6NYY
 
 | | human m-AAA protease AFG3L2, substrate-bound | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AFG3-like protein 2, MAGNESIUM ION, ... | | 著者 | Lander, G.C, Puchades, C. | | 登録日 | 2019-02-12 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
Mol.Cell, 75, 2019
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8FFY
 | | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL) | | 分子名称: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ... | | 著者 | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | | 登録日 | 2022-12-11 | | 公開日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition.
Nat Commun, 14, 2023
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7S66
 | | Extended conformation of nighttime state KaiC | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION | | 著者 | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
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7S67
 | | Extended conformation of daytime state KaiC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ... | | 著者 | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
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7S65
 | | Compressed conformation of nighttime state KaiC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ... | | 著者 | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
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6XMJ
 | | Human 20S proteasome bound to an engineered 11S (PA26) activator | | 分子名称: | Proteasome activator protein PA26, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | | 著者 | de la Pena, A.H, Opoku-Nsiah, K.A, Williams, S.K, Chopra, N, Sali, A, Gestwicki, J.E, Lander, G.C. | | 登録日 | 2020-06-30 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The Y Phi motif defines the structure-activity relationships of human 20S proteasome activators.
Nat Commun, 13, 2022
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3KO1
 | | Cystal structure of thermosome from Acidianus tengchongensis strain S5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin | | 著者 | Huo, Y, Zhang, K, Hu, Z, Wang, L, Zhai, Y, Zhou, Q, Lander, G, He, Y, Zhu, J, Xu, W, Dong, Z, Sun, F. | | 登録日 | 2009-11-12 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Crystal structure of group II chaperonin in the open state.
Structure, 18, 2010
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6WHI
 | | Cryo-electron microscopy structure of the type I-F CRISPR RNA-guided surveillance complex bound to the anti-CRISPR AcrIF9 | | 分子名称: | CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, CRISPR-associated protein Csy3, ... | | 著者 | Hirschi, M, Santiago-Frangos, A, Wilkinson, R, Golden, S.M, Wiedenheft, B, Lander, G. | | 登録日 | 2020-04-08 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex.
Nat Commun, 11, 2020
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6W1X
 | | Cryo-EM structure of anti-CRISPR AcrIF9, bound to the type I-F crRNA-guided CRISPR surveillance complex | | 分子名称: | CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, CRISPR-associated protein Csy3, ... | | 著者 | Hirschi, M, Santiago-Frangos, A, Wilkinson, R, Golden, S.M, Wiedenheft, B, Lander, G. | | 登録日 | 2020-03-04 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex.
Nat Commun, 11, 2020
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8FLJ
 | | Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA | | 分子名称: | CRISPR leader and repeat, anti-sense strand of DNA, CRISPR leader, ... | | 著者 | Santiago-Frangos, A, Henriques, W.S, Wiegand, T, Gauvin, C, Buyukyoruk, M, Neselu, K, Eng, E.T, Lander, G.C, Wiedenheft, B. | | 登録日 | 2022-12-21 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays.
Nat.Struct.Mol.Biol., 30, 2023
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7U2B
 | | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(GCU-TL) | | 分子名称: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (53-MER), Serine--tRNA ligase, ... | | 著者 | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | | 登録日 | 2022-02-23 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
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6V20
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6V11
 | | Lon Protease from Yersinia pestis | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | 著者 | Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. | | 登録日 | 2019-11-19 | | 公開日 | 2020-01-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
Sci Adv, 6, 2020
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9C0C
 | | E.coli GroEL apoenzyme | | 分子名称: | 60 kDa chaperonin | | 著者 | Watson, E.R, Lander, G.C. | | 登録日 | 2024-05-25 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target.
J.Am.Chem.Soc., 146, 2024
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9CC0
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9CLP
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9C0D
 | | E.Faecium GroEL | | 分子名称: | Chaperonin GroEL | | 著者 | Watson, E.R, Lander, G.C. | | 登録日 | 2024-05-25 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target.
J.Am.Chem.Soc., 146, 2024
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7U2A
 | | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU) | | 分子名称: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ... | | 著者 | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | | 登録日 | 2022-02-23 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
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6AZ0
 | | Mitochondrial ATPase Protease YME1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Puchades, C, Rampello, A.J, Shin, M, Giuliano, C, Wiseman, R.L, Glynn, S.E, Lander, G.C. | | 登録日 | 2017-09-09 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.
Science, 358, 2017
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9CC3
 | | Human Mitochondrial LONP1 Stall State + casein | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Endogenous Co-purified substrate modeled as unknown residues, Lon protease homolog, ... | | 著者 | Mindrebo, J.T, Lander, G.C. | | 登録日 | 2024-06-20 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism.
Biorxiv, 2024
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9C0B
 | | E.coli GroEL + PBZ1587 inhibitor | | 分子名称: | 60 kDa chaperonin, N-(2-{4-[4-(aminomethyl)benzene-1-sulfonamido]phenyl}-1,3-benzoxazol-5-yl)-5-chlorothiophene-2-sulfonamide | | 著者 | Watson, E.R, Lander, G.C. | | 登録日 | 2024-05-25 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target.
J.Am.Chem.Soc., 146, 2024
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6V21
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6BPQ
 | | Structure of the cold- and menthol-sensing ion channel TRPM8 | | 分子名称: | Transient receptor potential cation channel subfamily M member 8 | | 著者 | Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y. | | 登録日 | 2017-11-25 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structure of the cold- and menthol-sensing ion channel TRPM8.
Science, 359, 2018
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7SXO
 | | Yeast Lon (PIM1) with endogenous substrate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | | 著者 | Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. | | 登録日 | 2021-11-24 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.
J.Biol.Chem., 298, 2022
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8D7X
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