | 2014-10-18 | | Release date: | 2015-10-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.198 Å) | | Cite: | Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.
Protein Cell, 6, 2015
|
|
9IVM
 | | Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex in the presence of LSN3318839 | | Descriptor: | (2~{R})-2-[2-[1-[(1~{R})-1-[2,6-bis(chloranyl)-3-cyclopropyl-phenyl]ethyl]imidazo[4,5-c]pyridin-6-yl]phenyl]propanoic acid, GLP-1(9-36), Glucagon-like peptide 1 receptor, ... | | Authors: | Li, J, Li, G, Mai, Y, Liu, X, Yang, D, Zhou, Q, Wang, M.-W. | | Deposit date: | 2024-07-24 | | Release date: | 2024-11-13 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839.
Acta Pharm Sin B, 14, 2024
|
|
9IVG
 | | Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex | | Descriptor: | GLP-1(9-36), Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Li, J, Li, G, Mai, Y, Liu, X, Yang, D, Zhou, Q, Wang, M.-W. | | Deposit date: | 2024-07-23 | | Release date: | 2024-11-27 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839.
Acta Pharm Sin B, 14, 2024
|
|
5XSS
 | | XylFII molecule | | Descriptor: | Periplasmic binding protein/LacI transcriptional regulator, beta-D-xylopyranose | | Authors: | Li, J.X, Wang, C.Y, Zhang, P. | | Deposit date: | 2017-06-15 | | Release date: | 2017-08-02 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.093 Å) | | Cite: | Molecular mechanism of environmental d-xylose perception by a XylFII-LytS complex in bacteria
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
3T1K
 | | HSP90 N-terminal domain bound to ANP | | Descriptor: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Li, J. | | Deposit date: | 2011-07-22 | | Release date: | 2012-01-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | HSP90 N-terminal domain bound to ANP
To be published
|
|
9K2C
 | | Structure of ClpP from Staphylococcus aureus in complex with ZY1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (6~{S},9~{a}~{S})-6-(1~{H}-imidazol-5-ylmethyl)-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-~{N}-(phenylmethyl)-3,6,9,9~{a}-tetrahydro-2~{H}-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, ... | | Authors: | Li, J.H, Wu, W, Zhang, T, Yang, C.-G. | | Deposit date: | 2024-10-17 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
J.Med.Chem., 68, 2025
|
|
9K2K
 | | Structure of ClpP from Staphylococcus aureus in complex with ZY7 | | Descriptor: | (6~{S},9~{a}~{S})-6-(2-methylpropyl)-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-~{N}-(phenylmethyl)-3,6,9,9~{a}-tetrahydro-2~{H}-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit | | Authors: | Li, J.H, Wu, W, Zhang, T, Yang, C.-G. | | Deposit date: | 2024-10-17 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
J.Med.Chem., 68, 2025
|
|
5XRE
 | | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1 | | Descriptor: | Heat shock protein HSP 90-alpha, N-[4-(4-methoxyphenyl)-3-[5-(8-methylquinolin-5-yl)-2,4-bis(oxidanyl)phenyl]-1,2-oxazol-5-yl]ethanamide | | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | | Deposit date: | 2017-06-08 | | Release date: | 2018-07-04 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.497 Å) | | Cite: | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1
To Be Published
|
|
5XQE
 | | Crystal structure of Human Hsp90 with FS3 | | Descriptor: | Heat shock protein HSP 90-alpha, N-[3-[5-chloranyl-2,4-bis(oxidanyl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]-2-methyl-propanamide | | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | | Deposit date: | 2017-06-07 | | Release date: | 2018-06-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.699 Å) | | Cite: | Crystal structure of Human Hsp90 with FS3
To Be Published
|
|
5XRD
 | |
