2G6Q
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2GP5
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![BU of 2gp5 by Molmil](/molmil-images/mine/2gp5) | Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, FE (II) ION, Jumonji domain-containing protein 2A, ... | Authors: | Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G. | Deposit date: | 2006-04-16 | Release date: | 2006-05-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006
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2GP3
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![BU of 2gp3 by Molmil](/molmil-images/mine/2gp3) | Crystal structure of the catalytic core domain of jmjd2a | Descriptor: | FE (II) ION, Jumonji domain-containing protein 2A, ZINC ION | Authors: | Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G. | Deposit date: | 2006-04-16 | Release date: | 2006-05-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006
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2QIC
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![BU of 2qic by Molmil](/molmil-images/mine/2qic) | Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide | Descriptor: | H3K4ME3 PEPTIDE, Inhibitor of growth protein 1, ZINC ION | Authors: | Pena, P.V, Champagne, K, Zhao, R, Kutateladze, T.G. | Deposit date: | 2007-07-03 | Release date: | 2008-05-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J.Mol.Biol., 380, 2008
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2PNX
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6MIU
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6MJ7
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![BU of 6mj7 by Molmil](/molmil-images/mine/6mj7) | Crystal structure of p62 ZZ domain in complex with free arginine | Descriptor: | 1,4-DIETHYLENE DIOXIDE, ARGININE, Sequestosome-1, ... | Authors: | Ahn, J, Zhang, Y, Kutateladze, T.G. | Deposit date: | 2018-09-20 | Release date: | 2018-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.412 Å) | Cite: | ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun, 9, 2018
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6WW4
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![BU of 6ww4 by Molmil](/molmil-images/mine/6ww4) | Crystal structure of HERC2 ZZ domain in complex with histone H3 tail | Descriptor: | GLYCEROL, Histone H3.1,E3 ubiquitin-protein ligase HERC2, ZINC ION | Authors: | Liu, J, Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-07 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.252 Å) | Cite: | Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure, 28, 2020
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6WW3
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![BU of 6ww3 by Molmil](/molmil-images/mine/6ww3) | Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SUMO1 linked HERC2 ZZ domain (Small ubiquitin-related modifier 1,E3 ubiquitin-protein ligase HERC2), ... | Authors: | Liu, J, Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-07 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.096 Å) | Cite: | Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure, 28, 2020
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6WW8
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![BU of 6ww8 by Molmil](/molmil-images/mine/6ww8) | BRD4 Bromodomain 1 in complex with triple CDK4/6-PI3K-BET inhibitor | Descriptor: | 7-cyclopentyl-N,N-dimethyl-2-({4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Bromodomain-containing protein 4 | Authors: | Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-08 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov, 6, 2020
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6X7B
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![BU of 6x7b by Molmil](/molmil-images/mine/6x7b) | BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P | Descriptor: | 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4 | Authors: | Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-29 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.951 Å) | Cite: | Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020
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6X7C
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![BU of 6x7c by Molmil](/molmil-images/mine/6x7c) | BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212 | Descriptor: | 7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4 | Authors: | Vann, K.R, Kutateladze, T.G. | Deposit date: | 2020-05-29 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020
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6X7D
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5SVX
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5SVY
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![BU of 5svy by Molmil](/molmil-images/mine/5svy) | MORC3 CW in complex with histone H3K4me1 | Descriptor: | ACETATE ION, H3K4me1, MORC family CW-type zinc finger protein 3, ... | Authors: | Tong, Q, Andrews, F.H, Kutateladze, T.G. | Deposit date: | 2016-08-08 | Release date: | 2016-10-05 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Cell Rep, 16, 2016
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5TDW
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![BU of 5tdw by Molmil](/molmil-images/mine/5tdw) | Set3 PHD finger in complex with histone H3K4me3 | Descriptor: | SET domain-containing protein 3, SODIUM ION, ZINC ION, ... | Authors: | Andrews, F.H, Ali, M, Kutateladze, T.G. | Deposit date: | 2016-09-19 | Release date: | 2016-10-19 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J. Mol. Biol., 429, 2017
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5TAB
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5SVI
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5TDR
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![BU of 5tdr by Molmil](/molmil-images/mine/5tdr) | Set3 PHD finger in complex with histone H3K4me2 | Descriptor: | Histone H3, SET domain-containing protein 3, SODIUM ION, ... | Authors: | Andrews, F.H, Ali, M, Kutateladze, T.G. | Deposit date: | 2016-09-19 | Release date: | 2016-11-02 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J. Mol. Biol., 429, 2017
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5U2F
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5U2E
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5U2C
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5U2J
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5U28
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![BU of 5u28 by Molmil](/molmil-images/mine/5u28) | BRD4 first bromodomain (BD1) in complex with dual PI3 kinase inhibitor SF2523 | Descriptor: | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one, Bromodomain-containing protein 4, DI(HYDROXYETHYL)ETHER, ... | Authors: | Andrews, F.H, Kutateladze, T.G. | Deposit date: | 2016-11-30 | Release date: | 2017-02-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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