6OT1
 
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4G6F
 | | Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide | | 分子名称: | 10E8 Heavy Chain, 10E8 Light Chain, gp41 MPER Peptide | | 著者 | Ofek, G, Huang, J, Connors, M, Kwong, P.D. | | 登録日 | 2012-07-19 | | 公開日 | 2012-09-26 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Nature, 491, 2012
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6OSY
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6P7H
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4H8W
 | | Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4. | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ... | | 著者 | Tolbert, W.D, Acharya, P, Kwong, P.D, Pazgier, M. | | 登録日 | 2012-09-24 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
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6P60
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6P8D
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4HQQ
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6PEC
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6PEF
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6PDS
 | | Vaccine-elicited NHP FP-targeting antibody 0PV-a.04 in complex with HIV fusion peptide (residue 512-519) | | 分子名称: | HIV-1 fusion peptide residue 512-519, SULFATE ION, antibody 0PV-a.04 heavy chain, ... | | 著者 | Xu, K, Liu, K, Wang, Y, Kwong, P.D. | | 登録日 | 2019-06-19 | | 公開日 | 2020-06-24 | | 実験手法 | X-RAY DIFFRACTION (1.893 Å) | | 主引用文献 | Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
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6PDR
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4HPY
 | | Crystal structure of RV144-elicited antibody CH59 in complex with V2 peptide | | 分子名称: | CH59 Fab heavy chain, CH59 Fab light chain, Envelope glycoprotein gp160, ... | | 著者 | McLellan, J.S, Gorman, J, Haynes, B.F, Kwong, P.D. | | 登録日 | 2012-10-24 | | 公開日 | 2013-02-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2.
Immunity, 38, 2013
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4I3R
 | | Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... | | 著者 | Joyce, M.G, Biertumpfel, C, Nabel, G.J, Kwong, P.D. | | 登録日 | 2012-11-26 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.
J.Virol., 87, 2013
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6PDU
 | | Vaccine-elicited NHP FP-targeting antibody 13N024-a.01 in complex with HIV fusion peptide (residue 512-519) | | 分子名称: | HIV-1 fusion peptide residue 512-519, antibody 13N024-a.01, heavy chain, ... | | 著者 | Xu, K, Liu, K, Wang, Y, Kwong, P.D. | | 登録日 | 2019-06-19 | | 公開日 | 2020-06-24 | | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | | 主引用文献 | Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
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4JPW
 | | Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY 12A21, ... | | 著者 | Acharya, P, Luongo, T, Zhou, T, Kwong, P.D. | | 登録日 | 2013-03-19 | | 公開日 | 2013-04-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.904 Å) | | 主引用文献 | Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell(Cambridge,Mass.), 153, 2013
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6Q0S
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8D21
 | | Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer | | 分子名称: | 1B06 Heavy Chain, 1B06 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gorman, J, Kwong, P.D. | | 登録日 | 2022-05-27 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | | 主引用文献 | An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans.
Sci Transl Med, 15, 2023
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8D9Y
 | | Crystal structure of Taipan alpha-neurotoxin in complex with Centi-3FTX-D09 antibody | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Centi-3FTX-D09 Fab heavy chain, ... | | 著者 | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | 登録日 | 2022-06-12 | | 公開日 | 2023-06-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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8D9Z
 | | Crystal structure of Cobra alpha-neurotoxin in complex with Centi-3FTX-D09 antibody | | 分子名称: | ACETATE ION, Centi-3FTX-D09 Fab heavy chain, Centi-3FTX-D09 Fab light chain, ... | | 著者 | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | 登録日 | 2022-06-12 | | 公開日 | 2023-06-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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8DA1
 | | Crystal structure of Krait alpha-neurotoxin in complex with Centi-3FTX-D09 antibody | | 分子名称: | Alpha-bungarotoxin, Centi-3FTX-D09 Fab heavy chain, Centi-3FTX-D09 Fab light chain | | 著者 | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | 登録日 | 2022-06-12 | | 公開日 | 2023-06-14 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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8DA0
 | | Crystal structure of Mamba alpha-neurotoxin in complex with Centi-3FTX-D09 antibody | | 分子名称: | ACETATE ION, Alpha-elapitoxin-Dpp2d, Centi-3FTX-D09 Fab heavy chain, ... | | 著者 | Pletnev, S, Verardi, R, Tully, E.S, Glanville, J, Kwong, P.D. | | 登録日 | 2022-06-12 | | 公開日 | 2023-06-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Venom protection by antibody from a snakebite hyperimmune subject
To Be Published
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4HPO
 | | Crystal structure of RV144-elicited antibody CH58 in complex with V2 peptide | | 分子名称: | CH58 Fab heavy chain, CH58 Fab light chain, Envelope glycoprotein gp160, ... | | 著者 | McLellan, J.S, Gorman, J, Haynes, B.F, Kwong, P.D. | | 登録日 | 2012-10-24 | | 公開日 | 2013-02-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.694 Å) | | 主引用文献 | Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2.
Immunity, 38, 2013
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4I3S
 | | Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P21 | | 分子名称: | CALCIUM ION, Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... | | 著者 | Joyce, M.G, Biertumpfel, C, Nabel, G.J, Kwong, P.D. | | 登録日 | 2012-11-26 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.
J.Virol., 87, 2013
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8DEF
 | | Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW24 fab | | 分子名称: | SKW24 Fab heavy chain, SKW24 Fab light chain, Spike glycoprotein E1, ... | | 著者 | Pletnev, S, Tsybovsky, Y, Verardi, R, Roedeger, M, Kwong, P.D. | | 登録日 | 2022-06-20 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
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