4OUF
| Crystal Structure of CBP bromodomain | Descriptor: | 1,2-ETHANEDIOL, CREB-binding protein, DI(HYDROXYETHYL)ETHER | Authors: | Roy, S, Das, C, Tyler, J.K, Kutateladze, T.G. | Deposit date: | 2014-02-17 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. Proc.Natl.Acad.Sci.USA, 111, 2014
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7RGW
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3C6W
| Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptide | Descriptor: | H3K4me3 histone peptide, Inhibitor of growth protein 5, ZINC ION | Authors: | Champagne, K.S, Pena, P.V, Johnson, K, Kutateladze, T.G. | Deposit date: | 2008-02-05 | Release date: | 2008-06-03 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. Proteins, 72, 2008
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3LH0
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4X34
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3RCP
| Crystal structure of the FAPP1 pleckstrin homology domain | Descriptor: | GLYCEROL, Pleckstrin homology domain-containing family A member 3 | Authors: | Roy, S, He, J, Kutateladze, T.G. | Deposit date: | 2011-03-31 | Release date: | 2011-04-20 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain. J.Biol.Chem., 286, 2011
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6X7D
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8E4V
| Solution structure of the WH domain of MORF | Descriptor: | Isoform 3 of Histone acetyltransferase KAT6B | Authors: | Zhang, Y, Kutateladze, T.G. | Deposit date: | 2022-08-19 | Release date: | 2023-05-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain. Nat Commun, 14, 2023
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8U2Y
| Solution structure of the PHD6 finger of MLL4 bound to TET3 | Descriptor: | Histone-lysine N-methyltransferase 2D, Methylcytosine dioxygenase TET3, ZINC ION | Authors: | Mohid, S.A, Zandian, M, Zhang, Y, Kutateladze, T.G. | Deposit date: | 2023-09-06 | Release date: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | MLL4 binds TET3. Structure, 32, 2024
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7UHE
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8U77
| Crystal structure of Taf14 in complex with Yng1 | Descriptor: | Protein YNG1, Transcription initiation factor TFIID subunit 14 | Authors: | Nguyen, M.C, Wei, P.C, Zhang, G.Y, Kutateladze, T.G. | Deposit date: | 2023-09-14 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex. Nat Commun, 15, 2024
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6AXJ
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8GDX
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8GE0
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4HCZ
| PHF1 Tudor in complex with H3K36me3 | Descriptor: | H3L-like histone, PHD finger protein 1 | Authors: | Musselman, C.A, Roy, S, Nunez, J, Kutateladze, T.G. | Deposit date: | 2012-10-01 | Release date: | 2012-11-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat.Struct.Mol.Biol., 19, 2012
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5D7E
| Crystal structure of Taf14 YEATS domain in complex with H3K9ac | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, H3K9ac, ... | Authors: | Andrews, F.H, Shanle, E.K, Strahl, B.D, Kutateladze, T.G. | Deposit date: | 2015-08-13 | Release date: | 2015-09-23 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Genes Dev., 29, 2015
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1R48
| Solution structure of the C-terminal cytoplasmic domain residues 468-497 of Escherichia coli protein ProP | Descriptor: | Proline/betaine transporter | Authors: | Zoetewey, D.L, Tripet, B.P, Kutateladze, T.G, Overduin, M.J, Wood, J.M, Hodges, R.S. | Deposit date: | 2003-10-03 | Release date: | 2003-12-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of the C-terminal Antiparallel Coiled-coil Domain from Escherichia coli Osmosensor ProP. J.Mol.Biol., 334, 2003
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7W9V
| Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I) | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Hatazawa, S, Liu, J, Takizawa, Y, Zandian, M, Negishi, L, Kutateladze, T.G, Kurumizaka, H. | Deposit date: | 2021-12-10 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. Iscience, 25, 2022
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5ERC
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4L58
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4L7X
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6WW3
| Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SUMO1 linked HERC2 ZZ domain (Small ubiquitin-related modifier 1,E3 ubiquitin-protein ligase HERC2), ... | Authors: | Liu, J, Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-07 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.096 Å) | Cite: | Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure, 28, 2020
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6WW8
| BRD4 Bromodomain 1 in complex with triple CDK4/6-PI3K-BET inhibitor | Descriptor: | 7-cyclopentyl-N,N-dimethyl-2-({4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Bromodomain-containing protein 4 | Authors: | Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-08 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov, 6, 2020
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6X7B
| BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P | Descriptor: | 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4 | Authors: | Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-29 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.951 Å) | Cite: | Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020
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6X7C
| BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212 | Descriptor: | 7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4 | Authors: | Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-29 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020
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