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PDB: 49 件
5V7P
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BU of 5v7p by Molmil
Atomic structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase), in complex with a monobody
分子名称: DECANE, Protein-S-isoprenylcysteine O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Long, S.B, Diver, M.M, Pedi, L, Koide, A, Koide, S.
登録日2017-03-20
公開日2018-01-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
Nature, 553, 2018
4IOF
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BU of 4iof by Molmil
Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)
分子名称: Fab-bound IDE, heavy chain, light chain, ...
著者McCord, L.A, Liang, W.G, Hoey, R, Dowdell, E, Koide, A, Koide, S, Tang, W.J.
登録日2013-01-07
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.353 Å)
主引用文献Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
Proc.Natl.Acad.Sci.USA, 110, 2013
6CPG
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BU of 6cpg by Molmil
Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation
分子名称: 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea, Aurora kinase A, Monobody
著者Otten, R, Kutter, S, Zorba, A, Padua, R.A.P, Koide, A, Koide, S, Kern, D.
登録日2018-03-13
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Dynamics of human protein kinase Aurora A linked to drug selectivity.
Elife, 7, 2018
2AF5
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BU of 2af5 by Molmil
2.5A X-ray Structure of Engineered OspA protein
分子名称: Engineered Outer Surface Protein A (OspA) with the inserted two beta-hairpins
著者Makabe, K, Mcelheny, D, Tereshko, V, Hilyard, A, Koide, A, Koide, S.
登録日2005-07-25
公開日2006-08-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Atomic structures of peptide self-assembly mimics.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5CWW
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BU of 5cww by Molmil
Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complex
分子名称: Nucleoporin NUP145N, Nucleoporin NUP159, Nucleoporin NUP82
著者Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A.
登録日2015-07-28
公開日2015-09-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
5CWV
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BU of 5cwv by Molmil
Crystal structure of Chaetomium thermophilum Nup192 TAIL domain
分子名称: Nucleoporin NUP192
著者Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A.
登録日2015-07-28
公開日2015-09-16
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3.155 Å)
主引用文献Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
5CWU
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BU of 5cwu by Molmil
Crystal structure of Chaetomium thermophilum Nup188 TAIL domain
分子名称: GLYCEROL, Nucleoporin NUP188
著者Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A.
登録日2015-07-28
公開日2015-09-16
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Architecture of the fungal nuclear pore inner ring complex.
Science, 350, 2015
8EZG
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BU of 8ezg by Molmil
Monobody 12D1 bound to KRAS(G12D)
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Hattori, T, Glasser, E, Akkapeddi, P, Ketavarapu, G, Teng, K.W, Koide, A, Koide, S.
登録日2022-10-31
公開日2023-07-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F0M
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Monobody 12D5 bound to KRAS(G12D)
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ...
著者Hattori, T, Glasser, E, Akkapeddi, P, Ketavarapu, G, Teng, K.W, Koide, A, Koide, S.
登録日2022-11-03
公開日2023-07-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Proc.Natl.Acad.Sci.USA, 120, 2023
5VG9
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BU of 5vg9 by Molmil
Structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase) without a monobody
分子名称: Protein-S-isoprenylcysteine O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Long, S.B, Diver, M.M, Pedi, L, Koide, A, Koide, S.
登録日2017-04-10
公開日2018-01-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
Nature, 553, 2018
5DC4
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BU of 5dc4 by Molmil
CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A
分子名称: AS25 monobody, GLYCEROL, Tyrosine-protein kinase ABL1
著者Wojcik, J.B, Koide, A, Koide, S.
登録日2015-08-23
公開日2016-03-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.
J.Biol.Chem., 291, 2016
5DC9
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BU of 5dc9 by Molmil
CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL B
分子名称: AS25 monobody, GLYCEROL, IMIDAZOLE, ...
著者Wojcik, J.B, Koide, A, Koide, S.
登録日2015-08-23
公開日2016-03-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.
J.Biol.Chem., 291, 2016
5A40
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BU of 5a40 by Molmil
Crystal structure of a dual topology fluoride ion channel.
分子名称: MERCURY (II) ION, MONOBODIES, PUTATIVE FLUORIDE ION TRANSPORTER CRCB
著者Stockbridge, R.B, Kolmakova-Partensky, L, Shane, T, Koide, A, Koide, S, Miller, C, Newstead, S.
登録日2015-06-04
公開日2015-09-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Crystal Structures of a Double-Barrelled Fluoride Ion Channel.
