5WKZ
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![BU of 5wkz by Molmil](/molmil-images/mine/5wkz) | VH1-69 germline antibody predicted from CR6261 | Descriptor: | Immunoglobulin heavy variable 1-69D,IgG H chain, Lambda-chain (AA -20 to 215), SULFATE ION | Authors: | Lang, S, Lee, P.S. | Deposit date: | 2017-07-25 | Release date: | 2018-08-01 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Anti-idiotypic antibody K1-18 engages VH1-69 precursor and affinity-matured, anti-stem antibodies through mimicry of the HA stem To Be Published
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4L0J
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![BU of 4l0j by Molmil](/molmil-images/mine/4l0j) | Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems | Descriptor: | DNA helicase I, MAGNESIUM ION, SULFATE ION | Authors: | Redzej, A, Ilangovan, A, Lang, S, Gruber, C.J, Topf, M, Zangger, K, Zechner, E.L, Waksman, G. | Deposit date: | 2013-05-31 | Release date: | 2013-06-19 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems. Mol.Microbiol., 89, 2013
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6OCB
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![BU of 6ocb by Molmil](/molmil-images/mine/6ocb) | |
6OC3
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![BU of 6oc3 by Molmil](/molmil-images/mine/6oc3) | |
6OBZ
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![BU of 6obz by Molmil](/molmil-images/mine/6obz) | Crystal structure of FluA-20 Fab | Descriptor: | Heavy chain of FluA-20 Fab, Light chain of FluA-20 Fab, Immunoglobulin light chain | Authors: | Wilson, I.A, Lang, S. | Deposit date: | 2019-03-21 | Release date: | 2019-05-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface. Cell, 177, 2019
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4WEP
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![BU of 4wep by Molmil](/molmil-images/mine/4wep) | Apo YehZ from Escerichia coli | Descriptor: | Putative osmoprotectant uptake system substrate-binding protein OsmF | Authors: | Kimber, M.S, Lang, S, Mendoza, K, Wood, J.M. | Deposit date: | 2014-09-10 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter. Biochemistry, 54, 2015
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5WL2
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![BU of 5wl2 by Molmil](/molmil-images/mine/5wl2) | VH1-69 germline antibody with CDR H3 sequence of CR9114 | Descriptor: | Germline-reverted light chain of CR9114, Heavy chain of VH1-69 germline antibody with CDR H3 sequence of CR9114 | Authors: | Wilson, I.A, Lang, S. | Deposit date: | 2017-07-25 | Release date: | 2018-08-01 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Anti-idiotypic antibody K1-18 engages VH1-69 precursor and affinity-matured, anti-stem antibodies through mimicry of the HA stem. To Be Published
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5WKO
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4E9D
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![BU of 4e9d by Molmil](/molmil-images/mine/4e9d) | The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide | Descriptor: | 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide, GLYCEROL, Serine/threonine-protein kinase PLK1 | Authors: | Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C. | Deposit date: | 2012-03-21 | Release date: | 2012-10-10 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angew.Chem.Int.Ed.Engl., 51, 2012
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4E9C
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![BU of 4e9c by Molmil](/molmil-images/mine/4e9c) | The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, LDPPLHSpTA phosphopeptide, ... | Authors: | Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C. | Deposit date: | 2012-03-21 | Release date: | 2012-10-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angew. Chem. Int. Ed. Engl., 51, 2012
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4E67
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![BU of 4e67 by Molmil](/molmil-images/mine/4e67) | The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide | Descriptor: | Serine/threonine-protein kinase PLK1, hydrocinnamoyl-derivatized PLHSpTA peptide | Authors: | Sledz, P, Hyvonen, M, Tan, Y.S, Lang, S, Spring, D, Abell, C, Best, R.B. | Deposit date: | 2012-03-15 | Release date: | 2012-10-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1. Angew.Chem.Int.Ed.Engl., 51, 2012
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4AJY
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![BU of 4ajy by Molmil](/molmil-images/mine/4ajy) | von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide | Descriptor: | GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... | Authors: | Van Molle, I, Thomann, A, Buckley, D.L, So, E.C, Lang, S, Crews, C.M, Ciulli, A. | Deposit date: | 2012-02-21 | Release date: | 2012-11-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface. Chem.Biol., 19, 2012
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4AWJ
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![BU of 4awj by Molmil](/molmil-images/mine/4awj) | pVHL:EloB:EloC complex, in complex with capped Hydroxyproline | Descriptor: | (4R)-1-acetyl-4-hydroxy-N-methyl-L-prolinamide, ACETATE ION, ACETIC ACID, ... | Authors: | Van Molle, I, Thomann, A, Buckley, D.L, So, E.C, Lang, S, Crews, C.M, Ciulli, A. | Deposit date: | 2012-06-04 | Release date: | 2012-11-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface. Chem.Biol., 19, 2012
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2R15
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2F8V
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![BU of 2f8v by Molmil](/molmil-images/mine/2f8v) | Structure of full length telethonin in complex with the N-terminus of titin | Descriptor: | N2B-Titin Isoform, SULFATE ION, Telethonin | Authors: | Pinotsis, N, Petoukhov, M, Lange, S, Svergun, D, Zou, P, Gautel, M, Wilmanns, M. | Deposit date: | 2005-12-04 | Release date: | 2006-06-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J.Struct.Biol., 155, 2006
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2J8O
