4MZ4
 
 | | Discovery of an Irreversible HCV NS5B Polymerase Inhibitor | | Descriptor: | 1-[(2-chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase | | Authors: | Zeng, Q, Anilkumar, G.N, Rosenblum, S.B, Huang, H.-C, Lesburg, C.A, Jiang, Y, Selyutin, O, Chan, T.-Y, Bennett, F, Chen, K.X, Venkatraman, S, Sannigrahi, M, Velazquez, F, Duca, J.S, Gavalas, S, Huang, Y, Pu, H, Wang, L, Pinto, P, Vibulbhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Li, C, Hesk, D, Gesell, J, Sorota, S, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | | Deposit date: | 2013-09-29 | | Release date: | 2013-12-11 | | Last modified: | 2013-12-18 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Discovery of an irreversible HCV NS5B polymerase inhibitor.
Bioorg.Med.Chem.Lett., 23, 2013
|
|
4PE8
 | | Crystal structure of TatD in complex with trinucleotide DNA | | Descriptor: | DNA (5'-D(*GP*CP*T)-3'), Tat-linked quality control protein TatD | | Authors: | Chen, Y, Li, C.-L, Hsiao, Y.-Y, Duh, Y, Yuan, H.S. | | Deposit date: | 2014-04-23 | | Release date: | 2014-08-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.894 Å) | | Cite: | Structure and function of TatD exonuclease in DNA repair.
Nucleic Acids Res., 42, 2014
|
|
1Z23
 | | The serine-rich domain from Crk-associated substrate (p130Cas) | | Descriptor: | CRK-associated substrate | | Authors: | Briknarova, K, Nasertorabi, F, Havert, M.L, Eggleston, E, Hoyt, D.W, Li, C, Olson, A.J, Vuori, K, Ely, K.R. | | Deposit date: | 2005-03-07 | | Release date: | 2005-04-05 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle.
J.Biol.Chem., 280, 2005
|
|
4M8V
 | |
4P5U
 | | Crystal structure of TatD | | Descriptor: | Tat-linked quality control protein TatD | | Authors: | Chen, Y, Li, C.-L, Hsiao, Y.-Y, Duh, Y, Yuan, H.S. | | Deposit date: | 2014-03-20 | | Release date: | 2014-08-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and function of TatD exonuclease in DNA repair.
Nucleic Acids Res., 42, 2014
|
|
5C70
 | | The structure of Aspergillus oryzae beta-glucuronidase | | Descriptor: | Glucuronidase | | Authors: | Sun, H.L, Lv, B, Huang, S, Sun, Q.F, Li, C, Jiang, T. | | Deposit date: | 2015-06-24 | | Release date: | 2016-06-15 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Enhancing the Thermostability of beta-Glucuronidase by Rationally Redesigning the Catalytic Domain Based on Sequence Alignment Strategy
Ind Eng Chem Res, 55, 2016
|
|
4M9O
 | |
7E6Q
 | | Crystal structure of influenza A virus neuraminidase N5 complexed with 4'-phenyl-1,2,3-triazolylated oseltamivir carboxylate | | Descriptor: | (3R,4R,5S)-4-acetamido-3-pentan-3-yloxy-5-(4-phenyl-1,2,3-triazol-1-yl)cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Wang, P.F, Babayemi, O.O, Li, C.N, Fu, L.F, Zhang, S.S, Qi, J.X, Lv, X, Li, X.B. | | Deposit date: | 2021-02-23 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors.
Rsc Adv, 11, 2021
|
|
7ENQ
 | | Crystal structure of human NAMPT in complex with compound NAT | | Descriptor: | 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | | Authors: | Wang, G, Wu, C, Liu, M, Yao, H, Li, C, Wang, L, Tang, Y. | | Deposit date: | 2021-04-19 | | Release date: | 2022-05-04 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.204966 Å) | | Cite: | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity.
Cell Res., 32, 2022
|
|
6NBI
 | | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | | Deposit date: | 2018-12-07 | | Release date: | 2019-04-17 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
|
|
6NBH
 | | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | | Deposit date: | 2018-12-07 | | Release date: | 2019-04-17 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
|
|
6NBF
 | | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | | Deposit date: | 2018-12-07 | | Release date: | 2019-04-17 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
|
|
6AK1
 | | Crystal structure of DmoA from Hyphomicrobium sulfonivorans | | Descriptor: | Dimethyl-sulfide monooxygenase | | Authors: | Cao, H.Y, Wang, P, Peng, M, Li, C.Y. | | Deposit date: | 2018-08-28 | | Release date: | 2018-12-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.284 Å) | | Cite: | Crystal structure of the dimethylsulfide monooxygenase DmoA from Hyphomicrobium sulfonivorans.
