2AQ7
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![BU of 2aq7 by Molmil](/molmil-images/mine/2aq7) | Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli | Descriptor: | (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | Authors: | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | Deposit date: | 2005-08-17 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
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2AQB
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![BU of 2aqb by Molmil](/molmil-images/mine/2aqb) | Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli | Descriptor: | (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | Authors: | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | Deposit date: | 2005-08-17 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
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1Q69
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![BU of 1q69 by Molmil](/molmil-images/mine/1q69) | Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments | Descriptor: | Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD8 alpha chain, ZINC ION | Authors: | Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J. | Deposit date: | 2003-08-12 | Release date: | 2003-11-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science, 301, 2003
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1Q68
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![BU of 1q68 by Molmil](/molmil-images/mine/1q68) | Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments | Descriptor: | Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD4, ZINC ION | Authors: | Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J. | Deposit date: | 2003-08-12 | Release date: | 2003-11-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science, 301, 2003
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2C0Z
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![BU of 2c0z by Molmil](/molmil-images/mine/2c0z) | The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides | Descriptor: | 1,2-ETHANEDIOL, NOVW, SULFATE ION | Authors: | Jakimowicz, P, Tello, M, Freel-Meyers, C.L, Walsh, C.T, Buttner, M.J, Field, R.A, Lawson, D.M. | Deposit date: | 2005-09-09 | Release date: | 2006-01-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides Proteins, 63, 2006
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1IJ1
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![BU of 1ij1 by Molmil](/molmil-images/mine/1ij1) | |
1IJ2
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![BU of 1ij2 by Molmil](/molmil-images/mine/1ij2) | |
1IJ0
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![BU of 1ij0 by Molmil](/molmil-images/mine/1ij0) | |
2SIV
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![BU of 2siv by Molmil](/molmil-images/mine/2siv) | SIV GP41 CORE STRUCTURE | Descriptor: | SIV GP41 GLYCOPROTEIN | Authors: | Malashkevich, V.N, Chan, D.C, Chutkowski, C.T, Kim, P.S. | Deposit date: | 1998-06-17 | Release date: | 1998-08-19 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides. Proc.Natl.Acad.Sci.USA, 95, 1998
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8F3B
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![BU of 8f3b by Molmil](/molmil-images/mine/8f3b) | |
1GCM
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![BU of 1gcm by Molmil](/molmil-images/mine/1gcm) | |
8F3A
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![BU of 8f3a by Molmil](/molmil-images/mine/8f3a) | HIV-1 gp41 coiled-coil pocket IQN17 | Descriptor: | ACETIC ACID, CHLORIDE ION, IQN17 | Authors: | Bruun, T.U.J, Tang, S, Fernandez, D, Kim, P.S. | Deposit date: | 2022-11-09 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies. J.Biol.Chem., 299, 2023
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2EBO
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![BU of 2ebo by Molmil](/molmil-images/mine/2ebo) | CORE STRUCTURE OF GP2 FROM EBOLA VIRUS | Descriptor: | CHLORIDE ION, EBOLA VIRUS ENVELOPE GLYCOPROTEIN | Authors: | Malashkevich, V.N, Schneider, B.J, Mcnally, M.L, Milhollen, M.A, Pang, J.X, Kim, P.S. | Deposit date: | 1998-12-24 | Release date: | 1999-05-18 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc.Natl.Acad.Sci.USA, 96, 1999
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1TGG
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![BU of 1tgg by Molmil](/molmil-images/mine/1tgg) | RH3 DESIGNED RIGHT-HANDED COILED COIL TRIMER | Descriptor: | CHLORIDE ION, NICKEL (II) ION, right-handed coiled coil trimer | Authors: | Plecs, J.J, Harbury, P.B, Kim, P.S, Alber, T. | Deposit date: | 2004-05-28 | Release date: | 2004-10-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural test of the parameterized-backbone method for protein design J.Mol.Biol., 342, 2004
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1JEK
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![BU of 1jek by Molmil](/molmil-images/mine/1jek) | Visna TM CORE STRUCTURE | Descriptor: | ENV POLYPROTEIN | Authors: | Malashkevich, V.N, Singh, M, Kim, P.S. | Deposit date: | 2001-06-18 | Release date: | 2001-07-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The trimer-of-hairpins motif in membrane fusion: Visna virus. Proc.Natl.Acad.Sci.USA, 98, 2001
