1QW7
Structure of an Engineered Organophosphorous Hydrolase with Increased Activity Toward Hydrolysis of Phosphothiolate Bonds
Summary for 1QW7
Entry DOI | 10.2210/pdb1qw7/pdb |
Related | 1DPM |
Descriptor | Parathion hydrolase, COBALT (II) ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | organophosphorous hydrolase, phosphotriesterase, vx, rvx, 4-methylbenzylphosphonate, mutant, hydrolase |
Biological source | Brevundimonas diminuta |
Cellular location | Cell membrane; Peripheral membrane protein: P0A434 |
Total number of polymer chains | 2 |
Total formula weight | 73555.11 |
Authors | Mesecar, A.D.,Grimsley, J.K.,Holton, T.,Wild, J.R. (deposition date: 2003-09-01, release date: 2004-11-30, Last modification date: 2023-11-15) |
Primary citation | Grimsley, J.K.,Calamini, B.,Wild, J.R.,Mesecar, A.D. Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site. Arch.Biochem.Biophys., 442:169-179, 2005 Cited by PubMed: 16188223DOI: 10.1016/j.abb.2005.08.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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