6IZQ
PRMT4 bound with a bicyclic compound
Summary for 6IZQ
Entry DOI | 10.2210/pdb6izq/pdb |
Descriptor | Histone-arginine methyltransferase CARM1, (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol (3 entities in total) |
Functional Keywords | histone-arginine methyltransferase carm1, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 151767.51 |
Authors | |
Primary citation | Guo, Z.,Zhang, Z.,Yang, H.,Cao, D.,Xu, X.,Zheng, X.,Chen, D.,Wang, Q.,Li, Y.,Li, J.,Du, Z.,Wang, X.,Chen, L.,Ding, J.,Shen, J.,Geng, M.,Huang, X.,Xiong, B. Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia. J.Med.Chem., 62:5414-5433, 2019 Cited by PubMed: 31117515DOI: 10.1021/acs.jmedchem.9b00297 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.449 Å) |
Structure validation
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