Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide

Summary for 2QIC

DescriptorInhibitor of growth protein 1, H3K4ME3 PEPTIDE, ZINC ION, ... (4 entities in total)
Functional Keywordsphd, ing1, histone, h3k4me3, chromatin, antitumor protein, apoptosis
Biological sourceHomo sapiens (human)
Cellular locationNucleus (Probable) Q9UK53
Total number of polymer chains2
Total molecular weight8557.31
Pena, P.V.,Champagne, K.,Zhao, R.,Kutateladze, T.G. (deposition date: 2007-07-03, release date: 2008-05-13, Last modification date: 2011-07-13)
Primary citation
Pena, P.V.,Hom, R.A.,Hung, T.,Lin, H.,Kuo, A.J.,Wong, R.P.,Subach, O.M.,Champagne, K.S.,Zhao, R.,Verkhusha, V.V.,Li, G.,Gozani, O.,Kutateladze, T.G.
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
J.Mol.Biol., 380:303-312, 2008
PubMed: 18533182 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2008.04.061
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers802.0%10.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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