Acta Crystallogr.,Sect.F, 74, 2018
|
|
2I8U
 | | GDP-mannose mannosyl hydrolase-calcium-GDP product complex | | Descriptor: | CALCIUM ION, GDP-mannose mannosyl hydrolase, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Zou, Y, Li, C, Brunzelle, J.S, Nair, S.K. | | Deposit date: | 2006-09-03 | | Release date: | 2007-06-19 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Molecular basis for substrate selectivity and specificity by an LPS biosynthetic enzyme
Biochemistry, 46, 2007
|
|
2I8T
 | | GDP-mannose mannosyl hydrolase-calcium-GDP-mannose complex | | Descriptor: | CALCIUM ION, GDP-mannose mannosyl hydrolase, GLYCEROL, ... | | Authors: | Zou, Y, Li, C, Brunzelle, J.S, Nair, S.K. | | Deposit date: | 2006-09-03 | | Release date: | 2007-06-19 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Molecular basis for substrate selectivity and specificity by an LPS biosynthetic enzyme
Biochemistry, 46, 2007
|
|
7VVX
 | | MmtN-SAH-Met complex | | Descriptor: | METHIONINE, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Zhang, Y.Z, Peng, M, Li, C.Y. | | Deposit date: | 2021-11-09 | | Release date: | 2022-04-20 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Insights into methionine S-methylation in diverse organisms.
Nat Commun, 13, 2022
|
|
7VVW
 | | MmtN-SAM complex | | Descriptor: | GLYCEROL, PHOSPHATE ION, S-ADENOSYLMETHIONINE, ... | | Authors: | Zhang, Y.Z, Peng, M, Li, C.Y. | | Deposit date: | 2021-11-09 | | Release date: | 2022-04-20 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Insights into methionine S-methylation in diverse organisms.
Nat Commun, 13, 2022
|
|
7VVV
 | | Crystal structure of MmtN | | Descriptor: | PHOSPHATE ION, SAM-dependent methyltransferase | | Authors: | Peng, M, Li, C.Y. | | Deposit date: | 2021-11-09 | | Release date: | 2022-04-20 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Insights into methionine S-methylation in diverse organisms.
Nat Commun, 13, 2022
|
|
7X7W
 | | The X-ray Crystallographic Structure of D-Psicose 3-epimerase from Clostridia bacterium | | Descriptor: | D-PSICOSE 3-EPIMERASE, MANGANESE (II) ION | | Authors: | Li, Z.F, Ban, X.F, Xie, X.F, Tian, Y.X, Li, C.M, Gu, Z.B. | | Deposit date: | 2022-03-10 | | Release date: | 2022-09-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Crystal structure of a novel homodimeric D-allulose 3-epimerase from a Clostridia bacterium
Acta Crystallogr.,Sect.D, 78, 2022
|
|
6A53
 | | Crystal structure of DddK | | Descriptor: | MANGANESE (II) ION, Novel protein with potential Cupin domain | | Authors: | Zhang, Y.Z, Li, C.Y. | | Deposit date: | 2018-06-21 | | Release date: | 2019-02-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.
Appl. Environ. Microbiol., 85, 2019
|
|
5EOD
 | | Human Plasma Coagulation FXI with peptide LP2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XI, LP2 | | Authors: | Wong, S.S, Ostergaard, S, Hall, G, Li, C, Williams, P.M, Stennicke, H, Emsley, J. | | Deposit date: | 2015-11-10 | | Release date: | 2016-04-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Blood, 127, 2016
|
|
4MPA
 | | Crystal structure of NHERF1-CXCR2 signaling complex in P21 space group | | Descriptor: | ACETIC ACID, CHLORIDE ION, Na(+)/H(+) exchange regulatory cofactor NHE-RF1, ... | | Authors: | Jiang, Y, Lu, G, Wu, Y, Brunzelle, J, Sirinupong, N, Li, C, Yang, Z. | | Deposit date: | 2013-09-12 | | Release date: | 2014-01-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.097 Å) | | Cite: | New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping.
Plos One, 8, 2013
|
|
7NFV
 | | Structure of SARS-CoV-2 Papain-like protease PLpro | | Descriptor: | CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Srinivasan, V, Gunther, S, Reinke, P, Werner, N, Falke, S, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Sprenger, J, Lieske, J, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Koua, F, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Ewert, W, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Ehrt, C, Rarey, M, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Hinrichs, W, Meents, A, Betzel, C. | | Deposit date: | 2021-02-07 | | Release date: | 2021-02-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022
|
|
4LMM
 | | Crystal structure of NHERF1 PDZ1 domain complexed with the CXCR2 C-terminal tail in P21 space group | | Descriptor: | ACETIC ACID, CHLORIDE ION, Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | | Authors: | Jiang, Y, Lu, G, Wu, Y, Brunzelle, J, Sirinupong, N, Li, C, Yang, Z. | | Deposit date: | 2013-07-10 | | Release date: | 2014-01-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping.
Plos One, 8, 2013
|
|
5IVL
 | | CshA Helicase | | Descriptor: | DEAD-box ATP-dependent RNA helicase CshA, SULFATE ION | | Authors: | Huen, J, Lin, C.-L, Yi, W.-L, Li, C.-L, Yuan, H. | | Deposit date: | 2016-03-21 | | Release date: | 2017-03-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Insights into a Unique Dimeric DEAD-Box Helicase CshA that Promotes RNA Decay.
Structure, 25, 2017
|
|
