4PZV

Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D

Summary for 4PZV

Entry DOI	10.2210/pdb4pzv/pdb
Related	4F7V
Descriptor	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	ferredoxin-like fold; tim barrel fold, transferase, atp binding, phosphorylation
Biological source	Francisella tularensis subsp. tularensis
Total number of polymer chains	1
Total formula weight	49382.92
Authors	Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2014-03-31, release date: 2014-07-16, Last modification date: 2023-09-20)
Primary citation	Shaw, G.X.,Li, Y.,Shi, G.,Wu, Y.,Cherry, S.,Needle, D.,Zhang, D.,Tropea, J.E.,Waugh, D.S.,Yan, H.,Ji, X. Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis. Febs J., 281:4123-4137, 2014 Cited by PubMed: 24975935 DOI: 10.1111/febs.12896 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.704 Å)

Structure validation