7PFO
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![BU of 7pfo by Molmil](/molmil-images/mine/7pfo) | Core human replisome | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ... | Authors: | Jones, M.J, Yeeles, J.T.P. | Deposit date: | 2021-08-11 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of a human replisome shows the organisation and interactions of a DNA replication machine. Embo J., 40, 2021
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7PLO
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![BU of 7plo by Molmil](/molmil-images/mine/7plo) | H. sapiens replisome-CUL2/LRR1 complex | Descriptor: | Cell division control protein 45 homolog, Claspin, Cullin-2, ... | Authors: | Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M. | Deposit date: | 2021-09-01 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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6SXB
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![BU of 6sxb by Molmil](/molmil-images/mine/6sxb) | XPF-ERCC1 Cryo-EM Structure, DNA-Bound form | Descriptor: | DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3'), DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3'), DNA excision repair protein ERCC-1, ... | Authors: | Jones, M.L, Briggs, D.C, McDonald, N.Q. | Deposit date: | 2019-09-25 | Release date: | 2020-03-11 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nat Commun, 11, 2020
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6SXA
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![BU of 6sxa by Molmil](/molmil-images/mine/6sxa) | XPF-ERCC1 Cryo-EM Structure, Apo-form | Descriptor: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF | Authors: | Jones, M.L, Briggs, D.C, McDonald, N.Q. | Deposit date: | 2019-09-25 | Release date: | 2020-03-11 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nat Commun, 11, 2020
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8B9D
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![BU of 8b9d by Molmil](/molmil-images/mine/8b9d) | Human replisome bound by Pol Alpha | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA Molecule, ... | Authors: | Jones, M.L, Yeeles, J.T.P. | Deposit date: | 2022-10-05 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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8B9C
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![BU of 8b9c by Molmil](/molmil-images/mine/8b9c) | S. cerevisiae pol alpha - replisome complex | Descriptor: | Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... | Authors: | Jones, M.L, Yeeles, J.T.P. | Deposit date: | 2022-10-05 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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8B9B
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![BU of 8b9b by Molmil](/molmil-images/mine/8b9b) | |
8B9A
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![BU of 8b9a by Molmil](/molmil-images/mine/8b9a) | |
2TGD
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![BU of 2tgd by Molmil](/molmil-images/mine/2tgd) | |
3V01
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![BU of 3v01 by Molmil](/molmil-images/mine/3v01) | Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | Authors: | Heald, R, Jackson, P, Savy, P, Jones, M, Gancia, E, Burton, B, Newman, R, Boggs, J, Chan, E, Chan, J, Choo, E, Merchant, M, Ultsch, M, Wiesmann, C, Belvin, M, Price, S. | Deposit date: | 2011-12-07 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions. J.Med.Chem., 55, 2012
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1MPS
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![BU of 1mps by Molmil](/molmil-images/mine/1mps) | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH PHE M 197 REPLACED WITH ARG AND TYR M 177 REPLACED WITH PHE (CHAIN M, Y177F, F197R) | Descriptor: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, FE (II) ION, ... | Authors: | Mcauley-Hecht, K.E, Fyfe, P.K, Ridge, J.P, Prince, S, Hunter, C.N, Isaacs, N.W, Cogdell, R.J, Jones, M.R. | Deposit date: | 1998-03-09 | Release date: | 1998-10-14 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural studies of wild-type and mutant reaction centers from an antenna-deficient strain of Rhodobacter sphaeroides: monitoring the optical properties of the complex from bacterial cell to crystal. Biochemistry, 37, 1998
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1W7E
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![BU of 1w7e by Molmil](/molmil-images/mine/1w7e) | |
1W7D
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![BU of 1w7d by Molmil](/molmil-images/mine/1w7d) | |
6M9I
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![BU of 6m9i by Molmil](/molmil-images/mine/6m9i) | L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | Descriptor: | Ice nucleation protein | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2018-08-23 | Release date: | 2019-03-27 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ, 6, 2019
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6M7M
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![BU of 6m7m by Molmil](/molmil-images/mine/6m7m) | rac-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | Descriptor: | L-GSTSTA from ice nucleation protein, inaZ, and its enantiomer, ... | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2018-08-20 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.101 Å) | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ, 6, 2019
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6M9J
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![BU of 6m9j by Molmil](/molmil-images/mine/6m9j) | Racemic-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | Descriptor: | Ice nucleation protein | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2018-08-23 | Release date: | 2019-03-27 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ, 6, 2019
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7N2G
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![BU of 7n2g by Molmil](/molmil-images/mine/7n2g) | MicroED structure of human CPEB3 segment(154-161) kinked polymorph phased by ARCIMBOLDO-BORGES | Descriptor: | CPEB3 | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.201 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2J
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![BU of 7n2j by Molmil](/molmil-images/mine/7n2j) | MicroED structure of a mutant mammalian prion segment phased by ARCIMBOLDO-BORGES | Descriptor: | prion protein | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2F
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![BU of 7n2f by Molmil](/molmil-images/mine/7n2f) | MicroED structure of human CPEB3 segment (154-161) straight polymorph phased by ARCIMBOLDO-BORGES | Descriptor: | CPEB3 | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.2 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2K
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![BU of 7n2k by Molmil](/molmil-images/mine/7n2k) | MicroED structure of sequence variant of repeat segment of the yeast prion New1p phased by ARCIMBOLDO-BORGES | Descriptor: | prion New1p | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.301 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2L
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![BU of 7n2l by Molmil](/molmil-images/mine/7n2l) | MicroED structure of a mutant mammalian prion segment | Descriptor: | prion protein | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2I
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![BU of 7n2i by Molmil](/molmil-images/mine/7n2i) | MicroED structure of human LECT2 (45-53) phased by ARCIMBOLDO-BORGES | Descriptor: | LECT2 | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.402 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2H
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![BU of 7n2h by Molmil](/molmil-images/mine/7n2h) | X-Ray structure of a sequence variant of a repeat segment of the yeast prion New1p | Descriptor: | prion New1p | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.102 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2D
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![BU of 7n2d by Molmil](/molmil-images/mine/7n2d) | MicroED structure of human zinc finger protein 292 segment (534-542) phased by ARCIMBOLDO-BORGES | Descriptor: | DIMETHYL SULFOXIDE, zinc finger protein 292 | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-28 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.503 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2E
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![BU of 7n2e by Molmil](/molmil-images/mine/7n2e) | MicroED structure of human CPEB3 segment (154-161) straight polymorph | Descriptor: | CPEB3 | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2024-05-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1 Å) | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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