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PDB: 249 results

4PZV
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Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D
Descriptor: 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine
Authors:Shaw, G.X, Shi, G, Ji, X.
Deposit date:2014-03-31
Release date:2014-07-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.704 Å)
Cite:Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.
Febs J., 281, 2014
6AN6
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Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-72
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine
Authors:Shaw, G.X, Shi, G, Ji, X.
Deposit date:2017-08-12
Release date:2018-08-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bisubstrate analogue inhibitors of HPPK: Transition state mimetics
to be published
6AN4
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Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-39 (J1F)
Descriptor: ((2-(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carboxamido)-N-(2-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)amino)-2-oxoethyl)acetamido)methyl)phosphonic acid, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION
Authors:Shaw, G.X, Shi, G, Ji, X.
Deposit date:2017-08-12
Release date:2018-08-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Bisubstrate analog inhibitors of HPPK: Transition state mimetics
to be published
2HHD
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OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA-CHAINS IN HUMAN AND BOVINE HEMOGLOBIN
Descriptor: HEMOGLOBIN (DEOXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Gilliland, G.L, Pechik, I, Fronticelli, C, Ji, X.
Deposit date:1994-09-29
Release date:1995-01-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin.
Biochemistry, 35, 1996
2HK8
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Crystal structure of shikimate dehydrogenase from aquifex aeolicus at 2.35 angstrom resolution
Descriptor: Shikimate dehydrogenase
Authors:Gan, J.H, Prabakaran, P, Gu, Y.J, Andrykovitch, M, Li, Y, Liu, H.H, Yan, H, Ji, X.
Deposit date:2006-07-03
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.
Biochemistry, 46, 2007
2HK9
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Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with shikimate and NADP+ at 2.2 angstrom resolution
Descriptor: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Gan, J.H, Prabakaran, P, Gu, Y.J, Andrykovitch, M, Li, Y, Liu, H.H, Yan, H, Ji, X.
Deposit date:2006-07-03
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.
Biochemistry, 46, 2007
2HK7
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Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with mercury at 2.5 angstrom resolution
Descriptor: MERCURY (II) ION, Shikimate dehydrogenase
Authors:Gan, J.H, Prabakaran, P, Gu, Y.J, Andrykovitch, M, Li, Y, Liu, H.H, Yan, H, Ji, X.
Deposit date:2006-07-03
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.
Biochemistry, 46, 2007
6AP9
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Crystal Structure of hGSTP1-1 with S-nitrosation of Cys101
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, CALCIUM ION, ...
Authors:Kumari, V, Ji, X.
Deposit date:2017-08-17
Release date:2018-08-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Cysteine S-nitrosylation of hGSTP1-1 by nitric oxide (NO)-releasing prodrugs
to be published
1AJ9
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R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S
Descriptor: CARBON MONOXIDE, HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), ...
Authors:Vasquez, G.B, Ji, X, Fronticelli, C, Gilliland, G.L.
Deposit date:1997-05-16
Release date:1998-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins.
Acta Crystallogr.,Sect.D, 54, 1998
1NPR
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS NUSG IN C222(1)
Descriptor: Transcription antitermination protein nusG
Authors:Knowlton, J.R, Bubunenko, M, Andrykovitch, M, Guo, W, Routzhan, K.M, Waugh, D.S, Court, D.L, Ji, X.
Deposit date:2003-01-18
Release date:2003-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:A Spring-Loaded State of NusG in Its Functional Cycle Is Suggested by X-ray Crystallography and Supported by Site-Directed Mutants
Biochemistry, 42, 2003
1NPP
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BU of 1npp by Molmil
CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS NUSG IN P2(1)
Descriptor: ISOPROPYL ALCOHOL, Transcription antitermination protein nusG
Authors:Knowlton, J.R, Bubunenko, M, Andrykovitch, M, Guo, W, Routzahn, K.M, Waugh, D.S, Court, D.L, Ji, X.
Deposit date:2003-01-18
Release date:2003-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Spring-Loaded State of NusG in Its Functional Cycle Is Suggested by X-ray Crystallography and Supported by Site-Directed Mutants
Biochemistry, 42, 2003
3FTD
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BU of 3ftd by Molmil
Crystal structure of A. aeolicus KsgA at 1.44-Angstrom resolution
Descriptor: Dimethyladenosine transferase
Authors:Tu, C, Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
3FTF
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Crystal structure of A. aeolicus KsgA in complex with RNA and SAH
Descriptor: 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3', Dimethyladenosine transferase, POTASSIUM ION, ...
Authors:Tu, C, Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
3DJ9
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BU of 3dj9 by Molmil
Crystal Structure of an isolated, unglycosylated antibody CH2 domain
Descriptor: Ig gamma-1 chain C region
Authors:Prabakaran, P, Vu, B.K, Gan, J, Dimitrov, D.S, Ji, X.
