5NON

Structure of truncated Norcoclaurine Synthase from Thalictrum flavum with product mimic

Summary for 5NON

• Entry DOI: 10.2210/pdb5non/pdb
• Related: 5N8Q
• Descriptor: S-norcoclaurine synthase, 4-[2-[2-(4-methoxyphenyl)ethylamino]ethyl]benzene-1,2-diol (3 entities in total)
• Functional Keywords: pictet spengler condensation, dopamine, lyase
• Biological source: Thalictrum flavum subsp. glaucum (Yellow meadow rue)
• Total number of polymer chains: 3
• Total formula weight: 55576.25

Authors

Sula, A.,Lichman, B.R.,Pesnot, T.,Ward, J.M.,Hailes, H.C.,Keep, N.H. (deposition date: 2017-04-12, release date: 2017-09-27, Last modification date: 2017-10-18)

• Primary citation: Lichman, B.R.,Sula, A.,Pesnot, T.,Hailes, H.C.,Ward, J.M.,Keep, N.H.; Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase.; Biochemistry, 56:5274-5277, 2017; PubMed: 28915025; DOI: 10.1021/acs.biochem.7b00769

Experimental method

X-RAY DIFFRACTION (1.85 Å)