9CLP

Structure of ecarin from the venom of Kenyan saw-scaled viper in complex with the Fab of neutralizing antibody H11

Summary for 9CLP

Entry DOI	10.2210/pdb9clp/pdb
EMDB information	45728
Descriptor	Zinc metalloproteinase-disintegrin-like ecarin, Endogenous peptide, H11 Fab heavy chain, ... (6 entities in total)
Functional Keywords	snake venom metalloproteinase, neutralizing antibody, hydrolase
Biological source	Echis carinatus (Saw-scaled viper) More
Total number of polymer chains	4
Total formula weight	94974.02
Authors	Mindrebo, J.T.,Lander, G.C. (deposition date: 2024-07-12, release date: 2024-09-11)
Primary citation	Misson Mindrebo, L.E.,Mindrebo, J.T.,Tran, Q.,Wilkinson, M.C.,Smith, J.M.,Verma, M.,Casewell, N.R.,Lander, G.C.,Jardine, J.G. Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies. Toxins, 16:-, 2024 Cited by PubMed: 39195771 DOI: 10.3390/toxins16080361 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.43 Å)

Structure validation