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PDB: 3275 results

4MNE
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Crystal structure of the BRAF:MEK1 complex
Descriptor: 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G.
Deposit date:2013-09-10
Release date:2014-06-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8483 Å)
Cite:Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
4DD0
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EVAL processed HEWL, cisplatin aqueous glycerol
Descriptor: GLYCEROL, Lysozyme C
Authors:Tanley, S.W, Schreurs, A.M, Kroon-Batenburg, L.M, Meredith, J, Prendergast, R, Walsh, D, Bryant, P, Levy, C, Helliwell, J.R.
Deposit date:2012-01-18
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural studies of the effect that dimethyl sulfoxide (DMSO) has on cisplatin and carboplatin binding to histidine in a protein.
Acta Crystallogr.,Sect.D, 68, 2012
4DLI
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BU of 4dli by Molmil
Human p38 MAP kinase in complex with RL87
Descriptor: Mitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine
Authors:Gruetter, C, Getlik, M, Simard, J.R, Rauh, D.
Deposit date:2012-02-06
Release date:2013-01-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38alpha kinase.
Plos One, 7, 2012
4MNF
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Crystal structure of BRAF-V600E bound to GDC0879
Descriptor: 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, Serine/threonine-protein kinase B-raf
Authors:Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G.
Deposit date:2013-09-10
Release date:2014-06-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
1QIB
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BU of 1qib by Molmil
CRYSTAL STRUCTURE OF GELATINASE A CATALYTIC DOMAIN
Descriptor: 72 kDa type IV collagenase, CALCIUM ION, ZINC ION
Authors:Dhanaraj, V, Williams, M.G, Ye, Q.-Z, Molina, F, Johnson, L.L, Ortwine, D.F, Pavlovsky, A, Rubin, J.R, Skeean, R.W, White, A.D, Humblet, C, Hupe, D.J, Blundell, T.L.
Deposit date:1999-06-11
Release date:1999-11-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structure of gelatinase A catalytic domain complexed with a hydroxamate inhibitor
Croatica Chemica Acta, 72, 1999
1QW7
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BU of 1qw7 by Molmil
Structure of an Engineered Organophosphorous Hydrolase with Increased Activity Toward Hydrolysis of Phosphothiolate Bonds
Descriptor: COBALT (II) ION, DIETHYL 4-METHYLBENZYLPHOSPHONATE, Parathion hydrolase, ...
Authors:Mesecar, A.D, Grimsley, J.K, Holton, T, Wild, J.R.
Deposit date:2003-09-01
Release date:2004-11-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site.
Arch.Biochem.Biophys., 442, 2005
1QSR
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BU of 1qsr by Molmil
CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND ACETYL-COENZYME A
Descriptor: ACETYL COENZYME *A, TGCN5 HISTONE ACETYL TRANSFERASE
Authors:Rojas, J.R, Trievel, R.C, Zhou, J, Mo, Y, Li, X, Berger, S.L, David Allis, C, Marmorstein, R.
Deposit date:1999-06-23
Release date:1999-09-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide.
Nature, 401, 1999
1QO6
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Solution structure of a pair of modules from the gelatin-binding domain of fibronectin
Descriptor: FIBRONECTIN
Authors:Bocquier, A.A, Potts, J.R, Pickford, A.R, Campbell, I.D.
Deposit date:1999-11-04
Release date:2000-01-11
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Solution Structure of a Pair of Modules from the Gelatin-Binding Domain of Fibronectin
Structure, 7, 1999
1QS0
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BU of 1qs0 by Molmil
Crystal Structure of Pseudomonas Putida 2-oxoisovalerate Dehydrogenase (Branched-Chain Alpha-Keto Acid Dehydrogenase, E1B)
Descriptor: 2-OXO-4-METHYLPENTANOIC ACID, 2-OXOISOVALERATE DEHYDROGENASE ALPHA-SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA-SUBUNIT, ...
Authors:Aevarsson, A, Seger, K, Turley, S, Sokatch, J.R, Hol, W.G.J.
Deposit date:1999-06-24
Release date:1999-08-18
Last modified:2021-08-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes.
Nat.Struct.Biol., 6, 1999
1QST
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BU of 1qst by Molmil
CRYSTAL STRUCTURE OF TETRAHYMENA GCN5
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, TGCN5 HISTONE ACETYL TRANSFERASE
Authors:Rojas, J.R, Trievel, R.C, Zhou, J, Mo, Y, Li, X, Berger, S.L, David Allis, C, Marmorstein, R.
Deposit date:1999-06-23
Release date:1999-09-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide.
Nature, 401, 1999
5JJW
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BU of 5jjw by Molmil
Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
Descriptor: 1,2-ETHANEDIOL, Squamous cell carcinoma antigen recognized by T-cells 3, UNKNOWN ATOM OR ION, ...
Authors:Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
to be published
5J3U
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BU of 5j3u by Molmil
Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Protein Kinase A
Authors:El Bakkouri, M, Walker, J.R, Tempel, W, Loppnau, P, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lin, L, Structural Genomics Consortium (SGC)
Deposit date:2016-03-31
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP
To Be Published
5J7D
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BU of 5j7d by Molmil
Computationally Designed Thioredoxin dF106
Descriptor: COPPER (II) ION, Designed Thioredoxin dF106
Authors:Horowitz, S, Johansen, N, Olsen, J.G, Winther, J.R.
