2AQB
 
 | | Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli | | 分子名称: | (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | | 著者 | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | | 登録日 | 2005-08-17 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
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2AQ7
 | | Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli | | 分子名称: | (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | | 著者 | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | | 登録日 | 2005-08-17 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
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1Q68
 | | Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments | | 分子名称: | Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD4, ZINC ION | | 著者 | Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J. | | 登録日 | 2003-08-12 | | 公開日 | 2003-11-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science, 301, 2003
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1Q69
 | | Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments | | 分子名称: | Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD8 alpha chain, ZINC ION | | 著者 | Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J. | | 登録日 | 2003-08-12 | | 公開日 | 2003-11-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science, 301, 2003
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2C0Z
 | | The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides | | 分子名称: | 1,2-ETHANEDIOL, NOVW, SULFATE ION | | 著者 | Jakimowicz, P, Tello, M, Freel-Meyers, C.L, Walsh, C.T, Buttner, M.J, Field, R.A, Lawson, D.M. | | 登録日 | 2005-09-09 | | 公開日 | 2006-01-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides
Proteins, 63, 2006
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1AJJ
 | | LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING | | 分子名称: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, SULFATE ION | | 著者 | Fass, D, Blacklow, S.C, Kim, P.S, Berger, J.M. | | 登録日 | 1997-05-04 | | 公開日 | 1997-07-07 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.
Nature, 388, 1997
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1TGG
 | | RH3 DESIGNED RIGHT-HANDED COILED COIL TRIMER | | 分子名称: | CHLORIDE ION, NICKEL (II) ION, right-handed coiled coil trimer | | 著者 | Plecs, J.J, Harbury, P.B, Kim, P.S, Alber, T. | | 登録日 | 2004-05-28 | | 公開日 | 2004-10-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural test of the parameterized-backbone method for protein design
J.Mol.Biol., 342, 2004
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1K1F
 | | Structure of the Bcr-Abl Oncoprotein Oligomerization domain | | 分子名称: | BREAKPOINT CLUSTER REGION PROTEIN | | 著者 | Zhao, X, Ghaffari, S, Lodish, H, Malashkevich, V.N, Kim, P.S. | | 登録日 | 2001-09-25 | | 公開日 | 2002-02-06 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the Bcr-Abl oncoprotein oligomerization domain.
Nat.Struct.Biol., 9, 2002
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2ZTA
 | | X-RAY STRUCTURE OF THE GCN4 LEUCINE ZIPPER, A TWO-STRANDED, PARALLEL COILED COIL | | 分子名称: | GCN4 LEUCINE ZIPPER | | 著者 | O'Shea, E.K, Klemm, J.D, Kim, P.S, Alber, T. | | 登録日 | 1991-07-05 | | 公開日 | 1992-10-15 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.
