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PDB: 6634 results

5BT4
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Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe
Descriptor: 1,2-ETHANEDIOL, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, Bromodomain-containing protein 4
Authors:Tallant, C, Hay, D, Krojer, T, Nunez-Alonso, G, Picaud, S, Newman, J.A, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2015-06-02
Release date:2015-07-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of BRD4 first bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
5AMX
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BU of 5amx by Molmil
Crystal Structure of Proteinase K processed with the CrystalDirect automated mounting and cryo-cooling technology
Descriptor: PROTEINASE K, SULFATE ION
Authors:Zander, U, Hoffmann, G, Cornaciu, I, Cipriani, F, Marquez, J.A.
Deposit date:2015-09-02
Release date:2016-04-13
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation.
Acta Crystallogr.,Sect.D, 72, 2016
7JVG
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BU of 7jvg by Molmil
Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachidonoylglycerol
Descriptor: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, Retinol-binding protein 2
Authors:Silvaroli, J.A, Golczak, M.
Deposit date:2020-08-21
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands.
J.Lipid Res., 62, 2021
7JVY
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Cellular retinol-binding protein 2 (CRBP2) in complex with 2-arachidonylglyceryl ether
Descriptor: 2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-yl]oxy}propane-1,3-diol, Retinol-binding protein 2
Authors:Silvaroli, J.A, Banarjee, S, Golczak, M.
Deposit date:2020-08-24
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands.
J.Lipid Res., 62, 2021
7JZ5
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BU of 7jz5 by Molmil
Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachodonoyl-1-thio-glycerol
Descriptor: Retinol-binding protein 2, S-[(2R)-2,3-dihydroxypropyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate
Authors:Silvaroli, J.A, Banarjee, S, Golczak, M.
Deposit date:2020-09-01
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.567 Å)
Cite:Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands.
J.Lipid Res., 62, 2021
3ENE
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BU of 3ene by Molmil
Complex of PI3K gamma with an inhibitor
Descriptor: 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Apsel, B, Blair, J.A, Gonzalez, B.Z, Nazif, T.M, Feldman, M.E, Williams, R.L, Shokat, K.M, Knight, Z.A.
Deposit date:2008-09-25
Release date:2008-10-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Nat.Chem.Biol., 4, 2008
1T6Q
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Nickel Superoxide Dismutase (NiSOD) CN-treated Apo Structure
Descriptor: Superoxide dismutase [Ni]
Authors:Barondeau, D.P, Kassmann, C.J, Bruns, C.K, Tainer, J.A, Getzoff, E.D.
Deposit date:2004-05-07
Release date:2004-07-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Nickel superoxide dismutase structure and mechanism.
Biochemistry, 43, 2004
1TLL
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BU of 1tll by Molmil
CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.
Descriptor: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Garcin, E.D, Bruns, C.M, Lloyd, S.J, Hosfield, D.J, Tiso, M, Gachhui, R, Stuehr, D.J, Tainer, J.A, Getzoff, E.D.
Deposit date:2004-06-09
Release date:2004-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase
J.Biol.Chem., 279, 2004
1SRR
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BU of 1srr by Molmil
CRYSTAL STRUCTURE OF A PHOSPHATASE RESISTANT MUTANT OF SPORULATION RESPONSE REGULATOR SPO0F FROM BACILLUS SUBTILIS
Descriptor: CALCIUM ION, SPORULATION RESPONSE REGULATORY PROTEIN
Authors:Madhusudan, Whiteley, J.M, Hoch, J.A, Zapf, J, Xuong, N.H, Varughese, K.I.
Deposit date:1996-04-10
Release date:1997-04-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a phosphatase-resistant mutant of sporulation response regulator Spo0F from Bacillus subtilis.
Structure, 4, 1996
3E7G
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BU of 3e7g by Molmil
Structure of human INOSOX with inhibitor AR-C95791
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE, Nitric oxide synthase, ...
Authors:Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D.
Deposit date:2008-08-18
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008
3V90
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BU of 3v90 by Molmil
Structure of T82M glycogenin mutant truncated at residue 270
Descriptor: CHLORIDE ION, GLYCEROL, Glycogenin-1
Authors:Carrizo, M.E, Romero, J.M, Issoglio, F.M, Curtino, J.A.
Deposit date:2011-12-23
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation.
Febs Lett., 586, 2012
5BT5
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BU of 5bt5 by Molmil
Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe
Descriptor: 1,2-ETHANEDIOL, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, Bromodomain-containing protein 2
Authors:Tallant, C, Hay, D, Krojer, T, Nunez-Alonso, G, Picaud, S, Newman, J.A, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2015-06-02
Release date:2015-07-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of BRD2 second bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
1SZK
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BU of 1szk by Molmil