Deposit date:2016-04-06
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone Template.
J.Mol.Biol., 428, 2016
5IUT
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BU of 5iut by Molmil
STRUCTURE OF P450 2B4 F202W MUTANT
Descriptor: 3,6,9,12,15,18-hexaoxahexacosan-1-ol, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE
Authors:Jang, H.-H, Halpert, J.R, Shah, M.B.
Deposit date:2016-03-18
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.
Biophys.Chem., 216, 2016
5J77
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BU of 5j77 by Molmil
Mutant glyceraldehyde dehydrogenase (F34M+S405N) from Thermoplasma acidophilum
Descriptor: D-glyceraldehyde dehydrogenase (NADP(+))
Authors:Iermak, I, Mesters, J.R, Kuta Smatanova, I.
Deposit date:2016-04-06
Release date:2017-05-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of wild-type glyceraldehyde dehydrogenase from Thermoplasma acidophilum in complex with NADP
To Be Published
5JMS
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BU of 5jms by Molmil
Crystal structure of TgCDPK1 bound to CGP060476
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Calmodulin-domain protein kinase 1, ...
Authors:El Bakkouri, M, Walker, J.R, Loppnau, P, Graslund, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Hui, R, Lovato, D.V, Structural Genomics Consortium (SGC)
Deposit date:2016-04-29
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of TgCDPK1bount to CGP060476
To Be Published
5JO5
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BU of 5jo5 by Molmil
Crystal structure of 10E8 gHV-gLV antigen-binding fragment.
Descriptor: 10E8 gHV, 10E8 gLV
Authors:Joyce, M.G, Mascola, J.R, Kwong, P.D.
Deposit date:2016-05-02
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.
Plos One, 11, 2016
1GU1
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BU of 1gu1 by Molmil
Crystal structure of type II dehydroquinase from Streptomyces coelicolor complexed with 2,3-anhydro-quinic acid
Descriptor: 2,3 -ANHYDRO-QUINIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-DEHYDROQUINATE DEHYDRATASE, ...
Authors:Roszak, A.W, Robinson, D.A, Krell, T, Hunter, I.S, Coggins, J.R, Lapthorn, A.J.
Deposit date:2002-01-22
Release date:2002-04-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure and Mechanism of the Type II Dehydroquinase from Streptomyces Coelicolor
Structure, 10, 2002
1H6R
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BU of 1h6r by Molmil
The oxidized state of a redox sensitive variant of green fluorescent protein
Descriptor: CHLORIDE ION, GREEN FLUORESCENT PROTEIN
Authors:Ostergaard, H, Henriksen, A, Hansen, F.G, Winther, J.R.
Deposit date:2001-06-22
Release date:2001-11-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Shedding Light on Disulfide Bond Formation: Engineering a Redox Switch in Green Fluorescent Protein
Embo J., 20, 2001
1HGX
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BU of 1hgx by Molmil
HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE (HGXPRTASE)
Descriptor: GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE, SULFATE ION
Authors:Somoza, J.R, Wang, C.C, Fletterick, R.J.
Deposit date:1996-03-12
Release date:1996-08-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.
Biochemistry, 35, 1996
1H3I
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BU of 1h3i by Molmil
Crystal structure of the Histone Methyltransferase SET7/9
Descriptor: HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE, MAGNESIUM ION
Authors:Wilson, J.R, Jing, C, Walker, P.A, Martin, S.R, Howell, S.A, Blackburn, G.M, Gamblin, S.J, Xiao, B.
Deposit date:2002-09-04
Release date:2002-11-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9
Cell(Cambridge,Mass.), 111, 2002
1GU0
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CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINASE FROM STREPTOMYCES COELICOLOR
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-DEHYDROQUINATE DEHYDRATASE
Authors:Roszak, A.W, Krell, T, Robinson, D, Hunter, I.S, Coggins, J.R, Lapthorn, A.J.
Deposit date:2002-01-22
Release date:2002-04-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure and Mechanism of the Type II Dehydroquinase from Streptomyces Coelicolor
Structure, 10, 2002
1H3D
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BU of 1h3d by Molmil
STRUCTURE OF THE E.COLI ATP-PHOSPHORIBOSYLTRANSFERASE
Descriptor: ADENOSINE MONOPHOSPHATE, ATP-PHOSPHORIBOSYLTRANSFERASE, L(+)-TARTARIC ACID
Authors:Lohkamp, B, McDermott, G, Coggins, J.R, Lapthorn, A.J.
Deposit date:2002-08-27
Release date:2003-10-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of Escherichia Coli ATP-Phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition
J.Mol.Biol., 336, 2004
7B5N
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BU of 7b5n by Molmil
Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-UBE2L3~Ub~ARIH1.
Descriptor: 5-azanylpentan-2-one, Cullin-1, E3 ubiquitin-protein ligase ARIH1, ...
Authors:Horn-Ghetko, D, Prabu, J.R, Schulman, B.A.
Deposit date:2020-12-05
Release date:2021-02-10
Last modified:2021-03-10
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
7B5R
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Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27
Descriptor: Cullin-1, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Horn-Ghetko, D, Prabu, J.R, Schulman, B.A.
Deposit date:2020-12-07
Release date:2021-02-10
Last modified:2021-03-10
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021

223532

數據於2024-08-07公開中

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