6IZQ
PRMT4 bound with a bicyclic compound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue XJ2 A 501 |
| Chain | Residue |
| A | PHE152 |
| A | HIS414 |
| A | TRP415 |
| A | TYR153 |
| A | GLN158 |
| A | MET162 |
| A | GLU257 |
| A | MET259 |
| A | TYR261 |
| A | GLU266 |
| A | MET268 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21410432 |
| Chain | Residue | Details |
| A | GLN159 | |
| B | GLU214 | |
| B | GLU243 | |
| B | SER271 | |
| C | GLN159 | |
| C | ARG168 | |
| C | GLY192 | |
| C | GLU214 | |
| C | GLU243 | |
| C | SER271 | |
| D | GLN159 | |
| A | ARG168 | |
| D | ARG168 | |
| D | GLY192 | |
| D | GLU214 | |
| D | GLU243 | |
| D | SER271 | |
| A | GLY192 | |
| A | GLU214 | |
| A | GLU243 | |
| A | SER271 | |
| B | GLN159 | |
| B | ARG168 | |
| B | GLY192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
| Chain | Residue | Details |
| A | SER216 | |
| B | SER216 | |
| C | SER216 | |
| D | SER216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 |
| Chain | Residue | Details |
| A | LYS227 | |
| B | LYS227 | |
| C | LYS227 | |
| D | LYS227 |
