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PDB: 97 件

3RZF
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Crystal Structure of Inhibitor of kappaB kinase beta (I4122)
分子名称: (4-{[4-(4-chlorophenyl)pyrimidin-2-yl]amino}phenyl)[4-(2-hydroxyethyl)piperazin-1-yl]methanone, MGC80376 protein
著者Xu, G, Lo, Y.C, Li, Q, Napolitano, G, Wu, X, Jiang, X, Dreano, M, Karin, M, Wu, H.
登録日2011-05-11
公開日2011-05-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Crystal structure of inhibitor of KappaB kinase Beta.
Nature, 472, 2011
7NL6
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Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand
分子名称: CALCIUM ION, DC-SIGN, CRD domain, ...
著者Jakob, R.P, Cramer, J, Lakkaichi, A, Aliu, B, Cattaneo, I, Klein, S, Jiang, X, Rabbani, S, Schwardt, O, Ernst, B, Maier, T.
登録日2021-02-22
公開日2021-10-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2.
J.Am.Chem.Soc., 143, 2021
7NL7
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Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand
分子名称: 3-Aminopropyl 2-deoxy-2-(4-phenyl-1,2,3-triazol-1-yl)-alpha-D-mannopyranoside, CALCIUM ION, DC-SIGN, ...
著者Jakob, R.P, Cramer, J, Lakkaichi, A, Aliu, B, Cattaneo, I, Klein, S, Jiang, X, Rabbani, S, Schwardt, O, Ernst, B, Maier, T.
登録日2021-02-22
公開日2021-10-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2.
J.Am.Chem.Soc., 143, 2021
4ESR
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Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors
分子名称: DI(HYDROXYETHYL)ETHER, Jouberin
著者Van Petegem, X.F, Liu, P.X, Lobo, P, Jiang, X.
登録日2012-04-23
公開日2012-06-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors.
Proteomics, 12, 2012
6UT9
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Crystal structure of the carbohydrate-binding domain VP8* of human P[4] rotavirus strain BM5265
分子名称: Outer capsid protein VP4
著者Xu, S, Stuckert, M, Burnside, R, McGinnis, K, Jiang, X, Kennedy, M.A.
登録日2019-10-29
公開日2020-11-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens.
Proc.Natl.Acad.Sci.USA, 118, 2021
6VKX
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Crystal structure of the carbohydrate-binding domain VP8* of human P[8] rotavirus strain BM13851
分子名称: DI(HYDROXYETHYL)ETHER, Outer capsid protein VP4, TETRAETHYLENE GLYCOL
著者Xu, S, McGinnis, K.R, Jiang, X, Kennedy, M.A.
登録日2020-01-22
公開日2021-01-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens.
Proc.Natl.Acad.Sci.USA, 118, 2021
5K0X
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Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541
分子名称: (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide, CHLORIDE ION, Tyrosine-protein kinase Mer
著者McIver, A.L, Zhang, W, Liu, Q, Jiang, X, Stashko, M.A, Nichols, J, Miley, M.J, Norris-Drouin, J, Machius, M, DeRyckere, D, Wood, E, Graham, D.K, Earp, H.S, Kireev, D, Frye, S.V, Wang, X.
登録日2016-05-17
公開日2017-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.231 Å)
主引用文献Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem, 12, 2017
6JKF
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Crystal structure of Serratia marcescens Chitinase B complexed with compound 2-8-s2
分子名称: 6-azanyl-11-methyl-2-oxidanylidene-7-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)-1,9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, Chitinase
著者Yang, Q, Jiang, X.
登録日2019-02-28
公開日2020-02-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.
J.Med.Chem., 63, 2020
5ERG
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Crystal structure of the two-subunit tRNA m1A58 methyltransferase TRM6-TRM61 in complex with SAM
分子名称: S-ADENOSYLMETHIONINE, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
著者Zhu, Y, Wang, M, Wang, C, Fan, X, Jiang, X, Teng, M, Li, X.
登録日2015-11-14
公開日2016-09-14
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.202 Å)
主引用文献Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Sci Rep, 6, 2016
5EQJ
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Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae
分子名称: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
著者Zhu, Y, Wang, M, Wang, C, Fan, X, Jiang, X, Teng, M, Li, X.
登録日2015-11-13
公開日2016-09-14
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Sci Rep, 6, 2016
6FXN
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Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab
分子名称: Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain
著者Lammens, A, Maskos, K, Willen, L, Jiang, X, Schneider, P.
登録日2018-03-09
公開日2018-04-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Nat Commun, 9, 2018
6NIW
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Crystal structure of P[6] rotavirus
分子名称: DI(HYDROXYETHYL)ETHER, Protease-sensitive outer capsid protein
著者Xu, S, Liu, Y, Lakamp, L, Ahmed, L, Jiang, X, Kennedy, M.A.
登録日2019-01-01
公開日2020-01-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens.
