5H9F
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![BU of 5h9f by Molmil](/molmil-images/mine/5h9f) | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution. | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | Deposit date: | 2015-12-28 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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5H9E
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![BU of 5h9e by Molmil](/molmil-images/mine/5h9e) | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution. | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | Deposit date: | 2015-12-28 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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6C27
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![BU of 6c27 by Molmil](/molmil-images/mine/6c27) | SAM-III riboswitch ON-state | Descriptor: | COBALT HEXAMMINE(III), SAM-III riboswitch | Authors: | Grigg, J.C, Price, I.R, Ke, A. | Deposit date: | 2018-01-07 | Release date: | 2019-01-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.601 Å) | Cite: | Evidence for two-tiered conformation selection in the SAM-III riboswitch To Be Published
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8G9U
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![BU of 8g9u by Molmil](/molmil-images/mine/8g9u) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | CRISPR-associated protein, Csd1 family, Csd2 family, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-22 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8GAN
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![BU of 8gan by Molmil](/molmil-images/mine/8gan) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | Cas11, Cas5, Cas7, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-23 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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7R2K
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![BU of 7r2k by Molmil](/molmil-images/mine/7r2k) | elongated Cascade complex from type I-A CRISPR-Cas system | Descriptor: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | Authors: | Hu, C, Ni, D, Nam, K.H, Terns, M, Stahlberg, H, Ke, A. | Deposit date: | 2022-02-04 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural snapshots for an atypic type I CRISPR-Cas system To Be Published
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7R21
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![BU of 7r21 by Molmil](/molmil-images/mine/7r21) | elongated Cascade complex from type I-A CRISPR-Cas system | Descriptor: | Cas11a, Cas7a, CrRNA (62-MER), ... | Authors: | Hu, C, Ni, D, Nam, K.H, Stahlberg, H, Terns, M, Ke, A. | Deposit date: | 2022-02-04 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural snapshots for an atypic type I CRISPR-Cas system To Be Published
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8GAM
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![BU of 8gam by Molmil](/molmil-images/mine/8gam) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | Cas11, Cas5, Cas7, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-23 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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5XVO
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![BU of 5xvo by Molmil](/molmil-images/mine/5xvo) | E. fae Cas1-Cas2/prespacer/target ternary complex revealing DNA sampling and half-integration states | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | Deposit date: | 2017-06-28 | Release date: | 2017-10-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration. Nature, 550, 2017
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4JRC
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![BU of 4jrc by Molmil](/molmil-images/mine/4jrc) | Distal Stem I region from G. kaustophilus glyQS T box RNA | Descriptor: | Distal Stem I region of the glyQS T box leader RNA, MAGNESIUM ION | Authors: | Grigg, J.C, Ke, A. | Deposit date: | 2013-03-21 | Release date: | 2013-04-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.673 Å) | Cite: | T box RNA decodes both the information content and geometry of tRNA to affect gene expression. Proc.Natl.Acad.Sci.USA, 110, 2013
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3L7Z
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![BU of 3l7z by Molmil](/molmil-images/mine/3l7z) | Crystal structure of the S. solfataricus archaeal exosome | Descriptor: | Probable exosome complex RNA-binding protein 1, Probable exosome complex exonuclease 1, Probable exosome complex exonuclease 2, ... | Authors: | Lu, C, Ding, F, Ke, A. | Deposit date: | 2009-12-29 | Release date: | 2010-06-23 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring. Plos One, 5, 2010
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4MGM
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![BU of 4mgm by Molmil](/molmil-images/mine/4mgm) | |
4MGN
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![BU of 4mgn by Molmil](/molmil-images/mine/4mgn) | |
5U3G
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![BU of 5u3g by Molmil](/molmil-images/mine/5u3g) | Structure of the Dickeya dadantii ykkC riboswitch bound to guanidinium | Descriptor: | GUANIDINE, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Battaglia, R.A, Price, I.R, Ke, A. | Deposit date: | 2016-12-02 | Release date: | 2017-02-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for guanidine sensing by the ykkC family of riboswitches. RNA, 23, 2017
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5XVP
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![BU of 5xvp by Molmil](/molmil-images/mine/5xvp) | E. fae Cas1-Cas2/prespacer/target ternary complex revealing the fully integrated states | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(P*TP*TP*CP*TP*CP*CP*GP*AP*G)-3'), ... | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | Deposit date: | 2017-06-28 | Release date: | 2017-10-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration. Nature, 550, 2017
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6C66
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![BU of 6c66 by Molmil](/molmil-images/mine/6c66) | CRISPR RNA-guided surveillance complex, pre-nicking | Descriptor: | CRISPR-associated helicase, Cas3 family, CRISPR-associated protein, ... | Authors: | Xiao, Y, Luo, M, Liao, M, Ke, A. | Deposit date: | 2018-01-17 | Release date: | 2018-06-27 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structure basis for RNA-guided DNA degradation by Cascade and Cas3. Science, 361, 2018
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8GAF
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![BU of 8gaf by Molmil](/molmil-images/mine/8gaf) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | Cas11, Cas5, Cas7, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-22 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8G9S
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![BU of 8g9s by Molmil](/molmil-images/mine/8g9s) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | AcrIC8, Cas11, Cas5, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-22 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8G9T
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![BU of 8g9t by Molmil](/molmil-images/mine/8g9t) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | AcrIC9, Cas11, Cas5, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-22 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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7MI5
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![BU of 7mi5 by Molmil](/molmil-images/mine/7mi5) | Asymmetrical PAM-Non PAM prespacer bound Cas4/Cas1/Cas2 complex | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (26-MER), ... | Authors: | Hu, C.Y, Ke, A.K. | Deposit date: | 2021-04-16 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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7MI4
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![BU of 7mi4 by Molmil](/molmil-images/mine/7mi4) | Symmetrical PAM-PAM prespacer bound Cas4/Cas1/Cas2 complex | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (35-MER), ... | Authors: | Hu, C.Y, Ke, A.K. | Deposit date: | 2021-04-16 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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7MI9
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![BU of 7mi9 by Molmil](/molmil-images/mine/7mi9) | Full integration complex of Cas1/Cas2 from Cas4-containing system | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (5'-D(P*CP*GP*GP*AP*AP*AP*AP*GP*AP*GP*CP*C)-3'), ... | Authors: | Hu, C.Y, Ke, A.K. | Deposit date: | 2021-04-16 | Release date: | 2021-11-17 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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7MIB
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![BU of 7mib by Molmil](/molmil-images/mine/7mib) | |
7MID
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![BU of 7mid by Molmil](/molmil-images/mine/7mid) | Sub-complex of Cas4-Cas1-Cas2 bound PAM containing DNA | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (33-MER), ... | Authors: | Hu, C.Y, Ke, A.K. | Deposit date: | 2021-04-16 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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5U0A
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![BU of 5u0a by Molmil](/molmil-images/mine/5u0a) | CRISPR RNA-guided surveillance complex | Descriptor: | CRISPR-associated protein, Cas5e family, Cse1 family, ... | Authors: | Xiao, Y, Luo, M, Hayes, R.P, Kim, J, Ng, S, Ding, F, Liao, M, Ke, A. | Deposit date: | 2016-11-23 | Release date: | 2017-08-09 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System. Cell, 170, 2017
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