2Q3I

Crystal structure of the D10-P3/IQN17 complex: a D-peptide inhibitor of HIV-1 entry bound to the GP41 coiled-coil pocket

Summary for 2Q3I

• Entry DOI: 10.2210/pdb2q3i/pdb
• Related: 1CZQ
• Descriptor: Fusion protein between the Coiled-Coil pocket of HIV GP41 and gcn4-PIQI, D-peptide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: envelope glycoprotein, viral protein-inhibitor complex, viral protein/inhibitor
• Total number of polymer chains: 2
• Total formula weight: 7271.01

Authors

Malashkevich, V.N.,Eckert, D.M.,Hong, L.H.,Carr, P.A.,Kim, P.S. (deposition date: 2007-05-30, release date: 2007-06-12, Last modification date: 2023-11-15)

• Primary citation: Eckert, D.M.,Malashkevich, V.N.,Hong, L.H.,Carr, P.A.,Kim, P.S.; Inhibiting HIV Entry: Discovery of D-Peptide Inhibitors that Target the Gp41 Coiled-Coil Pocket; Cell(Cambridge,Mass.), 99:103-105, 1999; PubMed: 10520998; DOI: 10.1016/S0092-8674(00)80066-5

Experimental method

X-RAY DIFFRACTION (1.5 Å)