6PV7
 
 | | Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine | | Descriptor: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Gharpure, A, Teng, J, Zhuang, Y, Noviello, C.M, Walsh, R.M, Cabuco, R, Howard, R.J, Zaveri, N.T, Lindahl, E, Hibbs, R.E. | | Deposit date: | 2019-07-19 | | Release date: | 2019-09-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor.
Neuron, 104, 2019
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6SY4
 | | TetR in complex with the TetR-binding RNA-aptamer K1 | | Descriptor: | TetR-binding aptamer K1 (43-MER), Tetracycline repressor protein class B from transposon Tn10 | | Authors: | Grau, F.C, Muller, Y.A, Suess, B, Groher, F, Jaeger, J. | | Deposit date: | 2019-09-27 | | Release date: | 2020-02-05 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.695 Å) | | Cite: | The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex.
Nucleic Acids Res., 48, 2020
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8VJ4
 | | X-ray Counterpart to the Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD | | Descriptor: | HYDROGEN PEROXIDE, MANGANESE (II) ION, Superoxide dismutase [Mn], ... | | Authors: | Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
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8VHW
 | | Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD | | Descriptor: | HYDROGEN PEROXIDE, MANGANESE (II) ION, Superoxide dismutase [Mn], ... | | Authors: | Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Coates, L, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O. | | Deposit date: | 2024-01-02 | | Release date: | 2024-07-31 | | Method: | NEUTRON DIFFRACTION (2.3 Å) | | Cite: | Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
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3URI
 | | Endothiapepsin-DB5 complex. | | Descriptor: | DB5 peptide, Endothiapepsin | | Authors: | Bailey, D, Sanz-Aparicio, J, Albert, A, Cooper, J.B. | | Deposit date: | 2011-11-22 | | Release date: | 2012-04-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012
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8VHY
 | | Neutron Structure of Reduced Trp161Phe MnSOD | | Descriptor: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | | Authors: | Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Coates, L, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O. | | Deposit date: | 2024-01-02 | | Release date: | 2024-07-31 | | Method: | NEUTRON DIFFRACTION (2.3 Å) | | Cite: | Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
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8V3M
 | | CCP5 apo structure | | Descriptor: | Cytosolic carboxypeptidase-like protein 5, D-MALATE, IMIDAZOLE, ... | | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | | Deposit date: | 2023-11-28 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.
Nature, 631, 2024
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4YCW
 | | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | | Descriptor: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... | | Authors: | Fang, P, Wang, J, Guo, M. | | Deposit date: | 2015-02-20 | | Release date: | 2015-06-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor
Chem.Biol., 22, 2015
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8VD1
 | | Crystal Structure of KAI2 from Oryza sativa with MPD | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Probable esterase D14L | | Authors: | Gilio, A.K, Shabek, N, Guercio, A.M, Pawlak, J. | | Deposit date: | 2023-12-14 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction.
J.Biol.Chem., 2024
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8VJ5
 | | Peroxide-Soaked MnSOD | | Descriptor: | HYDROGEN PEROXIDE, MANGANESE (II) ION, PHOSPHATE ION, ... | | Authors: | Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
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6PT2
 | | Crystal structure of the active delta opioid receptor in complex with the peptide agonist KGCHM07 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Delta opioid receptor, ... | | Authors: | Claff, T, Yu, J, Blais, V, Patel, N, Martin, C, Wu, L, Han, G.W, Holleran, B.J, Van der Poorten, O, Hanson, M.A, Sarret, P, Gendron, L, Cherezov, V, Katritch, V, Ballet, S, Liu, Z, Muller, C.E, Stevens, R.C. | | Deposit date: | 2019-07-14 | | Release date: | 2019-12-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists.
Sci Adv, 5, 2019
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6PSW
 | | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPo) with TraR and rpsT P2 promoter | | Descriptor: | CHAPSO, DNA (85-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | | Deposit date: | 2019-07-13 | | Release date: | 2020-03-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Stepwise Promoter Melting by Bacterial RNA Polymerase.
Mol.Cell, 78, 2020
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8VJ0
 | | Neutron Structure of Oxidized Trp161Phe MnSOD | | Descriptor: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | | Authors: | Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-31 | | Method: | NEUTRON DIFFRACTION (2.3 Å) | | Cite: | Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
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8VD7
 | | MicroED structure of SARS-CoV-2 main protease (MPro/3CLPro) with missing cone eliminated by suspended drop | | Descriptor: | 3C-like proteinase nsp5, CHLORIDE ION | | Authors: | Bu, G, Gillman, C, Danelius, E, Hattne, J, Nannenga, B.L, Gonen, T. | | Deposit date: | 2023-12-14 | | Release date: | 2024-07-17 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.15 Å) | | Cite: | Eliminating the missing cone challenge through innovative approaches.
