6CPG
Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | Aurora kinase A | polymer | 285 | 32990.8 | 2 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | B, D (B, E) | Monobody | polymer | 93 | 9854.0 | 2 | synthetic construct | ||
| 3 | E, F (A, D) | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea | non-polymer | 381.4 | 2 | Chemie (35R) |
Sequence modifications
A, D: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ser 119 | - | expression tag |
| Val 120 | - | expression tag |
| Asp 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 85689.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 762.9 | |
| All* | Total formula weight | 86452.3 |
