4F7V
Crystal structure of E. coli HPPK in complex with bisubstrate analogue inhibitor J1D (HP26)
Summary for 4F7V
Entry DOI | 10.2210/pdb4f7v/pdb |
Related | 1EX8 3UD5 3UDE 3UDV |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine (3 entities in total) |
Functional Keywords | alpha beta, pyrophosphokinase, pyrophosphoryl transfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 18601.16 |
Authors | |
Primary citation | Shi, G.,Shaw, G.,Li, Y.,Wu, Y.,Yan, H.,Ji, X. Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode. Bioorg.Med.Chem., 20:4303-4309, 2012 Cited by PubMed: 22727779DOI: 10.1016/j.bmc.2012.05.060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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