4O9H
 
 | | Structure of Interleukin-6 in complex with a Camelid Fab fragment | | 分子名称: | Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7 | | 著者 | Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C. | | 登録日 | 2014-01-02 | | 公開日 | 2015-04-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
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3FE8
 | | Crystal structure of a pheromone binding protein from Apis mellifera with a serendipitous ligand soaked at pH 4.0 | | 分子名称: | (20S)-20-methyldotetracontane, CHLORIDE ION, GLYCEROL, ... | | 著者 | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | | 登録日 | 2008-11-28 | | 公開日 | 2009-12-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Queen bee pheromone binding protein pH induced domain-swapping favors pheromone release
To be Published
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1K3B
 | | Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SULFATE ION, ... | | 著者 | Turk, D, Janjic, V, Stern, I, Podobnik, M, Lamba, D, Dahl, S.W, Lauritzen, C, Pedersen, J, Turk, V, Turk, B. | | 登録日 | 2001-10-02 | | 公開日 | 2002-04-02 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases.
EMBO J., 20, 2001
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1YP7
 | | Van der Waals Interactions Dominate Hydrophobic Association in a Protein Binding Site Occluded From Solvent Water | | 分子名称: | CADMIUM ION, MAJOR URINARY PROTEIN 1 | | 著者 | Barratt, E, Bingham, R.J, Warner, D.J, Laughton, C.A, Phillips, S.E.V, Homans, S.W. | | 登録日 | 2005-01-30 | | 公開日 | 2005-08-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Van der Waals Interactions Dominate Ligand-Protein Association in a Protein Binding Site Occluded from Solvent Water
J.Am.Chem.Soc., 127, 2005
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4HEP
 | | Complex of lactococcal phage TP901-1 with a llama vHH (vHH17) binder (nanobody) | | 分子名称: | BPP, SULFATE ION, vHH17 domain | | 著者 | Desmyter, A, Spinelli, S, Farenc, C, Blangy, S, Bebeacua, C, van Sinderen, D, Mahony, J, Cambillau, C. | | 登録日 | 2012-10-04 | | 公開日 | 2013-03-20 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Viral infection modulation and neutralization by camelid nanobodies
Proc.Natl.Acad.Sci.USA, 110, 2013
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1LOA
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4R96
 | | Structure of a Llama Glama Fab 48A2 against human cMet | | 分子名称: | Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain | | 著者 | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | 登録日 | 2014-09-03 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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1ZRU
 | | structure of the lactophage p2 receptor binding protein in complex with glycerol | | 分子名称: | GLYCEROL, lactophage p2 receptor binding protein | | 著者 | Spinelli, S, Tremblay, D.M, Tegoni, M, Blangy, S, Huyghe, C, Desmyter, A, Labrie, S, de Haard, H, Moineau, S, Cambillau, C, Structural Proteomics in Europe (SPINE) | | 登録日 | 2005-05-22 | | 公開日 | 2006-03-28 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Receptor-binding protein of Lactococcus lactis phages: identification and characterization of the saccharide receptor-binding site.
J.Bacteriol., 188, 2006
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1QD0
 | | CAMELID HEAVY CHAIN VARIABLE DOMAINS PROVIDE EFFICIENT COMBINING SITES TO HAPTENS | | 分子名称: | 3-HYDROXY-7-(4-{1-[2-HYDROXY-3-(2-HYDROXY-5-SULFO-PHENYLAZO)-BENZYL]-2-SULFO-ETHYLAMINO}-[1,2,5]TRIAZIN-2-YLAMINO)-2-(2-HYDROXY-5-SULFO-PHENYLAZO)-NAPTHALENE-1,8-DISULFONIC ACID, COPPER (II) ION, VHH-R2 ANTI-RR6 ANTIBODY | | 著者 | Spinelli, S, Frenken, L.G.J, Hermans, P, Verrips, T, Brown, K, Tegoni, M, Cambillau, C. | | 登録日 | 1999-07-08 | | 公開日 | 2000-07-19 | | 最終更新日 | 2018-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Camelid heavy-chain variable domains provide efficient combining sites to haptens.
Biochemistry, 39, 2000
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4EQQ
 | | Structure of Ltp, a superinfection exclusion protein from the Streptococcus thermophilus temperate phage TP-J34 | | 分子名称: | PHOSPHATE ION, Putative host cell surface-exposed lipoprotein, SULFATE ION | | 著者 | Bebeacua, C, Lorenzo, C, Blangy, S, Spinelli, S, Heller, K, Cambillau, C. | | 登録日 | 2012-04-19 | | 公開日 | 2013-06-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | X-ray structure of a superinfection exclusion lipoprotein from phage TP-J34 and identification of the tape measure protein as its target.
Mol.Microbiol., 89, 2013
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2IWA
 | | Unbound glutaminyl cyclotransferase from Carica papaya. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLUTAMINE CYCLOTRANSFERASE, ... | | 著者 | Guevara, T, Mallorqui-Fernandez, N, Garcia-Castellanos, R, Petersen, G.E, Lauritzen, C, Pedersen, J, Arnau, J, Gomis-Ruth, F.X, Sola, M. | | 登録日 | 2006-06-27 | | 公開日 | 2006-07-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Papaya Glutamine Cyclotransferase Shows a Singular Five-Fold Beta-Propeller Architecture that Suggests a Novel Reaction Mechanism.