J Struct Biol X, 9, 2024
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8V3O
 | | CCP5 in complex with Glu-P-peptide 1 transition state analog | | Descriptor: | Cytosolic carboxypeptidase-like protein 5, D-MALATE, POTASSIUM ION, ... | | Authors: | Chen, J, Zehr, E.A, Gruschus, J.M, Szyk, A, Liu, Y, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | | Deposit date: | 2023-11-28 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.
Nature, 631, 2024
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6PU4
 | | MicroED structure of proteinase K recorded on Falcon III | | Descriptor: | CALCIUM ION, Proteinase K | | Authors: | Hattne, J, Martynowycz, M.W, Penzcek, P.A, Gonen, T. | | Deposit date: | 2019-07-17 | | Release date: | 2019-08-28 | | Last modified: | 2023-10-11 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | | Cite: | MicroED with the Falcon III direct electron detector.
Iucrj, 6, 2019
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2BMV
 | | Apoflavodoxin from Helicobacter pylori | | Descriptor: | BENZAMIDINE, CHLORIDE ION, FLAVODOXIN | | Authors: | Martinez-Julvez, M, Hermoso, J.A, Sancho, J, Perez-Dorado, I, Cremades, N, Bueno, M. | | Deposit date: | 2005-03-16 | | Release date: | 2006-06-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Common Conformational Changes in Flavodoxins Induced by Fmn and Anion Binding: The Structure of Helicobacter Pylori Apoflavodoxin.
Proteins, 69, 2007
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8WHB
 | | Structure of nucleosome core particle of Arabidopsis thaliana | | Descriptor: | DNA (antisense strand), DNA (sense strand), Histone H2A.6, ... | | Authors: | Liu, Y, Zhang, Z, Du, J. | | Deposit date: | 2023-09-23 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation.
Nat.Plants, 10, 2024
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1JY8
 | | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) | | Descriptor: | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ... | | Authors: | Steinbacher, S, Kaiser, J, Wungsintaweekul, J, Hecht, S, Eisenreich, W, Gerhardt, S, Bacher, A, Rohdich, F. | | Deposit date: | 2001-09-11 | | Release date: | 2002-01-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.
J.Mol.Biol., 316, 2002
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6SP5
 | | Structure of hyperstable haloalkane dehalogenase variant DhaA115 | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Haloalkane dehalogenase, ... | | Authors: | Chmelova, K, Markova, K, Damborsky, J, Marek, M. | | Deposit date: | 2019-08-30 | | Release date: | 2020-11-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst.
Chem Sci, 11, 2020
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4PKX
 | | The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold | | Descriptor: | Protein C10C5.1, isoform i | | Authors: | Kamajaya, A, Kaiser, J, Lee, J, Reid, M, Rees, D.C. | | Deposit date: | 2014-05-15 | | Release date: | 2014-10-08 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct beta Sandwich Fold.
Structure, 22, 2014
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4YIK
 | | Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU | | Descriptor: | 1-{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-[(E)-2-phosphonoethenyl]pyrimidine-2,4(1H,3H)-dione, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'(3')-deoxyribonucleotidase, ... | | Authors: | Pachl, P, Rezacova, P, Brynda, J. | | Deposit date: | 2015-03-02 | | Release date: | 2015-09-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.483 Å) | | Cite: | Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor
Medchemcomm, 6, 2015
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8WD2
 | | The Crystal Structure of p53 from Biortus. | | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, PHOSPHATE ION, ... | | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Lu, Y. | | Deposit date: | 2023-09-14 | | Release date: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The Crystal Structure of p53 from Biortus.
To Be Published
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4YLW
 | | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound | | Descriptor: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Wu, D, Ouyang, P, Lu, W, Huang, J. | | Deposit date: | 2015-03-06 | | Release date: | 2016-03-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound
To Be Published
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4F7M
 | | Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PA (649-658) | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | | Authors: | Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, George, F.G. | | Deposit date: | 2012-05-16 | | Release date: | 2012-10-10 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals.
J.Virol., 86, 2012
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