6RZ3
 
 | | Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP | | 分子名称: | Cellular tumor antigen p53, RelA-associated inhibitor, ZINC ION | | 著者 | Chen, S, Ren, J, Jones, E.Y, Lu, X. | | 登録日 | 2019-06-12 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (4.23 Å) | | 主引用文献 | iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Proc.Natl.Acad.Sci.USA, 116, 2019
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2L21
 | | chicken IGF2R domain 11 | | 分子名称: | Cation-independent mannose-6-phosphate receptor | | 著者 | Williams, C, Hoppe, H, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Rezgui, D.Z, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-10 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | CD loop dependency of the IGF2: M6P/IGF2 receptor binding interaction predates imprinting
To be Published
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2L29
 | | Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II | | 分子名称: | Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-13 | | 公開日 | 2012-02-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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6S9F
 | | Drosophila OTK, extracellular domains 3-5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tyrosine-protein kinase-like otk | | 著者 | Rozbesky, D, Jones, E.Y. | | 登録日 | 2019-07-12 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.969 Å) | | 主引用文献 | Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.
Structure, 28, 2020
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6SNW
 | | Structure of Coxsackievirus A10 complexed with its receptor KREMEN1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, Capsid protein VP3, ... | | 著者 | Zhao, Y, Zhou, D, Ni, T, Karia, D, Kotecha, A, Wang, X, Rao, Z, Jones, E.Y, Fry, E.E, Ren, J, Stuart, D.I. | | 登録日 | 2019-08-27 | | 公開日 | 2020-01-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Nat Commun, 11, 2020
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6SMG
 | | Structure of Coxsackievirus A10 | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | 著者 | Zhao, Y, Zhou, D, Ni, T, Karia, D, Kotecha, A, Wang, X, Rao, Z, Jones, E.Y, Fry, E.E, Ren, J, Stuart, D.I. | | 登録日 | 2019-08-21 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Nat Commun, 11, 2020
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6SNB
 | | Structure of Coxsackievirus A10 A-particle | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | 著者 | Zhao, Y, Zhou, D, Ni, T, Karia, D, Kotecha, A, Wang, X, Rao, Z, Jones, E.Y, Fry, E.E, Ren, J, Stuart, D.I. | | 登録日 | 2019-08-23 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Nat Commun, 11, 2020
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6T2H
 | | Furano[2,3-d]prymidine amides as Notum inhibitors | | 分子名称: | 1,2-ETHANEDIOL, 2-[[(4~{S})-5-chloranyl-6-methyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-4-yl]sulfanyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-10-08 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
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6TFM
 | | Frizzled8 CRD | | 分子名称: | Frizzled-8 | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-11-14 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8.
J.Med.Chem., 63, 2020
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4GZA
 | | Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1 | | 分子名称: | CALCIUM ION, Neuropilin-1, Plexin-A2, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (7 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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6TFB
 | | Carbamazepine binds Frizzled8 | | 分子名称: | Frizzled-8, GLYCEROL, benzo[b][1]benzazepine-11-carboxamide | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-11-13 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8.
J.Med.Chem., 63, 2020
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6T2K
 | | Furano[2,3-d]prymidine amides as Notum inhibitors | | 分子名称: | 1,2-ETHANEDIOL, 2-(6-chloranyl-7-cyclopropyl-thieno[3,2-d]pyrimidin-4-yl)sulfanylethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-10-08 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
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6R8P
 | | Notum fragment 723 | | 分子名称: | 2-(2-methylphenoxy)-~{N}-pyridin-3-yl-ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-04-02 | | 公開日 | 2019-05-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Medchemcomm, 10, 2019
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4GZ8
 | | Mouse Semaphorin 3A, domains Sema-PSI-IG | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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2L2A
 | | Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-13 | | 公開日 | 2012-02-15 | | 最終更新日 | 2012-12-12 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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4GZ9
 | | Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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2L2G
 | | Solution structure of Opossum Domain 11 | | 分子名称: | IGF2R DOMAIN 11 | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Rezgui, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Bassim, A.H. | | 登録日 | 2010-08-18 | | 公開日 | 2012-02-15 | | 最終更新日 | 2015-02-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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5FWV
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5FWS
 | | Wnt modulator Kremen crystal form I at 1.90A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, KREMEN PROTEIN 1, ... | | 著者 | Zebisch, M, Jackson, V.A, Jones, E.Y. | | 登録日 | 2016-02-21 | | 公開日 | 2016-07-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf
Structure, 24, 2016
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5FMV
 | | Crystal structure of human CD45 extracellular region, domains d1-d4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION | | 著者 | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | | 登録日 | 2015-11-09 | | 公開日 | 2016-03-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
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5FN6
 | | Crystal structure of human CD45 extracellular region, domains d1-d3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C | | 著者 | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | | 登録日 | 2015-11-10 | | 公開日 | 2016-03-23 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
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5FN8
 | | Crystal structure of rat CD45 extracellular region, domains d3-d4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C | | 著者 | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | | 登録日 | 2015-11-11 | | 公開日 | 2016-03-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
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5FN7
 | | Crystal structure of human CD45 extracellular region, domains d1-d2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C | | 著者 | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | | 登録日 | 2015-11-10 | | 公開日 | 2016-03-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
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5FWU
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3OKT
 | | Mouse Plexin A2, extracellular domains 1-4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | | 著者 | Janssen, B.J.C, Robinson, R.A, Bell, C.H, Siebold, C, Jones, E.Y. | | 登録日 | 2010-08-25 | | 公開日 | 2010-10-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | | 主引用文献 | Structural basis of semaphorin-plexin signalling.
Nature, 467, 2010
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