6CPG

Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation

Summary for 6CPG

Entry DOI	10.2210/pdb6cpg/pdb
Descriptor	Aurora kinase A, Monobody, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea (3 entities in total)
Functional Keywords	protein kinase, dfg-loop, monobody, at9283, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	86452.35
Authors	Otten, R.,Kutter, S.,Zorba, A.,Padua, R.A.P.,Koide, A.,Koide, S.,Kern, D. (deposition date: 2018-03-13, release date: 2018-06-27, Last modification date: 2023-10-04)
Primary citation	Pitsawong, W.,Buosi, V.,Otten, R.,Agafonov, R.V.,Zorba, A.,Kern, N.,Kutter, S.,Kern, G.,Padua, R.A.,Meniche, X.,Kern, D. Dynamics of human protein kinase Aurora A linked to drug selectivity. Elife, 7:-, 2018 Cited by PubMed: 29901437 DOI: 10.7554/eLife.36656 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation