8DA5
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8DA4
| Coevolved affibody-Z domain pair LL1.c2 | 分子名称: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | 登録日 | 2022-06-13 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA8
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8DA6
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8DAC
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8DA7
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8DAA
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8DAB
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8DZ8
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8FFE
| Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | 分子名称: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | 著者 | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | 登録日 | 2022-12-08 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
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5WB1
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5WB2
| US28 bound to engineered chemokine CX3CL1.35 and nanobodies | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ... | 著者 | Jude, K.M, Burg, J.S, Tsutsumi, N, Miles, T.F, Garcia, K.C. | 登録日 | 2017-06-27 | 公開日 | 2018-06-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. Elife, 7, 2018
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6BJ3
| TCR55 in complex with HIV(Pol448-456)/HLA-B35 | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, HIV Pol B35 peptide, ... | 著者 | Jude, K.M, Sibener, L.V, Garcia, K.C. | 登録日 | 2017-11-03 | 公開日 | 2018-07-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174, 2018
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6BJ8
| TCR55 in complex with Pep20/HLA-B35 | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | 著者 | Jude, K.M, Sibener, L.V, Yang, X, Garcia, K.C. | 登録日 | 2017-11-05 | 公開日 | 2018-07-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174, 2018
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6BJ2
| TCR589 in complex with HIV(Pol448-456)/HLA-B35 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | 著者 | Jude, K.M, Sibener, L.V, Garcia, K.C. | 登録日 | 2017-11-03 | 公開日 | 2018-07-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174, 2018
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7N3T
| TrkA ECD complex with designed miniprotein ligand | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jude, K.M, Cao, L, Garcia, K.C. | 登録日 | 2021-06-01 | 公開日 | 2022-04-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
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7RAA
| Designed StabIL-2 seq15 | 分子名称: | Interleukin-2, MAGNESIUM ION | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | 登録日 | 2021-06-30 | 公開日 | 2022-03-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RA9
| Designed StabIL-2 seq1 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | 登録日 | 2021-06-30 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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7T6F
| Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain | 分子名称: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ... | 著者 | Glassman, C.R, Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2021-12-13 | 公開日 | 2022-03-16 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science, 376, 2022
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3E2K
| Crystal Structure of the KPC-2 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) | 分子名称: | Beta-lactamase inhibitory protein, Carbapenemase | 著者 | Hanes, M.S, Jude, K.M, Berger, J.M, Bonomo, R.A, Handel, T.M. | 登録日 | 2008-08-05 | 公開日 | 2009-08-04 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein Biochemistry, 48, 2009
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6NDZ
| Designed repeat protein in complex with Fz8 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ACETIC ACID, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-14 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.264 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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6NE2
| Designed repeat protein in complex with Fz7 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-15 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.299 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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6NE1
| Designed repeat protein in complex with Fz4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Pfs, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-15 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.011 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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6NE4
| Designed repeat protein specifically in complex with Fz7CRD | 分子名称: | 1,2-ETHANEDIOL, Designed repeat binding protein, Frizzled-7, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-16 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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8G04
| Structure of signaling thrombopoietin-MPL receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ... | 著者 | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | 登録日 | 2023-01-31 | 公開日 | 2023-08-30 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell, 186, 2023
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