8WA3
 
 | | Cryo-EM structure of peptide free and Gs-coupled GIPR | | Descriptor: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | Deposit date: | 2023-09-06 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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8WG8
 | | Cryo-EM structures of peptide free and Gs-coupled GCGR | | Descriptor: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | Deposit date: | 2023-09-20 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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8WG7
 | | Cryo-EM structures of peptide free and Gs-coupled GLP-1R | | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | Deposit date: | 2023-09-20 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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7EMC
 | | Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I | | Descriptor: | ALA-THR-GLU-ILE-ARG-GLU-LEU-LEU-VAL, Beta-2-microglobulin, Leucocyte antigen | | Authors: | Yue, C, Xiang, W, Huang, X, Sun, Y, Xiao, J, Liu, K, Sun, Z, Qiao, P, Li, H, Gan, J, Ba, L, Chai, Y, Qi, J, Liu, P, Qi, P, Zhao, Y, Li, Y, Qiu, H.J, Gao, G.F, Gao, G, Liu, W.J. | | Deposit date: | 2021-04-13 | | Release date: | 2021-12-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.
J.Virol., 96, 2022
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7EMB
 | | Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I | | Descriptor: | ALA-ALA-ALA-ILE-GLU-GLU-GLU-ASP-ILE, Beta-2-microglobulin, Leucocyte antigen | | Authors: | Yue, C, Xiang, W, Huang, X, Sun, Y, Xiao, J, Liu, K, Sun, Z, Qiao, P, Li, H, Gan, J, Ba, L, Chai, Y, Qi, J, Liu, P, Qi, P, Zhao, Y, Li, Y, Qiu, H.J, Gao, G.F, Gao, G, Liu, W.J. | | Deposit date: | 2021-04-13 | | Release date: | 2021-12-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.
J.Virol., 96, 2022
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7EMA
 | | Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I | | Descriptor: | Beta-2-microglobulin, Leucocyte antigen, TYR-SER-SER-ASP-VAL-THR-THR-LEU-VAL | | Authors: | Yue, C, Xiang, W, Huang, X, Sun, Y, Xiao, J, Liu, K, Sun, Z, Qiao, P, Li, H, Gan, J, Ba, L, Chai, Y, Qi, J, Liu, P, Qi, P, Zhao, Y, Li, Y, Qiu, H.J, Gao, G.F, Gao, G, Liu, W.J. | | Deposit date: | 2021-04-13 | | Release date: | 2021-12-08 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.
J.Virol., 96, 2022
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7EM9
 | | Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I | | Descriptor: | Beta-2-microglobulin, Leucocyte antigen, SER-LEU-ASP-GLU-TYR-SER-SER-ASP-VAL | | Authors: | Yue, C, Xiang, W, Huang, X, Sun, Y, Xiao, J, Liu, K, Sun, Z, Qiao, P, Li, H, Gan, J, Ba, L, Chai, Y, Qi, J, Liu, P, Qi, P, Zhao, Y, Li, Y, Qiu, H.J, Gao, G.F, Gao, G, Liu, W.J. | | Deposit date: | 2021-04-13 | | Release date: | 2021-12-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.
J.Virol., 96, 2022
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7EMD
 | | Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I | | Descriptor: | Beta-2-microglobulin, Leucocyte antigen, TYR-GLY-ASP-PHE-PHE-HIS-ASP-MET-VAL | | Authors: | Yue, C, Xiang, W, Huang, X, Sun, Y, Xiao, J, Liu, K, Sun, Z, Qiao, P, Li, H, Gan, J, Ba, L, Chai, Y, Qi, J, Liu, P, Qi, P, Zhao, Y, Li, Y, Qiu, H.J, Gao, G.F, Gao, G, Liu, W.J. | | Deposit date: | 2021-04-13 | | Release date: | 2021-12-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.
J.Virol., 96, 2022
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7F6V
 | | Cryo-EM structure of the human TACAN channel in a closed state | | Descriptor: | CHOLESTEROL, Ion channel TACAN | | Authors: | Chen, X.Z, Wang, Y.J, Li, Y, Yang, X, Shen, Y.Q. | | Deposit date: | 2021-06-25 | | Release date: | 2022-02-16 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Cryo-EM structure of the human TACAN in a closed state.
Cell Rep, 38, 2022
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8Q2Q
 | | Crystal structure of YTHDC1 in complex with Compound 2b (YL_32) | | Descriptor: | 2-chloranyl-~{N},9-dimethyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 | | Authors: | Bedi, R.K, Li, Y, Caflisch, A. | | Deposit date: | 2023-08-03 | | Release date: | 2023-12-06 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structure-Based Design of a Potent and Selective YTHDC1 Ligand.
J.Med.Chem., 67, 2024
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8Q2R
 | | Crystal structure of YTHDC1 in complex with Compound 3 (ZA_431) | | Descriptor: | 5-chloranyl-~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1 | | Authors: | Bedi, R.K, Zalesak, F, Li, Y, Caflisch, A. | | Deposit date: | 2023-08-03 | | Release date: | 2023-12-06 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure-Based Design of a Potent and Selective YTHDC1 Ligand.