Biol.Chem., 387, 2006
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1O8C
 | | CRYSTAL STRUCTURE OF E. COLI K-12 YHDH WITH BOUND NADPH | | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, YHDH | | 著者 | Sulzenbacher, G, Roig-Zamboni, V, Pagot, F, Grisel, S, Salamoni, A, Valencia, C, Bignon, C, Vincentelli, R, Tegoni, M, Cambillau, C. | | 登録日 | 2002-11-26 | | 公開日 | 2004-05-21 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of Escherichia Coli Yhdh, a Putative Quinone Oxidoreductase
Acta Crystallogr.,Sect.D, 60, 2004
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1OKS
 | | Crystal structure of the measles virus phosphoprotein XD domain | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, RNA POLYMERASE ALPHA SUBUNIT | | 著者 | Johansson, K, Bourhis, J.-M, Campanacci, V, Cambillau, C, Canard, B, Longhi, S. | | 登録日 | 2003-07-29 | | 公開日 | 2003-09-01 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of the Measles Virus Phosphoprotein Domain Responsible for the Induced Folding of the C-Terminal Domain of the Nucleoprotein
J.Biol.Chem., 278, 2003
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1LOG
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1NIR
 | | OXYDIZED NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA | | 分子名称: | CHLORIDE ION, HEME C, HEME D, ... | | 著者 | Nurizzo, D, Tegoni, M, Cambillau, C. | | 登録日 | 1997-06-17 | | 公開日 | 1997-12-03 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | N-terminal arm exchange is observed in the 2.15 A crystal structure of oxidized nitrite reductase from Pseudomonas aeruginosa.
Structure, 5, 1997
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1KX9
 | | ANTENNAL CHEMOSENSORY PROTEIN A6 FROM THE MOTH MAMESTRA BRASSICAE | | 分子名称: | ACETATE ION, CHEMOSENSORY PROTEIN A6 | | 著者 | Lartigue, A, Campanacci, V, Roussel, A, Larsson, A.M, Jones, T.A, Tegoni, M, Cambillau, C. | | 登録日 | 2002-01-31 | | 公開日 | 2002-12-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | X-ray structure and ligand binding study of a moth chemosensory protein
J.Biol.Chem., 277, 2002
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1I3U
 | | THREE-DIMENSIONAL STRUCTURE OF A LLAMA VHH DOMAIN COMPLEXED WITH THE DYE RR1 | | 分子名称: | 5-(4,6-DIAMINO-[1,3,5]TRIAZIN-2-YLAMINO)-4-HYDROXY-3-(2-SULFO-PHENYLAZO)-NAPHTHALENE-2,7-DISULFONIC ACID, ANTIBODY VHH LAMA DOMAIN, SULFATE ION | | 著者 | Spinelli, S, Tegoni, M, Frenken, L, van Vliet, C, Cambillau, C. | | 登録日 | 2001-02-16 | | 公開日 | 2001-08-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Lateral recognition of a dye hapten by a llama VHH domain.
J.Mol.Biol., 311, 2001
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1I3V
 | | THREE-DIMENSIONAL STRUCTURE OF A LAMA VHH DOMAIN UNLIGANDED | | 分子名称: | ANTIBODY VHH LAMA DOMAIN | | 著者 | Spinelli, S, Tegoni, M, Frenken, L, van Vliet, C, Cambillau, C. | | 登録日 | 2001-02-16 | | 公開日 | 2001-08-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Lateral recognition of a dye hapten by a llama VHH domain.
J.Mol.Biol., 311, 2001
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1NNO
 | | CONFORMATIONAL CHANGES OCCURRING UPON NO BINDING IN NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA | | 分子名称: | HEME C, HEME D, NITRIC OXIDE, ... | | 著者 | Nurizzo, D, Tegoni, M, Cambillau, C. | | 登録日 | 1998-07-20 | | 公開日 | 1999-04-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Conformational changes occurring upon reduction and NO binding in nitrite reductase from Pseudomonas aeruginosa.
Biochemistry, 37, 1998
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1LOB
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1KX8
 | | Antennal Chemosensory Protein A6 from Mamestra brassicae, tetragonal form | | 分子名称: | CHEMOSENSORY PROTEIN A6 | | 著者 | Lartigue, A, Campanacci, V, Roussel, A, Larsson, A.M, Jones, T.A, Tegoni, M, Cambillau, C. | | 登録日 | 2002-01-31 | | 公開日 | 2002-12-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | X-Ray Structure and Ligand Binding Study of a Chemosensory Protein
J.Biol.Chem., 277, 2002
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1LCO
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1HZU
 | | DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA | | 分子名称: | HEME C, HEME D, NITRITE REDUCTASE | | 著者 | Brown, K, Cutruzzola, F, Brunori, M, Tegoni, M, Cambillau, C. | | 登録日 | 2001-01-26 | | 公開日 | 2001-09-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.
J.Mol.Biol., 312, 2001
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1HZV
 | | DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA | | 分子名称: | HEME C, HEME D, NITRIC OXIDE, ... | | 著者 | Brown, K, Tegoni, M, Cambillau, C. | | 登録日 | 2001-01-26 | | 公開日 | 2001-09-26 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.
J.Mol.Biol., 312, 2001
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4Y7M
 | | T6SS protein TssM C-terminal domain (835-1129) from EAEC | | 分子名称: | Hi113 protein, SULFATE ION, Type VI secretion protein IcmF | | 著者 | Nguyen, V.S, Spinelli, S, Durand, E, Roussel, A, Cambillau, C. | | 登録日 | 2015-02-15 | | 公開日 | 2015-08-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Biogenesis and structure of a type VI secretion membrane core complex.
Nature, 523, 2015
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