6YJ2
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![BU of 6yj2 by Molmil](/molmil-images/mine/6yj2) | Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism | Descriptor: | GLYCEROL, Probable transcriptional regulatory protein (Probably TetR-family) | Authors: | Keep, N.H, Pritchard, J.E, Sula, A, Cole, A.R, Kendall, S.L. | Deposit date: | 2020-04-02 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism To be published
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6YL2
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![BU of 6yl2 by Molmil](/molmil-images/mine/6yl2) | Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism | Descriptor: | DNA (5'-D(*AP*CP*GP*TP*TP*AP*AP*TP*GP*AP*CP*GP*AP*TP*TP*AP*AP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*TP*TP*AP*AP*TP*CP*GP*TP*CP*AP*TP*TP*AP*AP*CP*GP*T)-3'), Probable transcriptional regulatory protein (Probably TetR-family) | Authors: | Keep, N.H, Pritchard, J.E, Sula, A, Cole, A.R, Kendall, S.L. | Deposit date: | 2020-04-06 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism To be published
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6RP3
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![BU of 6rp3 by Molmil](/molmil-images/mine/6rp3) | Truncated Norcoclaurine synthase with reaction intermediate mimic | Descriptor: | 1,2-ETHANEDIOL, 4-[2-[[(2~{R})-2-phenylpropyl]amino]ethyl]benzene-1,2-diol, S-norcoclaurine synthase | Authors: | Keep, N.H, Roddan, R, Sula, A. | Deposit date: | 2019-05-13 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Acceptance and Kinetic Resolution of alpha-Methyl-Substituted Aldehydes by Norcoclaurine Synthases Acs Catalysis, 2019
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1BHD
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![BU of 1bhd by Molmil](/molmil-images/mine/1bhd) | |
1QAG
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![BU of 1qag by Molmil](/molmil-images/mine/1qag) | Actin binding region of the dystrophin homologue utrophin | Descriptor: | UTROPHIN ACTIN BINDING REGION | Authors: | Keep, N.H, Winder, S.J, Moores, C.A, Walke, S, Norwood, F.L.M, Kendrick-Jones, J. | Deposit date: | 1999-03-05 | Release date: | 2000-01-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer Structure Fold.Des., 7, 1999
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1RHO
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![BU of 1rho by Molmil](/molmil-images/mine/1rho) | STRUCTURE OF RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR | Descriptor: | RHO GDP-DISSOCIATION INHIBITOR 1, SULFATE ION | Authors: | Keep, N.H, Moody, P.C.E, Roberts, G.C.K. | Deposit date: | 1996-10-12 | Release date: | 1997-10-15 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure, 5, 1997
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4WJT
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![BU of 4wjt by Molmil](/molmil-images/mine/4wjt) | Stationary Phase Survival Protein YuiC from B.subtilis complexed with NAG | Descriptor: | (2S)-2-{[(2S)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | Authors: | Quay, D.H.X, Cole, A.R, Cryar, A, Thalassinos, K, Williams, M.A, Bhakta, S, Keep, N.H. | Deposit date: | 2014-10-01 | Release date: | 2015-07-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Structure of the stationary phase survival protein YuiC from B.subtilis. Bmc Struct.Biol., 15, 2015
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2YMV
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![BU of 2ymv by Molmil](/molmil-images/mine/2ymv) | Structure of Reduced M Smegmatis 5246, a homologue of M.Tuberculosis Acg | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, ACG NITROREDUCTASE, ... | Authors: | Chauviac, F.-X, Bommer, M, Dobbek, H, Keep, N.H. | Deposit date: | 2012-10-10 | Release date: | 2012-11-21 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of Reduced Msacg, a Putative Nitroreductase from Mycobacterium Smegmatis and a Close Homologue of Mycobacterium Tuberculosis Acg. J.Biol.Chem., 287, 2012
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6Z82
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6F2R
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![BU of 6f2r by Molmil](/molmil-images/mine/6f2r) | A heterotetramer of human HspB2 and HspB3 | Descriptor: | Heat shock protein beta-2, Heat shock protein beta-3,Heat shock protein beta-3,Heat shock protein beta-3,Heat shock protein beta-3,Heat shock protein beta-2, HspB2,Heat shock protein beta-2,Heat shock protein beta-2,Heat shock protein beta-2,Heat shock protein beta-2,Heat shock protein beta-2, ... | Authors: | Clark, A.R, Cole, A.R, Boelens, W.C, Keep, N.H, Slingsby, C. | Deposit date: | 2017-11-27 | Release date: | 2018-07-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Terminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3. J.Mol.Biol., 430, 2018
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4WLK
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![BU of 4wlk by Molmil](/molmil-images/mine/4wlk) | Stationary Phase Survival Protein YuiC from B.subtilis complexed with reaction product | Descriptor: | N-[(1R,2S,3R,4R,5R)-2-[(2S,3R,4R,5S,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-6,8-dioxabicyclo[3.2.1]octan-4-yl]ethanamide, YuiC | Authors: | Quay, D.H.X, Cole, A.R, Cryar, A, Thalassinos, K, Williams, M.A, Bhakta, S, Keep, N.H. | Deposit date: | 2014-10-07 | Release date: | 2015-07-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structure of the stationary phase survival protein YuiC from B.subtilis. Bmc Struct.Biol., 15, 2015
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4Z39
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![BU of 4z39 by Molmil](/molmil-images/mine/4z39) | Structure of OBP3 from the vetch aphid Megoura viciae | Descriptor: | GLYCEROL, Odorant-binding protein, SULFATE ION | Authors: | Northey, T, Venthur, H, De Biasio, F, Chauviac, F.-X, Cole, A.R, Field, L.M, Zhou, J.-J, Keep, N.H. | Deposit date: | 2015-03-31 | Release date: | 2016-04-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal Structures and Binding Dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri. Sci Rep, 6, 2016
