9IVG

Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex

Summary for 9IVG

• Entry DOI: 10.2210/pdb9ivg/pdb
• EMDB information: 60927
• Descriptor: GLP-1(9-36), Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
• Functional Keywords: glp-1(9-36), metabolite, allosteric modulation, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 156822.15

Authors

Li, J.,Li, G.,Mai, Y.,Liu, X.,Yang, D.,Zhou, Q.,Wang, M.-W. (deposition date: 2024-07-23, release date: 2024-11-27, Last modification date: 2024-12-25)

• Primary citation: Li, J.,Li, G.,Mai, Y.,Liu, X.,Yang, D.,Zhou, Q.,Wang, M.W.; Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839.; Acta Pharm Sin B, 14:5069-5073, 2024; PubMed: 39664415; DOI: 10.1016/j.apsb.2024.09.002

Experimental method

ELECTRON MICROSCOPY (3 Å)