3BHH
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![BU of 3bhh by Molmil](/molmil-images/mine/3bhh) | Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B) | 分子名称: | Calcium/calmodulin-dependent protein kinase type II beta chain, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile | 著者 | Filippakopoulos, P, Rellos, P, Niesen, F, Burgess, N, Bullock, A, Berridge, G, Pike, A.C.W, Ugochukwu, E, Pilka, E.S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-11-28 | 公開日 | 2007-12-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of Human Calcium/Calmodulin-Dependent Protein Kinase IIB Isoform 1 (CAMK2B). To be Published
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7RL5
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![BU of 7rl5 by Molmil](/molmil-images/mine/7rl5) | Yeast CTP Synthase (URA8) filament bound to CTP at low pH | 分子名称: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-23 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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6WZ6
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![BU of 6wz6 by Molmil](/molmil-images/mine/6wz6) | Complex of mutant (K173M) of Pseudomonas 7A Glutaminase-Asparaginase with L-Glu at pH 5. Covalent acyl-enzyme intermediate | 分子名称: | 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutaminase-asparaginase | 著者 | Strzelczyk, P, Zhang, D, Wlodawer, A, Lubkowski, J. | 登録日 | 2020-05-13 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Generalized enzymatic mechanism of catalysis by tetrameric L-asparaginases from mesophilic bacteria. Sci Rep, 10, 2020
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7RMO
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![BU of 7rmo by Molmil](/molmil-images/mine/7rmo) | Yeast CTP Synthase (Ura7) Bundle bound to Products at low pH | 分子名称: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-27 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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7RL0
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![BU of 7rl0 by Molmil](/molmil-images/mine/7rl0) | Yeast CTP Synthase (URA8) Filament bound to ATP/UTP at low pH | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, MAGNESIUM ION, ... | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-22 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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7RNL
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![BU of 7rnl by Molmil](/molmil-images/mine/7rnl) | Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates | 分子名称: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-29 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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2XKB
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6X0O
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![BU of 6x0o by Molmil](/molmil-images/mine/6x0o) | Single-Particle Cryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, CALCIUM ION, Integral membrane indolylacetylinositol arabinosyltransferase EmbB | 著者 | Tan, Y.Z, Rodrigues, J, Keener, J.E, Zheng, R.B, Brunton, R, Kloss, B, Giacometti, S.I, Rosario, A.L, Zhang, L, Niederweis, M, Clarke, O.B, Lowary, T.L, Marty, M.T, Archer, M, Potter, C.S, Carragher, B, Mancia, F. | 登録日 | 2020-05-17 | 公開日 | 2020-06-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis. Nat Commun, 11, 2020
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6Q8P
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![BU of 6q8p by Molmil](/molmil-images/mine/6q8p) | Structure of CLK1 with bound N-methyl-10-nitropyrido[3,4-g]quinazolin-2-amine | 分子名称: | Dual specificity protein kinase CLK1, POTASSIUM ION, ~{N}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine | 著者 | Joerger, A.C, Chatterjee, D, Schroeder, M, Tazarki, H, Zeinyeh, W, Esvan, Y.J, Khiari, J, Josselin, B, Baratte, B, Bach, S, Ruchaud, S, Anizon, F, Giraud, F, Moreau, P, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2018-12-15 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur J Med Chem, 166, 2019
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8RM5
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![BU of 8rm5 by Molmil](/molmil-images/mine/8rm5) | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'SS oligo, NHP2-like protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2024-01-05 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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6Q1R
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7WBJ
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![BU of 7wbj by Molmil](/molmil-images/mine/7wbj) | Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W. | 登録日 | 2021-12-16 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nat Commun, 13, 2022
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4NXE
