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PDB: 98 件
3QHT
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BU of 3qht by Molmil
Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO
分子名称: GLYCEROL, Monobody ySMB-1, Ubiquitin-like protein SMT3
著者Koide, S, Gilbreth, R.N.
登録日2011-01-26
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.
Proc.Natl.Acad.Sci.USA, 108, 2011
5V7P
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BU of 5v7p by Molmil
Atomic structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase), in complex with a monobody
分子名称: DECANE, Protein-S-isoprenylcysteine O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Long, S.B, Diver, M.M, Pedi, L, Koide, A, Koide, S.
登録日2017-03-20
公開日2018-01-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
Nature, 553, 2018
4IOF
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BU of 4iof by Molmil
Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)
分子名称: Fab-bound IDE, heavy chain, light chain, ...
著者McCord, L.A, Liang, W.G, Hoey, R, Dowdell, E, Koide, A, Koide, S, Tang, W.J.
登録日2013-01-07
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.353 Å)
主引用文献Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
Proc.Natl.Acad.Sci.USA, 110, 2013
6CPG
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BU of 6cpg by Molmil
Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation
分子名称: 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea, Aurora kinase A, Monobody
著者Otten, R, Kutter, S, Zorba, A, Padua, R.A.P, Koide, A, Koide, S, Kern, D.
登録日2018-03-13
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Dynamics of human protein kinase Aurora A linked to drug selectivity.
Elife, 7, 2018
2AF5
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BU of 2af5 by Molmil
2.5A X-ray Structure of Engineered OspA protein
分子名称: Engineered Outer Surface Protein A (OspA) with the inserted two beta-hairpins
著者Makabe, K, Mcelheny, D, Tereshko, V, Hilyard, A, Koide, A, Koide, S.
登録日2005-07-25
公開日2006-08-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Atomic structures of peptide self-assembly mimics.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5CWW
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BU of 5cww by Molmil
Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complex
分子名称: Nucleoporin NUP145N, Nucleoporin NUP159, Nucleoporin NUP82
著者Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A.
登録日2015-07-28
公開日2015-09-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
5CWV
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BU of 5cwv by Molmil
Crystal structure of Chaetomium thermophilum Nup192 TAIL domain
分子名称: Nucleoporin NUP192
著者Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A.
登録日2015-07-28
公開日2015-09-16
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3.155 Å)
主引用文献Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
5CWU
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BU of 5cwu by Molmil
Crystal structure of Chaetomium thermophilum Nup188 TAIL domain
分子名称: GLYCEROL, Nucleoporin NUP188
著者Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A.
登録日2015-07-28
公開日2015-09-16
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
2I5Z
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BU of 2i5z by Molmil
The crystal structure of OspA mutant
分子名称: Outer surface protein A, TETRAETHYLENE GLYCOL
著者Makabe, K, Terechko, V, Koide, S.
登録日2006-08-26
公開日2007-07-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Hydrophobic surface burial is the major stability determinant of a flat, single-layer beta-sheet.
J.Mol.Biol., 368, 2007
7TVJ
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BU of 7tvj by Molmil
Crystal Structure of Monobody Mb(SHP2PTP_13)/SHP2 PTP Domain Complex
分子名称: CITRATE ANION, Mb(SHP2PTP_13), Tyrosine-protein phosphatase non-receptor type 11
著者Sha, F, Koide, S.
登録日2022-02-05
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation.
J.Mol.Biol., 435, 2023
5A40
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BU of 5a40 by Molmil
Crystal structure of a dual topology fluoride ion channel.
分子名称: MERCURY (II) ION, MONOBODIES, PUTATIVE FLUORIDE ION TRANSPORTER CRCB
著者Stockbridge, R.B, Kolmakova-Partensky, L, Shane, T, Koide, A, Koide, S, Miller, C, Newstead, S.
登録日2015-06-04
公開日2015-09-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Crystal Structures of a Double-Barrelled Fluoride Ion Channel.
Nature, 525, 2015
8EZG
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BU of 8ezg by Molmil
Monobody 12D1 bound to KRAS(G12D)
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Hattori, T, Glasser, E, Akkapeddi, P, Ketavarapu, G, Teng, K.W, Koide, A, Koide, S.
登録日2022-10-31
公開日2023-07-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F0M
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BU of 8f0m by Molmil
Monobody 12D5 bound to KRAS(G12D)
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ...
著者Hattori, T, Glasser, E, Akkapeddi, P, Ketavarapu, G, Teng, K.W, Koide, A, Koide, S.