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![BU of 2j8o by Molmil](/molmil-images/mine/2j8o) | Structure of the immunoglobulin tandem repeat of titin A168-A169 | Descriptor: | GLYCEROL, TITIN | Authors: | Mueller, S, Lange, S, Kursula, I, Gautel, M, Wilmanns, M. | Deposit date: | 2006-10-26 | Release date: | 2007-08-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Rigid Conformation of an Immunoglobulin Domain Tandem Repeat in the A-Band of the Elastic Muscle Protein Titin J.Mol.Biol., 371, 2007
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2J8H
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![BU of 2j8h by Molmil](/molmil-images/mine/2j8h) | Structure of the immunoglobulin tandem repeat A168-A169 of titin | Descriptor: | GLYCEROL, TITIN | Authors: | Mueller, S, Lange, S, Kursula, I, Gautel, M, Wilmanns, M. | Deposit date: | 2006-10-25 | Release date: | 2007-08-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Rigid Conformation of an Immunoglobulin Domain Tandem Repeat in the A-Band of the Elastic Muscle Protein Titin J.Mol.Biol., 371, 2007
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4D0R
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![BU of 4d0r by Molmil](/molmil-images/mine/4d0r) | Mtb InhA complex with Pyradizinone compound 1 | Descriptor: | 4-(4-chlorophenoxy)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Read, J.A, Gingell, H, Madhavapeddi, P, Lange, S. | Deposit date: | 2014-04-29 | Release date: | 2015-05-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Pyridazinones: A Novel Scaffold with Excellent Physicochemical Properties and Safety Profile for a Clinically Validated Target of Mycobacterium Tuberculosis To be Published
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4D0S
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![BU of 4d0s by Molmil](/molmil-images/mine/4d0s) | Mtb InhA complex with Pyradizinone compound 14 | Descriptor: | 1-{4-[(acetylamino)methyl]phenyl}-4-(4-chlorophenoxy)-6-oxo-1,6-dihydropyridazine-3-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], MAGNESIUM ION, ... | Authors: | Read, J.A, Breed, J, Madhavapeddi, P, Lange, S. | Deposit date: | 2014-04-29 | Release date: | 2015-05-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Pyridazinones: A Novel Scaffold with Excellent Physicochemical Properties and Safety Profile for a Clinically Validated Target of Mycobacterium Tuberculosis To be Published
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1K1G
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![BU of 1k1g by Molmil](/molmil-images/mine/1k1g) | STRUCTURAL BASIS FOR RECOGNITION OF THE INTRON BRANCH SITE RNA BY SPLICING FACTOR 1 | Descriptor: | 5'-R(*UP*AP*UP*AP*CP*UP*AP*AP*CP*AP*A)-3', SF1-Bo isoform | Authors: | Liu, Z, Luyten, I, Bottomley, M.J, Messias, A.C, Houngninou-Molango, S, Sprangers, R, Zanier, K, Kramer, A, Sattler, M. | Deposit date: | 2001-09-25 | Release date: | 2001-11-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural basis for recognition of the intron branch site RNA by splicing factor 1. Science, 294, 2001
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4V96
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![BU of 4v96 by Molmil](/molmil-images/mine/4v96) | The structure of a 1.8 MDa viral genome injection device suggests alternative infection mechanisms | Descriptor: | BPP, ORF46, ORF48 | Authors: | Veesler, D, Spinelli, S, Mahony, J, Lichiere, J, Blangy, S, Bricogne, G, Legrand, P, Ortiz-Lombardia, M, Campanacci, V, van Sinderen, D, Cambillau, C. | Deposit date: | 2012-02-01 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism. Proc.Natl.Acad.Sci.USA, 109, 2012
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4IOS
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![BU of 4ios by Molmil](/molmil-images/mine/4ios) | Structure of phage TP901-1 RBP (ORF49) in complex with nanobody 11. | Descriptor: | BPP, GLYCEROL, Llama nanobody 11 | Authors: | Desmyter, A, Farenc, C, Mahony, J, Spinelli, S, Bebeacua, C, Blangy, S, Veesler, D, van Sinderen, D, Cambillau, C. | Deposit date: | 2013-01-08 | Release date: | 2013-03-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Viral infection modulation and neutralization by camelid nanobodies Proc.Natl.Acad.Sci.USA, 110, 2013
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4RGA
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![BU of 4rga by Molmil](/molmil-images/mine/4rga) | Phage 1358 receptor binding protein in complex with the trisaccharide GlcNAc-Galf-GlcOMe | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-galactofuranose-(1-6)-methyl alpha-D-glucopyranoside, Phage 1358 receptor binding protein (ORF20) | Authors: | Spinelli, S, Mccabe, O, Farenc, C, Tremblay, D, Blangy, S, Oscarson, S, Moineau, S, Cambillau, C. | Deposit date: | 2014-09-29 | Release date: | 2015-05-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The targeted recognition of Lactococcus lactis phages to their polysaccharide receptors. Mol.Microbiol., 96, 2015
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3HG0
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![BU of 3hg0 by Molmil](/molmil-images/mine/3hg0) | Crystal structure of a DARPin in complex with ORF49 from Lactococcal phage TP901-1 | Descriptor: | Baseplate protein, Designed Ankyrin Repeat Protein (DARPin) 20 | Authors: | Veesler, D, Dreier, B, Blangy, S, Lichiere, J, Tremblay, D, Moineau, S, Spinelli, S, Tegoni, M, Pluckthun, A, Campanacci, V, Cambillau, C. | Deposit date: | 2009-05-13 | Release date: | 2009-09-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode. J.Biol.Chem., 284, 2009
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6YRV
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![BU of 6yrv by Molmil](/molmil-images/mine/6yrv) | Crystal structure of FAP after illumination at 100K | Descriptor: | CARBON DIOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, Fatty acid Photodecarboxylase, ... | Authors: | Sorigue, D, Gotthard, G, Blangy, S, Nurizzo, D, Royant, A, Beisson, F, Arnoux, P. | Deposit date: | 2020-04-20 | Release date: | 2021-04-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Mechanism and dynamics of fatty acid photodecarboxylase. Science, 372, 2021
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