Nature, 525, 2015
5A43
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BU of 5a43 by Molmil
Crystal structure of a dual topology fluoride ion channel.
分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, FLUORIDE ION, MONOBODIES, ...
著者Stockbridge, R.B, Kolmakova-Partensky, L, Shane, T, Koide, A, Koide, S, Miller, C, Newstead, S.
登録日2015-06-04
公開日2015-09-02
最終更新日2015-09-30
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Crystal Structures of a Double-Barrelled Fluoride Ion Channel.
Nature, 525, 2015
5G15
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BU of 5g15 by Molmil
Structure Aurora A (122-403) bound to activating monobody Mb1 and AMPPCP
分子名称: AURORA A KINASE, MAGNESIUM ION, MB1 MONOBODY, ...
著者Zorba, A, Kutter, S, Kern, D, Koide, S, Koide, A.
登録日2016-03-23
公開日2018-03-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Allosteric modulation of a human protein kinase with monobodies.
Proc.Natl.Acad.Sci.USA, 116, 2019
5E95
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BU of 5e95 by Molmil
Crystal Structure of Mb(NS1)/H-Ras Complex
分子名称: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Eguchi, R.R, Sha, F, Gupta, A, Koide, A, Koide, S.
登録日2015-10-14
公開日2016-11-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.402 Å)
主引用文献Inhibition of RAS function through targeting an allosteric regulatory site.
Nat. Chem. Biol., 13, 2017
2KIR
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BU of 2kir by Molmil
Solution structure of a designer toxin, mokatoxin-1
分子名称: Designer toxin
著者Biancalana, M, Koide, A, Takacs, Z, Goldstein, S, Koide, S.
登録日2009-05-07
公開日2009-12-29
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Proc.Natl.Acad.Sci.USA, 106, 2009
2OCF
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BU of 2ocf by Molmil
Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody
分子名称: ESTRADIOL, Estrogen receptor, Fibronectin
著者Rajan, S.S, Kuruvilla, S.M, Sharma, S.K, Kim, Y, Huang, J, Koide, A, Koide, S, Joachimiak, A, Greene, G.L.
登録日2006-12-20
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor.
Proc.Natl.Acad.Sci.USA, 99, 2002
6D0N
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BU of 6d0n by Molmil
Crystal structure of a CLC-type fluoride/proton antiporter, V319G mutant
分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C.
登録日2018-04-10
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献A CLC-type F-/H+antiporter in ion-swapped conformations.
Nat. Struct. Mol. Biol., 25, 2018
6D0K
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Crystal structure of a CLC-type fluoride/proton antiporter, E118Q mutant
分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C.
登録日2018-04-10
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献A CLC-type F-/H+antiporter in ion-swapped conformations.
Nat. Struct. Mol. Biol., 25, 2018
6D0J
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Crystal structure of a CLC-type fluoride/proton antiporter
分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C.
登録日2018-04-10
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A CLC-type F-/H+antiporter in ion-swapped conformations.
Nat. Struct. Mol. Biol., 25, 2018
7LO8
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BU of 7lo8 by Molmil
NorA in complex with Fab36
分子名称: Fab36 Heavy Chain, Fab36 Light Chain, Quinolone resistance protein NorA
著者Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N.
登録日2021-02-09
公開日2022-04-20
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
7LO7
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BU of 7lo7 by Molmil
NorA in complex with Fab25
分子名称: Fab25 Heavy Chain, Fab25 Light Chain, Quinolone resistance protein NorA
著者Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N.
登録日2021-02-09
公開日2022-04-20
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.74 Å)
主引用文献Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
3UYO
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BU of 3uyo by Molmil
Crystal structure of monobody SH13/ABL1 SH2 domain complex
分子名称: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1
著者Wojcik, J.B, Koide, A, Koide, S.
登録日2011-12-06
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold.
J.Mol.Biol., 415, 2012
2Z8G
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Aspergillus niger ATCC9642 isopullulanase complexed with isopanose
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isopullulanase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-6)-beta-D-glucopyranose
著者Mizuno, M, Koide, A, Yamamura, A, Akeboshi, H, Yoshida, H, Kamitori, S, Sakano, Y, Nishikawa, A, Tonozuka, T.
登録日2007-09-05
公開日2007-12-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Aspergillus niger Isopullulanase, a Member of Glycoside Hydrolase Family 49
J.Mol.Biol., 376, 2008

 

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