1RHO

STRUCTURE OF RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR

Summary for 1RHO

• Entry DOI: 10.2210/pdb1rho/pdb
• Descriptor: RHO GDP-DISSOCIATION INHIBITOR 1, SULFATE ION (3 entities in total)
• Functional Keywords: gtpase activation, phosphorylation, inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 50719.86

Authors

Keep, N.H.,Moody, P.C.E.,Roberts, G.C.K. (deposition date: 1996-10-12, release date: 1997-10-15, Last modification date: 2024-11-13)

Primary citation

Keep, N.H.,Barnes, M.,Barsukov, I.,Badii, R.,Lian, L.Y.,Segal, A.W.,Moody, P.C.,Roberts, G.C.
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.
Structure, 5:623-633, 1997

PubMed Abstract: The rho family of small G proteins, including rho, rac and cdc42, are involved in many cellular processes, including cell transformation by ras and the organization of the actin cytoskeleton. Additionally, rac has a role in the regulation of phagocyte NADPH oxidase. Guanine nucleotide dissociation inhibitors (GDIs) of the rhoGDI family bind to these G proteins and regulate their activity by preventing nucleotide dissociation and by controlling their interaction with membranes.

PubMed: 9195882
DOI: 10.1016/S0969-2126(97)00218-9

Experimental method

X-RAY DIFFRACTION (2.5 Å)