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1GCL
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![BU of 1gcl by Molmil](/molmil-images/mine/1gcl) | GCN4 LEUCINE ZIPPER CORE MUTANT P-LI | Descriptor: | GCN4 | Authors: | Harbury, P.B, Zhang, T, Kim, P.S, Alber, T. | Deposit date: | 1993-10-20 | Release date: | 1995-06-03 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science, 262, 1993
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2ZTA
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![BU of 2zta by Molmil](/molmil-images/mine/2zta) | X-RAY STRUCTURE OF THE GCN4 LEUCINE ZIPPER, A TWO-STRANDED, PARALLEL COILED COIL | Descriptor: | GCN4 LEUCINE ZIPPER | Authors: | O'Shea, E.K, Klemm, J.D, Kim, P.S, Alber, T. | Deposit date: | 1991-07-05 | Release date: | 1992-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science, 254, 1991
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2Q7C
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![BU of 2q7c by Molmil](/molmil-images/mine/2q7c) | Crystal structure of IQN17 | Descriptor: | CHLORIDE ION, fusion protein between yeast variant GCN4 and HIVgp41 | Authors: | Malashkevich, V.N, Eckert, D.M, Hong, L.H, Kim, P.S. | Deposit date: | 2007-06-06 | Release date: | 2007-06-19 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Inhibiting HIV Entry: Discovery of D-Peptide Inhibitors that Target the Gp41 Coiled-Coil Pocket Cell(Cambridge,Mass.), 99, 1999
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2Q3I
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![BU of 2q3i by Molmil](/molmil-images/mine/2q3i) | Crystal structure of the D10-P3/IQN17 complex: a D-peptide inhibitor of HIV-1 entry bound to the GP41 coiled-coil pocket | Descriptor: | CHLORIDE ION, D-peptide, Fusion protein between the Coiled-Coil pocket of HIV GP41 and gcn4-PIQI | Authors: | Malashkevich, V.N, Eckert, D.M, Hong, L.H, Carr, P.A, Kim, P.S. | Deposit date: | 2007-05-30 | Release date: | 2007-06-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Inhibiting HIV Entry: Discovery of D-Peptide Inhibitors that Target the Gp41 Coiled-Coil Pocket Cell(Cambridge,Mass.), 99, 1999
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6UMV
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![BU of 6umv by Molmil](/molmil-images/mine/6umv) | Human apo PD-1 double mutant | Descriptor: | CHLORIDE ION, Programmed cell death protein 1 | Authors: | Tang, S, Kim, P.S. | Deposit date: | 2019-10-10 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.424 Å) | Cite: | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc.Natl.Acad.Sci.USA, 116, 2019
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6UMT
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![BU of 6umt by Molmil](/molmil-images/mine/6umt) | High-affinity human PD-1 PD-L2 complex | Descriptor: | MAGNESIUM ION, Programmed cell death 1 ligand 2, Programmed cell death protein 1 | Authors: | Tang, S, Kim, P.S. | Deposit date: | 2019-10-10 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.986 Å) | Cite: | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc.Natl.Acad.Sci.USA, 116, 2019
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6UMU
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![BU of 6umu by Molmil](/molmil-images/mine/6umu) | Human apo PD-1 triple mutant | Descriptor: | CHLORIDE ION, Programmed cell death protein 1 | Authors: | Tang, S, Kim, P.S. | Deposit date: | 2019-10-10 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.183 Å) | Cite: | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc.Natl.Acad.Sci.USA, 116, 2019
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1RH4
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![BU of 1rh4 by Molmil](/molmil-images/mine/1rh4) | RH4 DESIGNED RIGHT-HANDED COILED COIL TETRAMER | Descriptor: | ISOPROPYL ALCOHOL, RIGHT-HANDED COILED COIL TETRAMER | Authors: | Harbury, P.B, Plecs, J.J, Tidor, B, Alber, T, Kim, P.S. | Deposit date: | 1998-10-07 | Release date: | 1998-12-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High-resolution protein design with backbone freedom. Science, 282, 1998
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2Q5U
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![BU of 2q5u by Molmil](/molmil-images/mine/2q5u) | Crystal structure of IQN17 | Descriptor: | CHLORIDE ION, Fusion protein between yeast variant GCN4 and HIVgp41 | Authors: | Malashkevich, V.N, Eckert, D.M, Hong, L.H, Kim, P.S. | Deposit date: | 2007-06-01 | Release date: | 2007-06-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Inhibiting HIV Entry: Discovery of D-Peptide Inhibitors that Target the Gp41 Coiled-Coil Pocket Cell(Cambridge,Mass.), 99, 1999
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1AJJ
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![BU of 1ajj by Molmil](/molmil-images/mine/1ajj) | LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, SULFATE ION | Authors: | Fass, D, Blacklow, S.C, Kim, P.S, Berger, J.M. | Deposit date: | 1997-05-04 | Release date: | 1997-07-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature, 388, 1997
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