Deposit date:2008-06-22
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of an isolated unglycosylated antibody C(H)2 domain.
Acta Crystallogr.,Sect.D, 64, 2008
3FTC
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BU of 3ftc by Molmil
Crystal structure of A. aeolicus KsgA at 1.72-Angstrom resolution
Descriptor: Dimethyladenosine transferase
Authors:Tu, C, Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
1B48
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BU of 1b48 by Molmil
CRYSTAL STRUCTURE OF MGSTA4-4 IN COMPLEX WITH GSH CONJUGATE OF 4-HYDROXYNONENAL IN ONE SUBUNIT AND GSH IN THE OTHER: EVIDENCE OF SIGNALING ACROSS DIMER INTERFACE IN MGSTA4-4
Descriptor: 4-S-GLUTATHIONYL-5-PENTYL-TETRAHYDRO-FURAN-2-OL, GLUTATHIONE, PROTEIN (GLUTATHIONE S-TRANSFERASE)
Authors:Xiao, B, Zimniak, P, Ji, X.
Deposit date:1999-01-06
Release date:1999-09-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface.
Biochemistry, 38, 1999
3FTE
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BU of 3fte by Molmil
Crystal structure of A. aeolicus KsgA in complex with RNA
Descriptor: 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3', Dimethyladenosine transferase
Authors:Tu, C, Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
1ESR
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BU of 1esr by Molmil
CRYSTAL STRUCTURE OF HUMAN MONOCYTE CHEMOTACTIC PROTEIN-2
Descriptor: MONOCYTE CHEMOTACTIC PROTEIN 2
Authors:Blaszczyk, J, Ji, X.
Deposit date:2000-04-10
Release date:2000-12-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.
Biochemistry, 39, 2000
1RHH
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BU of 1rhh by Molmil
Crystal Structure of the Broadly HIV-1 Neutralizing Fab X5 at 1.90 Angstrom Resolution
Descriptor: Fab X5, heavy chain, light chain
Authors:Darbha, R, Phogat, S, Labrijn, A.F, Shu, Y, Gu, Y, Andrykovitch, M, Zhang, M.Y, Pantophlet, R, Martin, L, Vita, C, Burton, D.R, Dimitrov, D.S, Ji, X.
Deposit date:2003-11-14
Release date:2004-02-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope
Biochemistry, 43, 2004
1EX6
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BU of 1ex6 by Molmil
CRYSTAL STRUCTURE OF UNLIGANDED FORM OF GUANYLATE KINASE FROM YEAST
Descriptor: GUANYLATE KINASE
Authors:Blaszczyk, J, Ji, X.
Deposit date:2000-05-01
Release date:2001-03-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of unligated guanylate kinase from yeast reveals GMP-induced conformational changes.
J.Mol.Biol., 307, 2001
1EX7
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BU of 1ex7 by Molmil
CRYSTAL STRUCTURE OF YEAST GUANYLATE KINASE IN COMPLEX WITH GUANOSINE-5'-MONOPHOSPHATE
Descriptor: GUANOSINE-5'-MONOPHOSPHATE, GUANYLATE KINASE, SULFATE ION
Authors:Blaszczyk, J, Ji, X.
Deposit date:2000-05-01
Release date:2001-03-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of unligated guanylate kinase from yeast reveals GMP-induced conformational changes.
J.Mol.Biol., 307, 2001
3ILL
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BU of 3ill by Molmil
Crystal structure of E. coli HPPK(D97A)
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION
Authors:Blaszczyk, J, Li, Y, Yan, H, Ji, X.
Deposit date:2009-08-07
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural and functional roles of residues D95 and D97 in E. coli HPPK
To be Published
3ILI
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BU of 3ili by Molmil
Crystal structure of E. coli HPPK(D95A)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, ...
Authors:Blaszczyk, J, Li, Y, Yan, H, Ji, X.
Deposit date:2009-08-07
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional roles of residues D95 and D97 in E. coli HPPK
To be Published
1I4S
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BU of 1i4s by Molmil
CRYSTAL STRUCTURE OF RNASE III ENDONUCLEASE DOMAIN FROM AQUIFEX AEOLICUS AT 2.15 ANGSTROM RESOLUTION
Descriptor: RIBONUCLEASE III
Authors:Blaszczyk, J, Ji, X.
Deposit date:2001-02-22
Release date:2001-12-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage.
Structure, 9, 2001
3HSZ
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BU of 3hsz by Molmil
Crystal structure of E. coli HPPK(F123A)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Blaszczyk, J, Li, Y, Yan, H, Ji, X.
Deposit date:2009-06-11
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published

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