The structure of gamma-aminobutyrate aminotransferase mutant: E211S
Descriptor: 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminobutyrate aminotransferase, ...
Authors:Liu, W, Peterson, P.E, Langston, J.A, Jin, X, Fisher, A.J, Toney, M.D.
Deposit date:2004-04-05
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase.
Biochemistry, 44, 2005
1T0K
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BU of 1t0k by Molmil
Joint X-ray and NMR Refinement of Yeast L30e-mRNA complex
Descriptor: 5'-R(*G*GP*AP*CP*GP*CP*AP*GP*AP*GP*AP*UP*GP*GP*UP*C)-3', 5'-R(*GP*AP*CP*CP*GP*GP*AP*GP*UP*GP*UP*CP*C)-3', 60S ribosomal protein L30, ...
Authors:Chao, J.A, Williamson, J.R.
Deposit date:2004-04-09
Release date:2004-07-20
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Joint X-Ray and NMR Refinement of the Yeast L30e-mRNA Complex
Structure, 12, 2004
5BOP
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BU of 5bop by Molmil
Crystal structure of the artificial nanobody octarellinV.1 complex
Descriptor: Nanobody, Octarellin V.1
Authors:Figueroa, M, Sleutel, M, Pardon, E, Steyaert, J, Martial, J.A, van de Weerdt, C.
Deposit date:2015-05-27
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
3EVJ
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BU of 3evj by Molmil
Intermediate structure of antithrombin bound to the natural pentasaccharide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ...
Authors:Huntington, J.A, Belzar, K.J.
Deposit date:2008-10-13
Release date:2008-10-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
J. Mol. Biol., 386, 2009
3EN4
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BU of 3en4 by Molmil
Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor
Descriptor: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:Blair, J.A, Apsel, B, Knight, Z.A, Shokat, K.M.
Deposit date:2008-09-25
Release date:2008-10-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Nat.Chem.Biol., 4, 2008
1T6I
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BU of 1t6i by Molmil
Nickel Superoxide Dismutase (NiSOD) Apo Structure
Descriptor: Superoxide dismutase [Ni]
Authors:Barondeau, D.P, Kassmann, C.J, Bruns, C.K, Tainer, J.A, Getzoff, E.D.
Deposit date:2004-05-06
Release date:2004-07-13
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Nickel superoxide dismutase structure and mechanism.
Biochemistry, 43, 2004
1T9C
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BU of 1t9c by Molmil
Crystal Structure Of Yeast Acetohydroxyacid Synthase In Complex With A Sulfonylurea Herbicide, Sulfometuron methyl
Descriptor: Acetolactate synthase, mitochondrial, ETHYL DIHYDROGEN DIPHOSPHATE, ...
Authors:McCourt, J.A, Pang, S.S, Guddat, L.W, Duggleby, R.G.
Deposit date:2004-05-16
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase.
Biochemistry, 44, 2005
1TA6
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BU of 1ta6 by Molmil
Crystal structure of thrombin in complex with compound 14b
Descriptor: 1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE, Hirudin, thrombin
Authors:Tucker, T.J, Brady, S.F, Lumma, W.C, Lewis, S.D, Gardel, S.J, Naylor-Olsen, A.M, Yan, Y, Sisko, J.T, Stauffer, K.J, Lucas, B.Y, Lynch, J.J, Cook, J.J, Stranieri, M.T, Holahan, M.A, Lyle, E.A, Baskin, E.P, Chen, I.-W, Dancheck, K.B, Krueger, J.A, Cooper, C.M, Vacca, J.P.
Deposit date:2004-05-19
Release date:2004-06-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position
J.Med.Chem., 41, 1998
7JRR
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BU of 7jrr by Molmil
Crystal structures of artificially designed homomeric RNA nanoarchitectures
Descriptor: MAGNESIUM ION, MANGANESE (II) ION, RNA (50-MER)
Authors:Liu, D, Shao, Y, Piccirilli, J.A, Weizmann, Y.
Deposit date:2020-08-12
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution.
Sci Adv, 7, 2021
7JRT
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BU of 7jrt by Molmil
Crystal structures of artificially designed homomeric RNA nanoarchitectures
Descriptor: RNA nano bracelet
Authors:Liu, D, Shao, Y, Piccirilli, J.A, Weizmann, Y.
Deposit date:2020-08-12
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution.
Sci Adv, 7, 2021
3EY0
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BU of 3ey0 by Molmil
A new form of DNA-drug interaction in the minor groove of a coiled coil
Descriptor: 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, 5'-D(*DAP*DTP*DAP*DTP*DAP*DTP*DAP*DTP*DAP*DT)-3', MAGNESIUM ION
Authors:Pous, J, Moreno, T, Subirana, J.A, Campos, J.L.
Deposit date:2008-10-17
Release date:2009-10-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Coiled-coil conformation of a pentamidine-DNA complex
Acta Crystallogr.,Sect.D, 66, 2010
3V8Y
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Structure of apo-glycogenin truncated at residue 270
Descriptor: CHLORIDE ION, GLYCEROL, Glycogenin-1
Authors:Carrizo, M.E, Romero, J.M, Issoglio, F.M, Curtino, J.A.
Deposit date:2011-12-23
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation.
Febs Lett., 586, 2012
3V91
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Structure of T82M glycogenin mutant truncated at residue 270 complexed with UDP-glucose
Descriptor: CHLORIDE ION, GLYCEROL, Glycogenin-1, ...
Authors:Carrizo, M.E, Romero, J.M, Issoglio, F.M, Curtino, J.A.
Deposit date:2011-12-23
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation.
Febs Lett., 586, 2012

223790

數據於2024-08-14公開中

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