登録日2022-11-03
公開日2023-07-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Proc.Natl.Acad.Sci.USA, 120, 2023
5A43
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BU of 5a43 by Molmil
Crystal structure of a dual topology fluoride ion channel.
分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, FLUORIDE ION, MONOBODIES, ...
著者Stockbridge, R.B, Kolmakova-Partensky, L, Shane, T, Koide, A, Koide, S, Miller, C, Newstead, S.
登録日2015-06-04
公開日2015-09-02
最終更新日2015-09-30
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Crystal Structures of a Double-Barrelled Fluoride Ion Channel.
Nature, 525, 2015
5VG9
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BU of 5vg9 by Molmil
Structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase) without a monobody
分子名称: Protein-S-isoprenylcysteine O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Long, S.B, Diver, M.M, Pedi, L, Koide, A, Koide, S.
登録日2017-04-10
公開日2018-01-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
Nature, 553, 2018
5DC4
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BU of 5dc4 by Molmil
CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A
分子名称: AS25 monobody, GLYCEROL, Tyrosine-protein kinase ABL1
著者Wojcik, J.B, Koide, A, Koide, S.
登録日2015-08-23
公開日2016-03-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.
J.Biol.Chem., 291, 2016
5DC9
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BU of 5dc9 by Molmil
CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL B
分子名称: AS25 monobody, GLYCEROL, IMIDAZOLE, ...
著者Wojcik, J.B, Koide, A, Koide, S.
登録日2015-08-23
公開日2016-03-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.
J.Biol.Chem., 291, 2016
3EFF
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BU of 3eff by Molmil
The Crystal Structure of Full-Length KcsA in its Closed Conformation
分子名称: FAB, Voltage-gated potassium channel
著者Uysal, S, Vasquez, V, Tereshko, T, Esaki, K, Fellouse, F.A, Sidhu, S.S, Koide, S, Perozo, E, Kossiakoff, A.
登録日2008-09-08
公開日2009-04-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal structure of full-length KcsA in its closed conformation.
Proc.Natl.Acad.Sci.USA, 106, 2009
7SFX
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BU of 7sfx by Molmil
10A1 Fab in complex with CD99 peptide
分子名称: 10A1 Fab heavy chain, 10A1 Fab light chain, CD99 antigen peptide
著者Romero, L.A, Hattori, T, Koide, S.
登録日2021-10-04
公開日2021-12-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献High-valency Anti-CD99 Antibodies Toward the Treatment of T Cell Acute Lymphoblastic Leukemia.
J.Mol.Biol., 434, 2021
6D0N
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BU of 6d0n by Molmil
Crystal structure of a CLC-type fluoride/proton antiporter, V319G mutant
分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C.
登録日2018-04-10
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献A CLC-type F-/H+antiporter in ion-swapped conformations.
Nat. Struct. Mol. Biol., 25, 2018
6D0K
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BU of 6d0k by Molmil
Crystal structure of a CLC-type fluoride/proton antiporter, E118Q mutant
分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C.
登録日2018-04-10
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献A CLC-type F-/H+antiporter in ion-swapped conformations.
Nat. Struct. Mol. Biol., 25, 2018
6D0J
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BU of 6d0j by Molmil
Crystal structure of a CLC-type fluoride/proton antiporter
分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C.
登録日2018-04-10
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A CLC-type F-/H+antiporter in ion-swapped conformations.
Nat. Struct. Mol. Biol., 25, 2018
2OCF
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BU of 2ocf by Molmil
Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody
分子名称: ESTRADIOL, Estrogen receptor, Fibronectin
著者Rajan, S.S, Kuruvilla, S.M, Sharma, S.K, Kim, Y, Huang, J, Koide, A, Koide, S, Joachimiak, A, Greene, G.L.
登録日2006-12-20
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor.
Proc.Natl.Acad.Sci.USA, 99, 2002
5G15
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BU of 5g15 by Molmil
Structure Aurora A (122-403) bound to activating monobody Mb1 and AMPPCP
分子名称: AURORA A KINASE, MAGNESIUM ION, MB1 MONOBODY, ...
著者Zorba, A, Kutter, S, Kern, D, Koide, S, Koide, A.
登録日2016-03-23
公開日2018-03-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Allosteric modulation of a human protein kinase with monobodies.
Proc.Natl.Acad.Sci.USA, 116, 2019
2KIR
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BU of 2kir by Molmil
Solution structure of a designer toxin, mokatoxin-1
分子名称: Designer toxin
著者Biancalana, M, Koide, A, Takacs, Z, Goldstein, S, Koide, S.
登録日2009-05-07
公開日2009-12-29
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Proc.Natl.Acad.Sci.USA, 106, 2009

 

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