Science, 254, 1991
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1GCM
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2Q5U
 | | Crystal structure of IQN17 | | 分子名称: | CHLORIDE ION, Fusion protein between yeast variant GCN4 and HIVgp41 | | 著者 | Malashkevich, V.N, Eckert, D.M, Hong, L.H, Kim, P.S. | | 登録日 | 2007-06-01 | | 公開日 | 2007-06-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Inhibiting HIV Entry: Discovery of D-Peptide Inhibitors that Target the Gp41 Coiled-Coil Pocket
Cell(Cambridge,Mass.), 99, 1999
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2Q3I
 | | Crystal structure of the D10-P3/IQN17 complex: a D-peptide inhibitor of HIV-1 entry bound to the GP41 coiled-coil pocket | | 分子名称: | CHLORIDE ION, D-peptide, Fusion protein between the Coiled-Coil pocket of HIV GP41 and gcn4-PIQI | | 著者 | Malashkevich, V.N, Eckert, D.M, Hong, L.H, Carr, P.A, Kim, P.S. | | 登録日 | 2007-05-30 | | 公開日 | 2007-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Inhibiting HIV Entry: Discovery of D-Peptide Inhibitors that Target the Gp41 Coiled-Coil Pocket
Cell(Cambridge,Mass.), 99, 1999
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2Q7C
 | | Crystal structure of IQN17 | | 分子名称: | CHLORIDE ION, fusion protein between yeast variant GCN4 and HIVgp41 | | 著者 | Malashkevich, V.N, Eckert, D.M, Hong, L.H, Kim, P.S. | | 登録日 | 2007-06-06 | | 公開日 | 2007-06-19 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Inhibiting HIV Entry: Discovery of D-Peptide Inhibitors that Target the Gp41 Coiled-Coil Pocket
Cell(Cambridge,Mass.), 99, 1999
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6UMV
 | | Human apo PD-1 double mutant | | 分子名称: | CHLORIDE ION, Programmed cell death protein 1 | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2019-10-10 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.424 Å) | | 主引用文献 | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6UMT
 | | High-affinity human PD-1 PD-L2 complex | | 分子名称: | MAGNESIUM ION, Programmed cell death 1 ligand 2, Programmed cell death protein 1 | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2019-10-10 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.986 Å) | | 主引用文献 | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
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1GCL
 | | GCN4 LEUCINE ZIPPER CORE MUTANT P-LI | | 分子名称: | GCN4 | | 著者 | Harbury, P.B, Zhang, T, Kim, P.S, Alber, T. | | 登録日 | 1993-10-20 | | 公開日 | 1995-06-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants.
Science, 262, 1993
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6UMU
 | | Human apo PD-1 triple mutant | | 分子名称: | CHLORIDE ION, Programmed cell death protein 1 | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2019-10-10 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.183 Å) | | 主引用文献 | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8F3B
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1IJ1
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8F3A
 | | HIV-1 gp41 coiled-coil pocket IQN17 | | 分子名称: | ACETIC ACID, CHLORIDE ION, IQN17 | | 著者 | Bruun, T.U.J, Tang, S, Fernandez, D, Kim, P.S. | | 登録日 | 2022-11-09 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies.
J.Biol.Chem., 299, 2023
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1JEK
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2EBO
 | | CORE STRUCTURE OF GP2 FROM EBOLA VIRUS | | 分子名称: | CHLORIDE ION, EBOLA VIRUS ENVELOPE GLYCOPROTEIN | | 著者 | Malashkevich, V.N, Schneider, B.J, Mcnally, M.L, Milhollen, M.A, Pang, J.X, Kim, P.S. | | 登録日 | 1998-12-24 | | 公開日 | 1999-05-18 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution.
Proc.Natl.Acad.Sci.USA, 96, 1999
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7UX0
 | | Human Sperm TMEM95 Ectodomain | | 分子名称: | Sperm-egg fusion protein TMEM95, TRIETHYLENE GLYCOL, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2022-05-04 | | 公開日 | 2022-10-12 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Human sperm TMEM95 binds eggs and facilitates membrane fusion.
Proc.Natl.Acad.Sci.USA, 119, 2022
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2SIV
 | | SIV GP41 CORE STRUCTURE | | 分子名称: | SIV GP41 GLYCOPROTEIN | | 著者 | Malashkevich, V.N, Chan, D.C, Chutkowski, C.T, Kim, P.S. | | 登録日 | 1998-06-17 | | 公開日 | 1998-08-19 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides.
Proc.Natl.Acad.Sci.USA, 95, 1998
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1CZQ
 | | CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET. | | 分子名称: | CHLORIDE ION, D-PEPTIDE INHIBITOR, FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GCN4-PIQI | | 著者 | Eckert, D.M, Malashkevich, V.N, Hong, L.H, Carr, P.A, Kim, P.S. | | 登録日 | 1999-09-06 | | 公開日 | 1999-10-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.
Cell(Cambridge,Mass.), 99, 1999
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