7SV8
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7SUW
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7SV1
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7SUY
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8SUV
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![BU of 8suv by Molmil](/molmil-images/mine/8suv) | CHIP-TPR in complex with the C-terminus of CHIC2 | Descriptor: | Cysteine-rich hydrophobic domain-containing protein 2, E3 ubiquitin-protein ligase CHIP, SULFATE ION | Authors: | Cupo, A.R, McDermott, L.E, DeSilva, A.R, Callahan, M, Nix, J.C, Gestwicki, J.E, Page, R.C. | Deposit date: | 2023-05-13 | Release date: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP Biorxiv, 2023
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1SM3
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![BU of 1sm3 by Molmil](/molmil-images/mine/1sm3) | CRYSTAL STRUCTURE OF THE TUMOR SPECIFIC ANTIBODY SM3 COMPLEX WITH ITS PEPTIDE EPITOPE | Descriptor: | CADMIUM ION, CHLORIDE ION, PEPTIDE EPITOPE, ... | Authors: | Dokurno, P, Bates, P.A, Band, H.A, Stewart, L.M.D, Lally, J.M, Burchell, J.M, Taylor-Papadimitriou, J, Sternberg, M.J.E, Snary, D, Freemont, P.S. | Deposit date: | 1997-12-23 | Release date: | 1999-03-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition. J.Mol.Biol., 284, 1998
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5TDQ
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![BU of 5tdq by Molmil](/molmil-images/mine/5tdq) | Crystal Structure of the GOLD domain of ACBD3 | Descriptor: | Golgi resident protein GCP60 | Authors: | McPhail, J.A, Burke, J.E. | Deposit date: | 2016-09-19 | Release date: | 2016-11-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase III beta , PI4KB, through ACBD3. Structure, 25, 2017
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6ASP
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![BU of 6asp by Molmil](/molmil-images/mine/6asp) | Structure of Grp94 with methyl 3-chloro-2-(2-(1-(2-ethoxybenzyl)-1 H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, a Grp94-selective inhibitor and promising therapeutic lead for treating myocilin-associated glaucoma | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Endoplasmin, GLYCEROL, ... | Authors: | Huard, D.J.E, Lieberman, R.L. | Deposit date: | 2017-08-25 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.696 Å) | Cite: | Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma. ACS Chem. Biol., 13, 2018
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3FI2
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![BU of 3fi2 by Molmil](/molmil-images/mine/3fi2) | Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451 | Descriptor: | 1,2-ETHANEDIOL, 3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}-N-(3,4,5-trimethoxyphenyl)benzamide, Mitogen-activated protein kinase 10 | Authors: | Habel, J.E. | Deposit date: | 2008-12-10 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J.Biol.Chem., 284, 2009
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3FI3
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![BU of 3fi3 by Molmil](/molmil-images/mine/3fi3) | Crystal structure of JNK3 with indazole inhibitor, SR-3737 | Descriptor: | 1,2-ETHANEDIOL, 3-{5-[(2-fluorophenyl)amino]-1H-indazol-1-yl}-N-(3,4,5-trimethoxyphenyl)benzamide, Mitogen-activated protein kinase 10 | Authors: | Habel, J.E, Duckett, D, LoGrasso, P. | Deposit date: | 2008-12-10 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J.Biol.Chem., 284, 2009
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7FBP
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![BU of 7fbp by Molmil](/molmil-images/mine/7fbp) | FXIIa-cMCoFx1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIIa light chain, cMCoFx1 | Authors: | Sengoku, T, Liu, W, de Veer, S.J, Huang, Y.H, Okada, C, Zdenek, C.N, Fry, B.G, Swedberg, J.E, Passioura, T, Craik, D.J, Suga, H, Ogata, K. | Deposit date: | 2021-07-12 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold. J.Am.Chem.Soc., 143, 2021
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5TOG
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![BU of 5tog by Molmil](/molmil-images/mine/5tog) | Room temperature structure of ubiquitin variant u7ub25.2540 | Descriptor: | Polyubiquitin-B, SULFATE ION | Authors: | Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S. | Deposit date: | 2016-10-17 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin. Structure, 25, 2017
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6AOM
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![BU of 6aom by Molmil](/molmil-images/mine/6aom) | Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 2-[2-(2-benzylphenyl)ethyl]-3-chloro-4,6-dihydroxybenzoate | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, DI(HYDROXYETHYL)ETHER, Endoplasmin, ... | Authors: | Lieberman, R.L, Huard, D.J.E. | Deposit date: | 2017-08-16 | Release date: | 2017-10-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer. Chemistry, 23, 2017
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8T3J
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![BU of 8t3j by Molmil](/molmil-images/mine/8t3j) | Crystal structure of native exfoliative toxin C (ExhC) from Mammaliicoccus sciuri | Descriptor: | Exfoliative toxin C | Authors: | Calil, F.A, Gismene, C, Hernandez Gonzalez, J.E, Ziem Nascimento, A.F, Santisteban, A.R.N, Arni, R.K, Barros Mariutti, R. | Deposit date: | 2023-06-07 | Release date: | 2023-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | Necrotic activity of ExhC from Mammaliicoccus sciuri is mediated by specific amino acid residues. Int.J.Biol.Macromol., 254, 2024
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8T3I