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![BU of 4nxe by Molmil](/molmil-images/mine/4nxe) | Crystal structure of iLOV-I486(2LT) at pH 6.5 | 分子名称: | FLAVIN MONONUCLEOTIDE, Phototropin-2 | 著者 | Wang, J, Liu, X, Li, J. | 登録日 | 2013-12-09 | 公開日 | 2014-09-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | 主引用文献 | Significant expansion of fluorescent protein sensing ability through the genetic incorporation of superior photo-induced electron-transfer quenchers. J.Am.Chem.Soc., 136, 2014
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6X3Z
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![BU of 6x3z by Molmil](/molmil-images/mine/6x3z) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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7R81
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![BU of 7r81 by Molmil](/molmil-images/mine/7r81) | Structure of the translating Neurospora crassa ribosome arrested by cycloheximide | 分子名称: | 18S rRNA, 26S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | 著者 | Shen, L, Su, Z, Yang, K, Wu, C, Becker, T, Bell-Pedersen, D, Zhang, J, Sachs, M.S. | 登録日 | 2021-06-25 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structure of the translating Neurospora ribosome arrested by cycloheximide Proc.Natl.Acad.Sci.USA, 118, 2021
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8BNR
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![BU of 8bnr by Molmil](/molmil-images/mine/8bnr) | Escherichia coli anaerobic fatty acid beta oxidation trifunctional enzyme (anEcTFE) octameric complex | 分子名称: | 3-ketoacyl-CoA thiolase FadI, Fatty acid oxidation complex subunit alpha | 著者 | Sah-Teli, S.K, Pinkas, M, Novacek, J, Venkatesan, R. | 登録日 | 2022-11-14 | 公開日 | 2023-05-17 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (10.3 Å) | 主引用文献 | Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial beta-oxidation trifunctional enzymes. Structure, 31, 2023
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8SC9
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![BU of 8sc9 by Molmil](/molmil-images/mine/8sc9) | Structure of PPARG in complex with MTX-531 | 分子名称: | N-[(5P)-2-chloro-5-(4-{[(1R)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide, Peroxisome proliferator-activated receptor gamma, SULFATE ION, ... | 著者 | Whitehead, C.E, Leopold, J. | 登録日 | 2023-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.855 Å) | 主引用文献 | Structure of PPARG in complex with MTX-531 To Be Published
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8SC7
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5WYS
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![BU of 5wys by Molmil](/molmil-images/mine/5wys) | luciferase with inhibitor 3i | 分子名称: | 5-[(3R)-3-(4-boranylphenyl)-3-oxidanyl-propyl]-2-oxidanyl-benzoic acid, Luciferin 4-monooxygenase | 著者 | Gu, L, Su, J, Wang, F. | 登録日 | 2017-01-15 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.999 Å) | 主引用文献 | Inhibiting Firefly Bioluminescence by Chalcones Anal. Chem., 89, 2017
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7RLO
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![BU of 7rlo by Molmil](/molmil-images/mine/7rlo) | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs | 分子名称: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | 著者 | Wang, L, Schoof, M, Cogan, J, Lawrence, R, Boone, M, Wuerth, J, Frost, M, Walter, P. | 登録日 | 2021-07-26 | 公開日 | 2021-12-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12, 2021
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8RSA
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8B6I
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![BU of 8b6i by Molmil](/molmil-images/mine/8b6i) | KRasG12C ligand complex | 分子名称: | 1-[(4~{a}~{S})-7-chloranyl-8-(5-methyl-2~{H}-indazol-4-yl)-1,2,4,4~{a},5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Phillips, C, Breed, J. | 登録日 | 2022-09-27 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration. J.Med.Chem., 66, 2023
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6WEV
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![BU of 6wev by Molmil](/molmil-images/mine/6wev) | Crystal structures of human E-NPP 1: bound to N-{[1-(6,7-dimethoxy-5,8-dihydroquinazolin-4-yl)piperidin-4-yl]methyl}sulfuric diamide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Peat, T.S, Dennis, M, Newman, J. | 登録日 | 2020-04-03 | 公開日 | 2020-09-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of human ENPP1 in apo and bound forms. Acta Crystallogr D Struct Biol, 76, 2020
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2NSK
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8B6S
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![BU of 8b6s by Molmil](/molmil-images/mine/8b6s) | X-ray structure of the haloalkane dehalogenase HaloTag7 fusion to the green fluorescent protein GFP (ChemoG1) labeled with a chloroalkane tetramethylrhodamine fluorophore substrate | 分子名称: | CHLORIDE ION, GLYCEROL, Green fluorescent protein,Haloalkane dehalogenase, ... | 著者 | Tarnawski, M, Hellweg, L, Hiblot, J. | 登録日 | 2022-09-27 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A general method for the development of multicolor biosensors with large dynamic ranges. Nat.Chem.Biol., 19, 2023
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