Plos Pathog., 16, 2020
6OAI
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Crystal structure of P[6] rotavirus vp8* complexed with LNFPI
分子名称: Protease-sensitive outer capsid protein, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Xu, S, Liu, Y, Jiang, X, Kennedy, M.A.
登録日2019-03-16
公開日2020-03-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens.
Plos Pathog., 16, 2020
1Z1D
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Structural Model for the interaction between RPA32 C-terminal domain and SV40 T antigen origin binding domain.
分子名称: Large T antigen, Replication protein A 32 kDa subunit
著者Arunkumar, A.I, Klimovich, V, Jiang, X, Ott, R.D, Mizoue, L, Fanning, E, Chazin, W.J.
登録日2005-03-03
公開日2005-05-17
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome.
Nat.Struct.Mol.Biol., 12, 2005
5DPM
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Crystal structure of UbiG mutant in complex with SAH
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, Ubiquinone biosynthesis O-methyltransferase
著者Zhu, Y, Jiang, X, Li, X, Teng, M.
登録日2015-09-13
公開日2016-09-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of UbiG mutant in complex with SAH at 2.1 angstroms resolution
To Be Published
7SPT
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Crystal structure of exofacial state human glucose transporter GLUT3
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ...
著者Wang, N, Jiang, X, Yan, N.
登録日2021-11-03
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.
Nat Commun, 13, 2022
7SPS
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Crystal structure of human glucose transporter GLUT3 bound with exofacial inhibitor SA47
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ...
著者Wang, N, Jiang, X, Yan, N.
登録日2021-11-03
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.
Nat Commun, 13, 2022
5DAF
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Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64063
分子名称: (5aS,6S,9aS)-7-hydroxy-2,6,9a-trimethyl-3-(pyridin-3-yl)-4,5,5a,6,9,9a-hexahydro-2H-benzo[g]indazole-8-carbonitrile, Kelch-like ECH-associated protein 1
著者Huerta, C, Jiang, X, Trevino, I, Bender, C.F, Swinger, K.K, Stoll, V.S, Ferguson, D.A, Thomas, P.J, Probst, B, Dulubova, I, Visnick, M, Wigley, W.C.
登録日2015-08-19
公開日2016-08-10
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
Biochim.Biophys.Acta, 1860, 2016
5DAD
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Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64014
分子名称: (6aS,7S,10aS)-8-hydroxy-4-methoxy-2,7,10a-trimethyl-5,6,6a,7,10,10a-hexahydrobenzo[h]quinazoline-9-carbonitrile, Kelch-like ECH-associated protein 1
著者Huerta, C, Jiang, X, Trevino, I, Bender, C.F, Swinger, K.K, Stoll, V.S, Ferguson, D.A, Thomas, P.J, Probst, B, Dulubova, I, Visnick, M, Wigley, W.C.
登録日2015-08-19
公開日2016-08-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
Biochim.Biophys.Acta, 1860, 2016
4RDJ
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Crystal structure of Norovirus Boxer P domain
分子名称: Capsid
著者Hao, N, Chen, Y, Xia, M, Liu, W, Tan, M, Jiang, X, Li, X.
登録日2014-09-19
公開日2015-01-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of GI.8 Boxer virus P dimers in complex with HBGAs, a novel evolutionary path selected by the Lewis epitope.
Protein Cell, 6, 2015
2LIT
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NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in reduced states
分子名称: Cytochrome c iso-1, HEME C
著者Lan, W, Wang, Z, Yang, Z, Zhu, J, Ying, T, Jiang, X, Zhang, X, Wu, H, Liu, M, Tan, X, Cao, C, Huang, Z.X.
登録日2011-08-31
公開日2011-12-07
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
2LIR
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NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in oxidized states
分子名称: Cytochrome c iso-1, HEME C
著者Lan, W, Wang, Z, Yang, Z, Zhu, J, Ying, T, Jiang, X, Zhang, X, Wu, H, Liu, M, Tan, X, Cao, C, Huang, Z.X.
登録日2011-08-31
公開日2011-12-07
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
4ZCH
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Single-chain human APRIL-BAFF-BAFF Heterotrimer
分子名称: TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B
著者Lammens, A, Jiang, X, Maskos, K, Schneider, P.
登録日2015-04-16
公開日2015-05-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
J.Biol.Chem., 290, 2015
5WZZ
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The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation
分子名称: Axin-1, E3 ubiquitin-protein ligase SIAH1, ZINC ION
著者Ji, L, Jiang, B, Jiang, X, Charlat, O, Chen, A, Mickanin, C, Bauer, A, Xu, W, Yan, X.-X, Cong, F.
登録日2017-01-19
公開日2017-08-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.103 Å)
主引用文献The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation
Genes Dev., 31, 2017
2OBR
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Crystal Structures of P Domain of Norovirus VA387
分子名称: Capsid protein
著者Cao, S, Lou, Z, Jiang, X, Zhang, X.C, Li, X, Rao, Z.
登録日2006-12-20
公開日2007-04-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the recognition of blood group trisaccharides by norovirus.
J.Virol., 81, 2007

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