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![BU of 8t3i by Molmil](/molmil-images/mine/8t3i) | Crystal structure of mutant exfoliative toxin C (ExhC) from Mammaliicoccus sciuri | Descriptor: | Exfoliative toxin C | Authors: | Gismene, C, Calil, F.A, Hernandez Gonzalez, J.E, Ziem Nascimento, A.F, Santisteban, A.R.N, Arni, R.K, Barros Mariutti, R. | Deposit date: | 2023-06-07 | Release date: | 2023-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Necrotic activity of ExhC from Mammaliicoccus sciuri is mediated by specific amino acid residues. Int.J.Biol.Macromol., 254, 2024
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2MPR
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![BU of 2mpr by Molmil](/molmil-images/mine/2mpr) | MALTOPORIN FROM SALMONELLA TYPHIMURIUM | Descriptor: | CALCIUM ION, MALTOPORIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Meyer, J.E.W, Schulz, G.E. | Deposit date: | 1997-02-07 | Release date: | 1997-04-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of maltoporin from Salmonella typhimurium ligated with a nitrophenyl-maltotrioside. J.Mol.Biol., 266, 1997
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6ASQ
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![BU of 6asq by Molmil](/molmil-images/mine/6asq) | Structure of Grp94 bound to methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, a pan-Hsp90 inhibitor | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, Endoplasmin, ... | Authors: | Huard, D.J.E, Lieberman, R.L. | Deposit date: | 2017-08-25 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma. ACS Chem. Biol., 13, 2018
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5T96
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![BU of 5t96 by Molmil](/molmil-images/mine/5t96) | Crystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complex | Descriptor: | 4-O-acetyl-5-acetamido-3,5-dideoxy-L-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, FORMIC ACID, GLYCEROL, ... | Authors: | Cook, J.D, Sultana, A, Lee, J.E. | Deposit date: | 2016-09-09 | Release date: | 2017-03-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1C3I
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![BU of 1c3i by Molmil](/molmil-images/mine/1c3i) | HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 | Descriptor: | 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER, CALCIUM ION, STROMELYSIN-1, ... | Authors: | Steele, D.L, Kammlott, R.U, Crowther, R.L, Birktoft, J.J, Dunten, P, Engler, J.E. | Deposit date: | 1999-07-27 | Release date: | 2000-07-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1. Protein Eng., 13, 2000
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1RF8
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![BU of 1rf8 by Molmil](/molmil-images/mine/1rf8) | Solution structure of the yeast translation initiation factor eIF4E in complex with m7GDP and eIF4GI residues 393 to 490 | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic initiation factor 4F subunit p150, Eukaryotic translation initiation factor 4E, ... | Authors: | Gross, J.D, Moerke, N.J, von der Haar, T, Lugovskoy, A.A, Sachs, A.B, McCarthy, J.E.G, Wagner, G. | Deposit date: | 2003-11-07 | Release date: | 2003-12-23 | Last modified: | 2024-03-06 | Method: | SOLUTION NMR | Cite: | Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell(Cambridge,Mass.), 115, 2003
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5TV6
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![BU of 5tv6 by Molmil](/molmil-images/mine/5tv6) | A. aeolicus BioW with pimelate | Descriptor: | 6-carboxyhexanoate--CoA ligase, PIMELIC ACID | Authors: | Estrada, P, Manandhar, M, Dong, S.-H, Deveryshetty, J, Agarwal, V, Cronan, J.E, Nair, S.K. | Deposit date: | 2016-11-08 | Release date: | 2016-12-07 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.456 Å) | Cite: | The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes. Nat. Chem. Biol., 13, 2017
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5TV5
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![BU of 5tv5 by Molmil](/molmil-images/mine/5tv5) | BioW from Aquifex aeoulicus | Descriptor: | 6-carboxyhexanoate--CoA ligase | Authors: | Estrada, P, Manandhar, M, Dong, S.-H, Deveryshetty, J, Agarwal, V, Cronan, J.E, Nair, S.K. | Deposit date: | 2016-11-08 | Release date: | 2016-12-07 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes. Nat. Chem. Biol., 13, 2017
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8TOA
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![BU of 8toa by Molmil](/molmil-images/mine/8toa) | CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H7.HK2 Neutralizing Antibody Heavy Chain, H7.HK2 Neutralizing Antibody Light Chain, ... | Authors: | Morano, N.C, Becker, J.E, Wu, X, Shapiro, L. | Deposit date: | 2023-08-03 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK1 To Be Published
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2OC3
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![BU of 2oc3 by Molmil](/molmil-images/mine/2oc3) | Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 18 | Descriptor: | Tyrosine-protein phosphatase non-receptor type 18 | Authors: | Ugochukwu, E, Barr, A, Alfano, I, Gorrec, F, Umeano, C, Savitsky, P, Sobott, F, Eswaran, J, Papagrigoriou, E, Debreczeni, J.E, Turnbull, A, Bunkoczi, G, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-20 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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6BP2
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![BU of 6bp2 by Molmil](/molmil-images/mine/6bp2) | Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ... | Authors: | King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O. | Deposit date: | 2017-11-21 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.172 Å) | Cite: | The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe, 23, 2018
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