6ADQ
 
 | | Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis | | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | | Authors: | Gong, H.R, Xu, A, Gao, R.G, Ji, W.X, Wang, S.H, Wang, Q, Li, J, Rao, Z.H. | | Deposit date: | 2018-08-01 | | Release date: | 2018-11-14 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.
Science, 362, 2018
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1BWP
 | | PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | | Descriptor: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | | Authors: | Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z. | | Deposit date: | 1998-09-27 | | Release date: | 1999-05-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
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1BWR
 | | PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | | Descriptor: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | | Authors: | Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z. | | Deposit date: | 1998-09-27 | | Release date: | 1999-05-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
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7CA8
 | | The crystal structure of COVID-19 main protease in complex with an inhibitor Shikonin | | Descriptor: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | | Authors: | Zhou, X.L, Zhong, F.L, Lin, C, Li, J, Zhang, J. | | Deposit date: | 2020-06-08 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode.
Sci Bull (Beijing), 66, 2021
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5EJO
 | | Crystal structure of the winged helix domain in Chromatin assembly factor 1 subunit p90 | | Descriptor: | Chromatin assembly factor 1 subunit p90 | | Authors: | Zhang, K, Gao, Y, Li, J, Burgess, R, Han, J, Liang, H, Zhang, Z, Liu, Y. | | Deposit date: | 2015-11-02 | | Release date: | 2016-03-16 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks
Nucleic Acids Res., 44, 2016
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7MU8
 | | Structure of the minimally glycosylated human CEACAM1 N-terminal domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, ... | | Authors: | Belcher Dufrisne, M, Swope, N, Kieber, M, Yang, J.Y, Han, J, Li, J, Moremen, K.W, Prestegard, J.H, Columbus, L. | | Deposit date: | 2021-05-14 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Human CEACAM1 N-domain dimerization is independent from glycan modifications.
Structure, 30, 2022
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3QLE
 | | Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase | | Descriptor: | ACETATE ION, CALCIUM ION, PENTAETHYLENE GLYCOL, ... | | Authors: | Qian, X.G, Gebert, M, Hpker, J, Yan, M, Li, J.Z, Wiedemann, N, Laan, M.V.D, Pfanner, N, Sha, B.D. | | Deposit date: | 2011-02-02 | | Release date: | 2011-03-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.831 Å) | | Cite: | Structural basis for the function of tim50 in the mitochondrial presequence translocase.
J.Mol.Biol., 411, 2011
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6P49
 | | Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl2 | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | | Deposit date: | 2019-05-26 | | Release date: | 2019-07-24 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
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6P46
 | | Cryo-EM structure of TMEM16F in digitonin with calcium bound | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | | Deposit date: | 2019-05-26 | | Release date: | 2019-07-24 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
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6LTJ
 | | Structure of nucleosome-bound human BAF complex | | Descriptor: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | | Authors: | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | | Deposit date: | 2020-01-22 | | Release date: | 2020-02-12 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
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6P47
 | | Cryo-EM structure of TMEM16F in digitonin without calcium | | Descriptor: | Anoctamin-6 | | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | | Deposit date: | 2019-05-26 | | Release date: | 2019-07-24 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
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8HVN
 | | Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with PF07321332 | | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | | Authors: | Li, W.W, Zhang, J, Li, J. | | Deposit date: | 2022-12-27 | | Release date: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of SARS-Cov-2 main protease
P132H mutant in complex with PF07321332
To Be Published
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8IMG
 | | Human cGAS catalytic domain bound with C20 | | Descriptor: | 2-[2-hydroxy-2-oxoethyl-[3-(7-methoxy-4-methyl-2-oxidanylidene-chromen-3-yl)propanoyl]amino]ethanoic acid, Cyclic GMP-AMP synthase, ZINC ION | | Authors: | Zhao, W.F, Li, J.M, Xu, Y.C. | | Deposit date: | 2023-03-06 | | Release date: | 2024-01-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of novel cGAS inhibitors based on natural flavonoids.
Bioorg.Chem., 140, 2023
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6P48
 | | Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl1 | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | | Deposit date: | 2019-05-26 | | Release date: | 2019-07-24 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
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6IZQ
 | | PRMT4 bound with a bicyclic compound | | Descriptor: | (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol, Histone-arginine methyltransferase CARM1 | | Authors: | Xiong, B, Cao, D.Y, Guo, Z.H, Li, Y.L, Li, J, Huang, X, Shen, J.K. | | Deposit date: | 2018-12-20 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.449 Å) | | Cite: | Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
J.Med.Chem., 62, 2019
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2A5E
 | | SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE | | Descriptor: | TUMOR SUPPRESSOR P16INK4A | | Authors: | Byeon, I.-J.L, Li, J, Ericson, K, Selby, T.L, Tevelev, A, Kim, H.-J, O'Maille, P, Tsai, M.-D. | | Deposit date: | 1998-02-13 | | Release date: | 1999-08-13 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.
Mol.Cell, 1, 1998
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7KQ2
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8JR9
 | | Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R) | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ... | | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, He, X, Shan, H, Li, J, Wang, K, Li, Y, Hu, W, Wu, K, Shen, J, Xu, H.E. | | Deposit date: | 2023-06-16 | | Release date: | 2023-08-02 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (2.57 Å) | | Cite: | Conserved class B GPCR activation by a biased intracellular agonist.
Nature, 621, 2023
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1MI1
 | | Crystal Structure of the PH-BEACH Domain of Human Neurobeachin | | Descriptor: | Neurobeachin | | Authors: | Jogl, G, Shen, Y, Gebauer, D, Li, J, Wiegmann, K, Kashkar, H, Kroenke, M, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2002-08-21 | | Release date: | 2002-09-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain.
EMBO J., 21, 2002
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1ES9
 | | X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH) | | Descriptor: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB GAMMA SUBUNIT | | Authors: | McMullen, T.W.P, Li, J, Sheffield, P.J, Aoki, J, Martin, T.W, Arai, H, Inoue, K, Derewenda, Z.S. | | Deposit date: | 2000-04-07 | | Release date: | 2000-05-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib).
Protein Eng., 13, 2000
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7EG7
 | | TFIID-based core PIC on SCP promoter | | Descriptor: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2021-05-19 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EG9
 | | TFIID-based intermediate PIC on SCP promoter | | Descriptor: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2021-05-19 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EGA
 | | TFIID-based intermediate PIC on PUMA promoter | | Descriptor: | DNA (85-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2021-05-19 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EG8
 | | TFIID-based core PIC on PUMA promoter | | Descriptor: | DNA (85-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2021-05-19 | | Method: | ELECTRON MICROSCOPY (7.4 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EGI
 | | TFIID in rearranged conformation | | Descriptor: | TATA-box-binding protein, Transcription initiation factor IIA subunit 1, Transcription initiation factor IIA subunit 2, ... | | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-12 | | Method: | ELECTRON MICROSCOPY (9.82 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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