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4Z45
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![BU of 4z45 by Molmil](/molmil-images/mine/4z45) | Structure of OBP3 from the currant-lettuce aphid Nasonovia ribisnigri | Descriptor: | Odorant-binding protein NribOBP3 | Authors: | Northey, T, Venthur, H, De Biasio, F, Chauviac, F.-X, Cole, A.R, Field, L.M, Zhou, J.-J, Keep, N.H. | Deposit date: | 2015-04-01 | Release date: | 2016-04-13 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Crystal Structures and Binding Dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri. Sci Rep, 6, 2016
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4WLI
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![BU of 4wli by Molmil](/molmil-images/mine/4wli) | Stationary Phase Survival Protein YuiC from B.subtilis | Descriptor: | 1,2-ETHANEDIOL, YuiC | Authors: | Quay, D.H.X, Cole, A.R, Cryar, A, Thalassinos, K, Williams, M.A, Bhakta, S, Keep, N.H. | Deposit date: | 2014-10-07 | Release date: | 2015-07-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structure of the stationary phase survival protein YuiC from B.subtilis. Bmc Struct.Biol., 15, 2015
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4OW1
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![BU of 4ow1 by Molmil](/molmil-images/mine/4ow1) | Crystal Structure of Resuscitation Promoting Factor C | Descriptor: | 1,2-ETHANEDIOL, Resuscitation-promoting factor RpfC | Authors: | Chauviac, F.X, Quay, D.H.X, Cohen-Gonsaud, M, Keep, N.H. | Deposit date: | 2014-01-29 | Release date: | 2014-06-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation-promoting factor catalytic domain. Acta Crystallogr.,Sect.F, 70, 2014
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4CAH
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![BU of 4cah by Molmil](/molmil-images/mine/4cah) | Structure of inner DysF domain of human dysferlin | Descriptor: | DYSFERLIN, PHOSPHATE ION | Authors: | Sula, A, Cole, A.R, Yeats, C, Orengo, C, Keep, N.H. | Deposit date: | 2013-10-08 | Release date: | 2014-01-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Crystal Structures of the Human Dysferlin Inner Dysf Domain Bmc Struct.Biol., 14, 2014
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4CAI
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![BU of 4cai by Molmil](/molmil-images/mine/4cai) | Structure of inner DysF domain of human dysferlin | Descriptor: | DYSFERLIN, PHOSPHATE ION | Authors: | Sula, A, Cole, A.R, Yeats, C, Orengo, C, Keep, N.H. | Deposit date: | 2013-10-08 | Release date: | 2014-01-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structures of the Human Dysferlin Inner Dysf Domain Bmc Struct.Biol., 14, 2014
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1XSF
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![BU of 1xsf by Molmil](/molmil-images/mine/1xsf) | Solution structure of a resuscitation promoting factor domain from Mycobacterium tuberculosis | Descriptor: | Probable resuscitation-promoting factor rpfB | Authors: | Cohen-Gonsaud, M, Barthe, P, Henderson, B, Ward, J, Roumestand, C, Keep, N.H. | Deposit date: | 2004-10-19 | Release date: | 2005-02-15 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes Nat.Struct.Mol.Biol., 12, 2005
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5N8Q
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![BU of 5n8q by Molmil](/molmil-images/mine/5n8q) | Structure of truncated Norcoclaurine Synthase from Thalictrum flavum | Descriptor: | S-norcoclaurine synthase | Authors: | Sula, A, Lichman, B.R, Pesnot, T, Ward, J.M, Hailes, H.C, Keep, N.H. | Deposit date: | 2017-02-24 | Release date: | 2017-09-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase. Biochemistry, 56, 2017
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5NON
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![BU of 5non by Molmil](/molmil-images/mine/5non) | Structure of truncated Norcoclaurine Synthase from Thalictrum flavum with product mimic | Descriptor: | 4-[2-[2-(4-methoxyphenyl)ethylamino]ethyl]benzene-1,2-diol, S-norcoclaurine synthase | Authors: | Sula, A, Lichman, B.R, Pesnot, T, Ward, J.M, Hailes, H.C, Keep, N.H. | Deposit date: | 2017-04-12 | Release date: | 2017-09-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase. Biochemistry, 56, 2017
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1E5W
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![BU of 1e5w by Molmil](/molmil-images/mine/1e5w) | |
1GWN
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![BU of 1gwn by Molmil](/molmil-images/mine/1gwn) | The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho-related GTP-binding protein RhoE | Authors: | Garavini, H, Riento, K, Phelan, J.P, McAlister, M.S.B, Ridley, A.J, Keep, N.H. | Deposit date: | 2002-03-19 | Release date: | 2002-04-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of the Core Domain of Rhoe/Rnd3: A Constitutively Activated Small G Protein Biochemistry, 41, 2002
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1GNU
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![BU of 1gnu by Molmil](/molmil-images/mine/1gnu) | GABA(A) receptor associated protein GABARAP | Descriptor: | GABARAP, NICKEL (II) ION | Authors: | Knight, D, Harris, R, Moss, S, Driscoll, P.C, Keep, N.H. | Deposit date: | 2001-10-09 | Release date: | 2001-12-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The X-Ray Crystal Structure and Putative Ligand-Derived Peptide Binding Properties of Gamma-Aminobutyric Acid Receptor Type a Receptor-Associated Protein J.Biol.Chem., 277, 2002
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2K2O
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![BU of 2k2o by Molmil](/molmil-images/mine/2k2o) | |
1DXX
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![BU of 1dxx by Molmil](/molmil-images/mine/1dxx) | |