6R8P
Notum fragment 723
Summary for 6R8P
Entry DOI | 10.2210/pdb6r8p/pdb |
Descriptor | Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (7 entities in total) |
Functional Keywords | notum inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 45445.71 |
Authors | Zhao, Y.,Jones, E.Y. (deposition date: 2019-04-02, release date: 2019-05-08, Last modification date: 2020-07-29) |
Primary citation | Atkinson, B.N.,Steadman, D.,Zhao, Y.,Sipthorp, J.,Vecchia, L.,Ruza, R.R.,Jeganathan, F.,Lines, G.,Frew, S.,Monaghan, A.,Kjær, S.,Bictash, M.,Jones, E.Y.,Fish, P.V. Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. Medchemcomm, 10:1361-1369, 2019 Cited by PubMed: 31534655DOI: 10.1039/c9md00096h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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