J.Med.Chem., 67, 2024
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7CZ0
 | | Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb92) | | Descriptor: | ACETATE ION, CACODYLATE ION, CACODYLIC ACID, ... | | Authors: | Cai, H, Yao, H, Li, T, Hutter, C, Tang, Y, Li, Y, Seeger, M, Li, D. | | Deposit date: | 2020-09-06 | | Release date: | 2021-09-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | An improved fluorescent protein tag and its nanobodies for membrane protein expression, stability assay, and purification
To Be Published
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2AX1
 | | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee) | | Descriptor: | 5R-(3,4-DICHLOROPHENYLMETHYL)-3-(2-THIOPHENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | | Authors: | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | | Deposit date: | 2005-09-02 | | Release date: | 2006-01-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase.
J.Med.Chem., 49, 2006
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2AI3
 | | Purine nucleoside phosphorylase from calf spleen | | Descriptor: | (2S,4R,6R,6AS)-4-(2-AMINO-6-OXO-1,6-DIHYDROPURIN-9-YL)-6-(HYDROXYMETHYL)-TETRAHYDROFURO[3,4-D][1,3]DIOXOL-2-YLPHOSPHONI C ACID, MAGNESIUM ION, Purine nucleoside phosphorylase, ... | | Authors: | Toms, A.V, Wang, W, Li, Y, Ganem, B, Ealick, S.E. | | Deposit date: | 2005-07-28 | | Release date: | 2005-10-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.
Acta Crystallogr.,Sect.D, 61, 2005
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2B2X
 | | VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab | | Descriptor: | Antibody AQC2 Fab, Integrin alpha-1, MAGNESIUM ION | | Authors: | Clark, L.A, Boriack-Sjodin, P.A, Eldredge, J, Fitch, C, Friedman, B, Hanf, K.J, Jarpe, M, Liparoto, S.F, Li, Y, Lugovskoy, A. | | Deposit date: | 2005-09-19 | | Release date: | 2006-04-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design
Protein Sci., 15, 2006
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2AHU
 | | Crystal structure of Acyl-CoA transferase (YdiF) apoenzyme from Escherichia coli O157:H7. | | Descriptor: | putative enzyme ydiF | | Authors: | Rangarajan, E.S, Li, Y, Ajamian, E, Iannuzzi, P, Kernaghan, S.D, Fraser, M.E, Cygler, M, Matte, A, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | | Deposit date: | 2005-07-28 | | Release date: | 2005-11-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases.
J.Biol.Chem., 280, 2005
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3S44
 | | Crystal Structure of Pasteurella multocida sialyltransferase M144D mutant with CMP bound | | Descriptor: | Alpha-2,3/2,6-sialyltransferase/sialidase, CMP-3F(a)-Neu5Ac | | Authors: | Sugiarto, G, Lau, K, Li, Y, Lim, S, Ames, J.B, Le, D.-T, Fisher, A.J, Chen, X. | | Deposit date: | 2011-05-18 | | Release date: | 2012-08-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Directly Sialylating Lewis(x).
Acs Chem.Biol., 7, 2012
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3S6K
 | | Crystal structure of xcNAGS | | Descriptor: | Acetylglutamate kinase | | Authors: | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | Deposit date: | 2011-05-25 | | Release date: | 2012-04-18 | | Method: | X-RAY DIFFRACTION (2.8018 Å) | | Cite: | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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3S6G
 | | Crystal structures of Seleno-substituted mutant mmNAGS in space group P212121 | | Descriptor: | 1,2-ETHANEDIOL, COENZYME A, MALONATE ION, ... | | Authors: | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | Deposit date: | 2011-05-25 | | Release date: | 2012-04-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6681 Å) | | Cite: | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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2AI1
 | | Purine nucleoside phosphorylase from calf spleen | | Descriptor: | ((2R,4R,6R,6AS)-4-(2-AMINO-6-OXO-1,6-DIHYDROPURIN-9-YL)-6-(HYDROXYMETHYL)-TETRAHYDROFURO[3,4-D][1,3]DIOXOL-2-YL)METHYLPHOSPHONIC ACID, MAGNESIUM ION, Purine nucleoside phosphorylase, ... | | Authors: | Toms, A.V, Wang, W, Li, Y, Ganem, B, Ealick, S.E. | | Deposit date: | 2005-07-28 | | Release date: | 2005-10-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.
Acta Crystallogr.,Sect.D, 61, 2005
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3S6H
 | | Crystal structure of native mmNAGS/k | | Descriptor: | COENZYME A, GLUTAMIC ACID, N-acetylglutamate kinase / N-acetylglutamate synthase | | Authors: | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | Deposit date: | 2011-05-25 | | Release date: | 2012-04-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.102 Å) | | Cite: | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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2AX0
 | | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x) | | Descriptor: | 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | | Authors: | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | | Deposit date: | 2005-09-02 | | Release date: | 2006-01-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase.
J.Med.Chem., 49, 2006
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2AWZ
 | | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h) | | Descriptor: | 5R-(4-BROMOPHENYLMETHYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | | Authors: | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | | Deposit date: | 2005-09-02 | | Release date: | 2006-01-24 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase.
J.Med.Chem., 49, 2006
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2FD6
 | | Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A | | Descriptor: | 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... | | Authors: | Huang, M, Huai, Q, Li, Y. | | Deposit date: | 2005-12-13 | | Release date: | 2006-02-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311, 2006
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3S7Y
 | | Crystal structure of mmNAGS in Space Group P3121 at 4.3 A resolution | | Descriptor: | N-acetylglutamate kinase / N-acetylglutamate synthase | | Authors: | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | Deposit date: | 2011-05-27 | | Release date: | 2012-04-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (4.3077 Å) | | Cite: | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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